Navigation Links
Physical reason for chromosome shape discovered
Date:1/14/2014

This work gives a solution to a fundamental question in structural biology: Why do metaphase chromosomes have their characteristic elongated cylindrical shape? The proposed solution is consistent with the structure of metaphase chromatin and with the nanomechanical properties of chromatin and chromosomes. It is a research at the interface between biology (higher order chromatin structure) and physical sciences (supramolecular structures and nanomaterials). This approach goes beyond the capabilities of current structural biology based on X-ray crystallography, because it allows the study of an enormous supramolecular assembly that cannot be crystallized. The work has been published in the Journal of the Royal Society Interface.

In the cell nucleus, genomic DNA molecules are associated with histone proteins and form long chromatin filaments containing many nucleosomes. Previous microscopy studies performed by researchers at the Chromatin Laboratory directed by professor Joan-Ramon Daban (Biosciences Unit of the Department of Biochemistry and Molecular Biology, UAB) showed that, during cell division, chromatin filaments are folded into multilayer planar structures. This discovery led to the thin-plate model in which it was proposed that condensed chromosomes are formed by many stacked layers of chromatin oriented perpendicular to the chromosome axis.

The measurements performed by professor Daban show that chromosomes of different animal and plant species exhibit great differences in size (which are dependent on the amount of DNA that they contain), but in all cases chromosomes are elongated cylinders that have relatively similar shape proportions (the length to diameter ratio is approximately 13). This study demonstrates that it is possible to explain this morphology by considering that chromosomes are self-organizing supramolecular structures formed by stacked layers of planar chromatin having different nucleosome-nucleosome interactio
'/>"/>

Contact: Joan-Ramon Daban
Joanramon.daban@uab.cat
34-935-811-616
Universitat Autonoma de Barcelona
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Increasing clarity for medics in suspected physical abuse cases
2. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
3. UTHealth study addresses barriers to physical activity counseling
4. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
5. Iron, vitamins could affect physical fitness in adolescents
6. Childrens physical activity levels are not enough to counteract sedentary lifestyles
7. Biophysical Society names 5 2013 award recipients
8. Biophysical Society names 2013 Distinguished Service, Emily M. Gray, and Founders awardees
9. New study finds milk-drinking kids reap physical benefits later in life
10. Dark Energy: Life beneath the seafloor discussed at upcoming American Geophysical Union conference
11. UT study: Students who are more physically fit perform better academically
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Physical reason for chromosome shape discovered
(Date:8/18/2015)... DUBLIN , Aug. 17, 2015 ... the addition of the "Global Biometric Authentication ... Application - Estimation & Forecast, 2015-2020" report ... biometric authentication and identification systems market is expected ... from 2015 to 2020 and generate over $25 ...
(Date:8/12/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... announced that four of its fingerprint ID products, ... been named FIDO Certified™ by the Fast IDentity ... Synaptics, Natural ID™ fingerprint solutions are fully compliant ... standard and are interoperable among other products and ...
(Date:8/6/2015)... TELTOW, Germany , August 6, 2015 ... SensoMotoric Instruments (SMI) shows the world,s first ... based on Epson,s Moverio BT-200 see-through head mounted ... this new solution, unprecedented quality and efficiency is brought ... context-sensitive displays. For the first time, professionals and researchers ...
Breaking Biology News(10 mins):Global Biometric Authentication & Identification Market 2015: Focus On Modality, Motility & Application - Estimation & Forecasts to 2020 for the $25 Billion Industry 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 2SMI Shows First Eye Tracking Upgrade for Augmented Reality Glasses 3
... access to information about biodiversity is of crucial importance ... climate change research and education. "Non-Commercial" restrictions on the ... addressing these problems, says a review paper published in ... Halting the loss of biodiversity demands that information ...
... University of Seville (Spain) have developed a technique based ... of beer. The content of iron, potassium, phosphates and ... and Portuguese beers have been detected with 99% accuracy ... from one another according to their country of origin ...
... from North Carolina State University, the University of Washington ... most diverse collections of prehistoric non-native animal remains in ... find contributes to our understanding of culture in the ... may have been more important than previously thought. ...
Cached Biology News:Creative Commons 'non-commercial' licenses impede the re-use of biodiversity information 2Where does my beer come from? 2Archaeologists find new evidence of animals being introduced to prehistoric Caribbean 2
(Date:8/28/2015)... ... ... the initial launch of FireflySci Inc. (FFS) in early 2015, the company continues to shake ... as the Fonz in a lab coat and Large Marge have been posted on the ... , FireflySci is proud to be the only cuvette manufacturer is the world that ...
(Date:8/27/2015)... (PRWEB) , ... August 27, 2015 , ... Capital ... solve complex business problems, is pleased to announce their ranking as one of the ... ranking of the fastest-growing private companies across the nation. , “It is truly an ...
(Date:8/27/2015)... 27, 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") ... Biohaven Pharmaceutical Holding Company Limited (Biohaven), announced today ... study of BHV-0223, a glutamate modulating agent. Biohaven ... and recently obtained clearance from the U.S. Food ... testing. Portage holds 54% equity interest in Biohaven, ...
(Date:8/27/2015)... Calif. , Aug. 27, 2015  Asterias Biotherapeutics, ... the emerging field of regenerative medicine, today announced that ... conferences in the month of September.  ... present at Rodman & Renshaw,s 17th Annual Global Investment ... PT at the St. Regis Hotel in ...
Breaking Biology Technology:Cuvette Manufacturer FireflySci Launches Back to School Deals with Complimentary Shipping On All Orders 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 2Capital Edge Consulting Makes Inc. 5000 List of America’s Fastest-Growing Private Companies 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 2Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 3Portage's Biohaven doses first human subject in Phase 1 trial with lead drug candidate BHV-0223 4Asterias Biotherapeutics to Present at Upcoming Investor Conferences 2
... There are signs the United States economy is cooling off ... the third quarter is not one of them, according to ... in 797 deals during the third quarter of 2006, which ... MoneyTree Report by PricewaterhouseCoopers and the ...
... Virent Energy Systems, Inc. has been awarded a ... and the Department of Energy to develop ... into a renewable chemical called propylene glycol. , ,The grant ... Research and Development Initiative , which was established to develop ...
... Commercial air service doesn't always please the business ... fundamental to enterprise than ever before. , ,That's ... dismiss the expenses of putting employees on planes ... and mixed-media communication tools. , ,The demands for ...
Cached Biology Technology:Venture capital above $6B for third straight quarter 2Venture capital above $6B for third straight quarter 3Virent lands $2M grant for chemical production 2IP video goes where air travel cannot 2IP video goes where air travel cannot 3
... expertise that made the original Gene Pulser apparatus ... available has been applied in the Gene Pulser ... modular design of the Gene Pulser II system ... that has the widest range of settings to ...
Caliper offers a wide array of standard LabChip products designed to be used in combination with our AMS 90 and LabChip 3000 microfluidic platforms....
... discovery system miniaturizes, integrates and automates ... LabChip technology, the LabChip 3000 performs ... flow fashion. LabChip assays are separations-based, ... what is achievable in homogenous, well-based ...
...
Biology Products: