Navigation Links
Phage hunting students publish in PLoS ONE
Date:4/25/2011

one is quite sure whether they are alive in any practical sense). There are thought to be 1031 virus particles floating about,and 1023 phage infections a second.

Most specialize in infecting a particular species of bacteria. For the class the host bacterium was Mycobacterium smegmatis, which is related to the bacteria that cause leprosy and tuberculosis, but does not itself cause disease.

Because it is a fast grower, M. smegmatis has become a laboratory workhorse.

About 70 phages that prey on mycobacteria have been previously described. The authors of the PloS ONE paper, who were then freshmen at 12 colleges and universities, reported the isolation, sequencing, and annotation (labeling parts of the genome whose function is known) of 18 new ones.

Angelica and Uncle Howie

The new mycobacteriaphages included two found by the WUSTL students. One, named Angelica, was isolated from soil in Clayton, Mo. The other, called Uncle Howie, was isolated from soil in University City, Mo. Both Clayton and University City are suburbs of St. Louis.

(The students have "naming rights" for the phage they isolate. Consequently, other phage also have amusing names, including Corndog, Fruitloop, Tweety, Predator and Gumball. )

Most of the new phages, including the two St. Louis ones, had what is called siphoviral morphologieslong flexible non-contractile tails, and isometric icosahedral heads.

Once the students had sequenced the phages, they set out to compare their genomes to those of other phages. Bacteriophage genomes are mosaics or assemblages of modules, each of which corresponds to a gene or group of genes.

Since the phages are thought to have evolved by the exchange of these modules, comparing phages can provide clues to their evolutionary history.

The mycobacteriophages seem to fall into nine major clusters, with a few leftovers, or singletons, with no close relatives. Angelica, the Clayton
'/>"/>

Contact: Diana Lutz
dlutz@wustl.edu
314-935-5272
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. H. Pylori bacteria may help prevent some esophageal cancers
2. Genetic predictors of esophageal cancer identified
3. New study overturns orthodoxy on how macrophages kill bacteria
4. University of Saskatchewan and Canadian Synchrotron researchers shed light on esophageal disease
5. Macrophages: The defense cells that help throughout the body
6. Researchers describe first functioning lipidome of mouse macrophage
7. Effect of 6 mT SMF on phagocytosis depends on macrophage differentiation degree
8. Esophageal cancer risk lower than expected for patients with GERD
9. Pitt researchers describe molecular 2-step leading to protein clumps of Huntingtons disease
10. New therapeutic strategy could target toxic protein in most patients with Huntingtons disease
11. Small molecules might block mutant protein production in Huntingtons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... is entering what is described by the Volunteer Wildfire ... The Eastern Cape provincial government warned residents in certain ... winds and veld fires. A high veld fire ... along the coast in the Great Kei and Mnquma ... and during thunderstorms. The thunderstorms bring lightning strikes ...
(Date:8/27/2014)... to pay a premium for fruits, vegetables and other ... label claims is another matter. Now scientists studying conventional ... make sure farms are labelling their produce appropriately. Their ... and Food Chemistry , could help prevent organic food ... Safety Authority and the Wuerzburg University note that the ...
(Date:8/27/2014)... have shown that excessive iron is closely ... Previous studies from Chunyan Guo and co-workers ... shown that baicalin prevented iron accumulation after ... 1 expression, and increased ferroportin 1 expression ... disease rats. However, the relationship between iron ...
Breaking Biology News(10 mins):
... 2010, a Cathay Pacific Airways plane was arriving in Hong ... was forced to make a hard landinginjuring dozens. The potential ... diesel fuel is increasing as biodiesel becomes more popular and ... store and transport the two types of fuels. ...
... , This news release is available in ... of things -- be it the grains of sand on a beach, ... use a part of the brain that is organized topographically, researchers have ... "numerosity" assessment are laid out in a shape that allows those most ...
... A team of researchers led by Charles D. Nichols, ... Center New Orleans, has successfully translated a new technology ... flies. This powerful genetic tool Designer Receptors ... selectively, rapidly, reversibly, and dose-dependently remotely control behaviors and ...
Cached Biology News:University of Tennessee professor and student develop device to detect biodiesel contamination 2Finally mapped: The brain region that distinguishes bits from bounty 2Finally mapped: The brain region that distinguishes bits from bounty 3LSUHSC researchers develop new system to better study behavior, cell function 2
(Date:8/27/2014)... Aug. 27, 2014 Research and Markets ... Isotope Ratio Mass Spectrometer Industry Report 2014" report ... Isotope Ratio Mass Spectrometer Industry Report 2014 is a ... the global isotope ratio mass spectrometer industry. ... including definitions, classifications, applications and industry chain structure. The ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 BIOEQUA, an ... through the use of a handheld spray, has made ... United States. , The brand began with an ... researchers were surprised to learn that the application of ... extremely small and delivered directly to skin's basal layer. ...
(Date:8/27/2014)... (PRWEB) August 27, 2014 WriteResult, LLC ... – has once again shown superiority when it comes ... by completing the ePRO portion of their most recent ... The Japan-based pharma chose WriteResult’s digital writing platform to ... – the first to complete drew data from a ...
(Date:8/26/2014)... Bellingham, WA (PRWEB) August 26, 2014 ... visions for next-generation wearable technology, and inspiration for ... highlights at this year’s brighter, busier SPIE ... California, Convention Center. More than 4,400 international scientists, ... conferences, courses, an exhibition, and industry sessions sponsored ...
Breaking Biology Technology:Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4
... Seeks to Develop New Prescription Adult Cough Products Using ... Lipocine,s Proprietary Lip,ral(TM) Technologies, CHESTER, N.J. ... Inc. (Nasdaq: ARxT ) and Lipocine Inc., a,privately- ... technologies to address key unmet drug delivery and,therapeutics needs, ...
... Over 20 new speakers will,grace the faculty ... Analysis" conference in two weeks in New Jersey. ... Business Analysis, and Market,Forecasting executives; 200 from the ... attend the meeting. Competition has never been fiercer ...
... be Used to Accurately Measure Cardiac Output ... Cardiopulmonary Exercise Testing (CPX), WASHINGTON, September 19 Cheetah ... output monitoring, announced at HFSA the results of the study,"Markers ... The study, led by Dr. Jon Myers of Stanford ...
Cached Biology Technology:Adams Respiratory Therapeutics and Lipocine Enter into License and Collaboration Agreement 2Adams Respiratory Therapeutics and Lipocine Enter into License and Collaboration Agreement 3New Competitive Intelligence Speakers Spark Interest in Pharmaceutical Conference on October 1-2 in NJ 2Cheetah Medical's NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting 2Cheetah Medical's NICOM Non-Invasive Cardiac Output Monitor Featured in a Presentation at the Heart Failure Society of America (HFSA) Annual Meeting 3
... fragment based screening project: , ... 96 shape-diverse mixtures of 4 (5 uL each) , ... , Individual compounds are dissolved in DMSO ... mM. Supplied in 5 96-well trays. Dilute library ...
... interferons are cytopathic effect inhibition assays, also ... The neutralization assay measures the antibody's ability ... cytokine. Sample types include; tissue culture supernatents; ... assays, one unit is defined as the ...
... G bind specifically to Fc regions of ... G conjugates are commonly used as affinity ... subtypes from serum, hybridoma ascites fluids, tissue ... reagents are also commonly used to capture ...
... SYS203 is a complete, flexible system ... small samples, as is frequently required ... designed around Instechs miniature Clark-style polarographic ... inch in diameter (3.2 mm), it ...
Biology Products: