Navigation Links
Physical reason for chromosome shape discovered
Date:1/14/2014

This work gives a solution to a fundamental question in structural biology: Why do metaphase chromosomes have their characteristic elongated cylindrical shape? The proposed solution is consistent with the structure of metaphase chromatin and with the nanomechanical properties of chromatin and chromosomes. It is a research at the interface between biology (higher order chromatin structure) and physical sciences (supramolecular structures and nanomaterials). This approach goes beyond the capabilities of current structural biology based on X-ray crystallography, because it allows the study of an enormous supramolecular assembly that cannot be crystallized. The work has been published in the Journal of the Royal Society Interface.

In the cell nucleus, genomic DNA molecules are associated with histone proteins and form long chromatin filaments containing many nucleosomes. Previous microscopy studies performed by researchers at the Chromatin Laboratory directed by professor Joan-Ramon Daban (Biosciences Unit of the Department of Biochemistry and Molecular Biology, UAB) showed that, during cell division, chromatin filaments are folded into multilayer planar structures. This discovery led to the thin-plate model in which it was proposed that condensed chromosomes are formed by many stacked layers of chromatin oriented perpendicular to the chromosome axis.

The measurements performed by professor Daban show that chromosomes of different animal and plant species exhibit great differences in size (which are dependent on the amount of DNA that they contain), but in all cases chromosomes are elongated cylinders that have relatively similar shape proportions (the length to diameter ratio is approximately 13). This study demonstrates that it is possible to explain this morphology by considering that chromosomes are self-organizing supramolecular structures formed by stacked layers of planar chromatin having different nucleosome-nucleosome interactio
'/>"/>

Contact: Joan-Ramon Daban
Joanramon.daban@uab.cat
34-935-811-616
Universitat Autonoma de Barcelona
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Increasing clarity for medics in suspected physical abuse cases
2. NIH-funded study examines use of mobile technology to improve diet and physical activity behavior
3. UTHealth study addresses barriers to physical activity counseling
4. Harvards Wyss Institute to develop smart suit that improves soldiers physical endurance
5. Iron, vitamins could affect physical fitness in adolescents
6. Childrens physical activity levels are not enough to counteract sedentary lifestyles
7. Biophysical Society names 5 2013 award recipients
8. Biophysical Society names 2013 Distinguished Service, Emily M. Gray, and Founders awardees
9. New study finds milk-drinking kids reap physical benefits later in life
10. Dark Energy: Life beneath the seafloor discussed at upcoming American Geophysical Union conference
11. UT study: Students who are more physically fit perform better academically
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Physical reason for chromosome shape discovered
(Date:2/5/2015)... , Feb. 3, 2015 Despite a ... from industries such as consumer electronics, automotive, storage ... surface mount technology (SMT) screen printers. Innovations in ... control will push the adoption curve up. Meanwhile, ... steady as glue dispensers are indispensable in the ...
(Date:1/22/2015)... Jan. 13, 2015  Today, FreeWavz ( www.FreeWavz.com ), ... crowdfunding campaign on Fundable, https://www.fundable.com/freewavz . FreeWavz ... production capacity to meet customer demand. ... http://photos.prnewswire.com/prnh/20150113/168790 Invented by ...
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication ... success of the Wocket™ smart wallet at CES 2015 in ... as one of the "11 Hot Products at CES" in a review ... So Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" ...
Breaking Biology News(10 mins):End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 2End-user Demand Spurs Global SMT Screen Printers and Glue Dispensers Market 3FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... PORTLAND, Ore. -- Pediatric neuroscientists at Oregon Health & ... use high magnetic field strength MRI to reveal tiny ... using standard MRI. Early, accurate identification of ... delays in therapy and enable physicians to inform families ...
... Steven B. Abramson, MD, senior vice president and vice ... Departments of Medicine and Pathology at NYU Langone Medical ... American College of Rheumatology (ACR) & Association of Rheumatology ... Chicago. The Distinguished Basic Investigator Award is a ...
... the RIKEN Brain Science Institute (BSI) have discovered a ... proteins from the cell. Their findings indicate that the ... the phosphorylation of a protein called p62, opening the ... as Huntington,s disease and Alzheimer,s disease. One of ...
Cached Biology News:First use of high-field MRI in developing brain reveals previously undetectable injuries 2Steven B. Abramson, MD, receives distinguished Basic Investigator Award at ACR 2011 2
(Date:2/27/2015)... , Feb. 27, 2015  Steep Hill, the ... US and internationally, intends to open a full service ... New Mexico , bringing advanced scientific tools and ... Steep Hill is currently the only laboratory ... conduct potency and contaminant testing in order to meet ...
(Date:2/26/2015)... , Feb. 26, 2015 S&P Capital ... Factual Stock Report coverage on MabVax Therapeutics Holdings Inc ... is a clinical stage biotechnology company focused on the ... medical needs in the treatment of cancer. MabVax has ... on the protective immune responses generated by patients who ...
(Date:2/26/2015)... MOUNTAIN VIEW, Calif. , Feb. 26, 2015 /PRNewswire/ ... appointment of Kate Black as Privacy Officer ... international, federal, and state privacy laws as well as ... and regulatory team, she will be responsible for reviewing, ... for customers in the U.S. and abroad. She joined ...
(Date:2/26/2015)... LEXINGTON, Mass., Feb. 26, 2015   Synageva ... a biopharmaceutical company developing therapeutic products for rare ... and provided 2015 goals, other key objectives, and ... conference call today at 4:30 p.m. EST to ... business update.  To participate in today,s call by ...
Breaking Biology Technology:Steep Hill First to Receive Provisional Approval to Establish Laboratory Services for Cannabis Testing in State of New Mexico 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 2S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 3S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 4S&P Capital IQ Initiates Coverage on MabVax Therapeutics Holdings Inc. in S&P Capital IQ Factual Stock Reports 523andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2Synageva BioPharma Reports 2014 Full Year Financial Results 2Synageva BioPharma Reports 2014 Full Year Financial Results 3Synageva BioPharma Reports 2014 Full Year Financial Results 4Synageva BioPharma Reports 2014 Full Year Financial Results 5Synageva BioPharma Reports 2014 Full Year Financial Results 6Synageva BioPharma Reports 2014 Full Year Financial Results 7Synageva BioPharma Reports 2014 Full Year Financial Results 8Synageva BioPharma Reports 2014 Full Year Financial Results 9
... Intercell,s IXIARO, the first licensed vaccine against Japanese ... -- This final decision follows the positive opinion ... in December 2008VIENNA, April 2 Intercell AG ... to prevent Japanese Encephalitis, IXIARO(R), has been approved ...
... for detection of methicillin-resistant Staphylococcus aureus for better patient ... its new LightCycler(R) test for the detection of methicillin-resistant ... the CE Mark, allowing it to be sold for ... Advanced Test is a qualitative in vitro ...
... - Conference Call Scheduled for Today at 5:00 p.m. ... Sunesis Pharmaceuticals, Inc. (Nasdaq: SNSS ) ... fiscal year ended December 31, 2008.Total revenue for the ... a net loss of $37.2 million. As of December ...
Cached Biology Technology:Intercell Announces European Approval of New Vaccine, IXIARO(R), to Prevent Japanese Encephalitis 2Intercell Announces European Approval of New Vaccine, IXIARO(R), to Prevent Japanese Encephalitis 3Intercell Announces European Approval of New Vaccine, IXIARO(R), to Prevent Japanese Encephalitis 4Roche to Introduce New LightCycler(R) MRSA Advanced Test in the EU 2Roche to Introduce New LightCycler(R) MRSA Advanced Test in the EU 3Roche to Introduce New LightCycler(R) MRSA Advanced Test in the EU 4Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 2Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 3Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 4Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 5Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 6Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 7Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 8Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 9Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 10Sunesis Pharmaceuticals Reports Fourth Quarter and Full-Year 2008 Financial Results 11