Navigation Links
Personalized medicine eliminates need for drug in 2 children
Date:1/31/2013

pertension induced by fludrocortisone and allowing the patients and their family to feel more confident about the origin of the disease, the investigators' discovery made it possible to reduce by as much as $10,000 the health costs for patients with this type of adrenal insufficiency. Over a 70-year lifespan, this is what the fludrocortisone treatment and the blood tests required in the patients treated with it adds up to.

The physicians did not modify the treatment earlier in the children's lives due to lack of a clear molecular diagnosis hence an imperfect understanding of the disease. Not only could withholding one of the replacement hormones have potentially led to a fatal outcome, but also analyzing the whole genome that led to the diagnosis would have been unthinkable just a few years ago. "Due to the astronomical costs associated previously with analyzing the whole genome, certain genes had to be targeted that were potentially responsible for the disorder and only these genes were analyzed in spite of the risk of not finding the right gene," explains Dr. Samuels, a researcher in human genetics. Today, lower genome analysis costs make an analysis of the whole genome affordable.

Description of the study

The two children in the study were hospitalized at the ages of 4 months or 4 years respectively, for hypoglycemia and associated convulsions. A diagnosis of adrenal insufficiency was made and the two children were saved by administering replacement hormones. Their ACTH (the pituitary hormone that controls the adrenal gland) blood concentrations were very high, which seemed to implicate the adrenal gland. The adrenal gland produces two vital hormones: cortisol to regulate glycemia and aldosterone to control minerals. When in doubt, in the event of adrenal insufficiency, both hormone types (cortisol and fludrocortisone, an aldosterone analogue) are prescribed. Nevertheless, fludrocortisone treatment can lead to side effects such as hyp
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Report from the front lines of personalized reproductive medicine revolution
2. BodyMedia & FitOrbit Up the Ante in Personalized Weight Loss
3. Study advances use of stem cells in personalized medicine
4. Scanning innovation can improve personalized medicine
5. Privately owned genetic databases may hinder diagnosis and bar the way to the arrival of personalized medicine
6. How to Differentiate Your Pharmaceutical Product in the Personalized Medicine Segment
7. Creating a future of personalized medicine: U-M forms joint venture for DNA diagnostics
8. Chromosomal translocations point the way toward personalized cancer care
9. Advances in personalized medicine for lung cancer
10. Beers bitter compounds could help brew new medicines
11. Microdosing: Updating its role in developing new medicines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... 29, 2014  Securus Technologies, a leading ... solutions for public safety, investigation, corrections and ... exciting enhancements to its THREADS™ product, which ... actionable intelligence and focused leads for investigators. ... technological innovation through identifying and delivering solutions ...
(Date:10/29/2014)... 2014, Beaverton, OR) New research presented at ... Conference in Houston, TX showed for the first ... infection in women using a readily available nutritional ... presented by Dr. Judith A. Smith, Pharm.D., associate ... Reproductive Sciences at The University of Texas Health ...
(Date:10/29/2014)... An overwhelming number of chemicals from household and industrial ... in our bodies. But for most of them, scientists ... Now they,ve taken the first step toward doing that ... most. Their new method is published in the ACS ... F. Wambaugh and colleagues note that the risks to ...
Breaking Biology News(10 mins):Securus Technologies Adds Advanced Features to Its Industry-Leading Investigative Analytics Product 2HPV infections in women eradicated by AHCC, Japanese mushroom extract 2
... of New South Wales have cautioned that more ... to the disinfecting properties of silver nano-particles, increasingly ... nanosilver has effective antimicrobial properties against certain pathogens, ... harmful organisms to rapidly adapt and flourish, a ...
... 8 May 2013 (Geneva, Switzerland) - Strategies for pursuing ... at higher CD4 counts and innovative models for HIV ... programme announced today. , "Functional cures" and the benefits ... this year and the IAS 20I3 conference, the worlds ...
... York City,s Central Park to Golden Gate Park in San ... of carbon, an environmental service with an estimated value of ... Annual net carbon uptake by these trees is ... benefit. In the study published recently in the journal ...
Cached Biology News:Bacteria adapt and evade nanosilver's sting -- new study 2IAS 2013 conference program live online 2IAS 2013 conference program live online 3US urban trees store carbon, provide billions in economic value 2US urban trees store carbon, provide billions in economic value 3US urban trees store carbon, provide billions in economic value 4US urban trees store carbon, provide billions in economic value 5US urban trees store carbon, provide billions in economic value 6
(Date:10/30/2014)... Isis Pharmaceuticals, Inc. (NASDAQ: ISIS ), ... present a company overview at the Nomura Biotechnology Conference on ... Boston, MA. A live webcast ... Media" section of the Company,s website, www.isispharm.com .  A ... hours and will be archived for a limited time. ...
(Date:10/30/2014)... 30, 2014  Regado Biosciences, Inc. (Nasdaq: ... conference call and live audio webcast on Thursday, November ... third quarter 2014 financial results. Interested participants ... (888) 347-1165 for domestic callers or (412) 902-4276 for ... under the investor relations section of the Regado website ...
(Date:10/30/2014)... flooding that devastated a wide swath of Colorado last ... roads and other infrastructure had been upgraded or modernized, ... Colorado Denver. , "People need to understand the importance ... professor of structural engineering at the CU Denver College ... study. "There is an assumption that a bridge will ...
(Date:10/27/2014)... The new research report, “Gas Insulated Switchgear ... (Primary & Secondary), and End-User (Transmission & Distribution, ... Generation) - Trends and Forecasts to 2019”, defines ... forecasting of the market size. , Browse more ... spread through 146 Pages and in-depth TOC on ...
Breaking Biology Technology:Isis Pharmaceuticals to Present at the Nomura Biotechnology Conference 2Regado Biosciences to Provide Third Quarter 2014 Financial Results 2CU Denver study says upgrading infrastructure could reduce flood damage 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... Inc.,announced today that it has been awarded a ... Research (SBIR) grant, entitled,"Long-Acting Beta Interferon for Multiple ... Stroke (NINDS) of The National,Institutes of Health (NIH). ... the achievement of certain research milestones., George ...
... scientific and business development flexibility, TSX Exchange ... Resverlogix Corp.,("Resverlogix") (TSX:RVX) announced today that it has ... USD$17.3 million debenture., Donald McCaffrey, President and ... volatile and challenging for companies,around the globe. This ...
... begin after markets close at 2:00 p.m. PT ... ... MASI ), the inventor of Pulse CO-Oximetry and,Measure-Through-Motion- and-Low-Perfusion pulse oximetry, today ... 2008 after the market closes on Monday, October 27, 2008., A ...
Cached Biology Technology:Bolder BioTechnology Receives $1.6 million NIH Grant to Continue Development of Multiple Sclerosis Drug 2Resverlogix Eliminates Sixty Percent of Remaining Debt 2Masimo to Report Third Quarter 2008 Financial Results on October 27, 2008 2
... Arrays can be used to test the ... and sera that are commonly used as ... contains spots for 21 different protein preparations ... antibody crossreactivity and species specificity, QC of ...
... the experimental process of determining the nucleotide ... DNA Sequencing is based on Sangers enzymatic ... allows cycle sequencing reactions. The resulting fluorescent ... capillary instrument controlled by a computer and ...
... On-Demand Cytometry The Guava EasyCyte ... laser based multiparameter cytometer with built-in 96-well ... can screen plates of cells and compounds ... manipulating multiple tubes or having the carryover ...
... and finishing services are tailored to ... large-scale 5' screening or full length ... experience with large-scale genome projects and ... ideal cDNA outsourcing solution. In addition, ...
Biology Products: