Navigation Links
Penn team uses self-assembly to make molecule-sized particles with patches of charge
Date:10/20/2009

PHILADELPHIA - Physicists, chemists and engineers at the University of Pennsylvania have demonstrated a novel method for the controlled formation of patchy particles, using charged, self-assembling molecules that may one day serve as drug-delivery vehicles to combat disease and perhaps be used in small batteries that store and release charge.

Researchers demonstrated that the positive electrical charges of calcium ions just like the calcium in teeth and bone can form bridges between negatively charged polymers that would normally repel each other. The polymers, similar to the lipids that make the membranes surrounding living cells, have both a water-loving part linked to a water-repelling part. On the surfaces of these cell-sized polymer sacks, the calcium ions create calcium-rich islands or patches on top of negatively-charged polymer. Copper ions also work, and the patches can be made to coalesce and cover half of the particle. This polarized structure is the basic arrangement needed to set up, for example, the two electrodes of a microscopic battery. They could also one day be functionalized into docking sites to enhance targeted delivery of drug-laden particles to cells.

While the concept seems simple, that opposite charges attract, the creation and control of patches on one small particle has been a challenge. Scientists like Dennis E. Discher, principal investigator of the study and a professor of chemical and biomolecular engineering at Penn, are designing materials at the nanoscale because future technologies will increasingly rely on structures with distinct and controlled surfaces. Physicians, for example, will improve medical therapies by wrapping drugs within the bioengineered polymer sacks, or by creating tiny biomedical sensors. Green energy production and storage will also require structures with scales no longer measured by inches, but by micrometers and nanometers.

The collaboration involved faculty from Penn's
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clemson bioengineer uses nanoparticles to target drugs
2. Do dust particles curb climate change?
3. Therapeutic nanoparticles give new meaning to sugar-coating medicine
4. Carbon nanoparticles toxic to adult fruit flies but benign to young
5. New insights into health and environmental effects of carbon nanoparticles
6. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
7. University of Leicester researchers discover new fluorescent silicon nanoparticles
8. New nanoparticles could revolutionize therapeutic drug discovery
9. Shape matters in the case of cobalt nanoparticles
10. UCSD researchers make first direct observations of biological particles in high-altitude ice clouds
11. To fight drug addiction, UB researchers target the brain with nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... , Dec. 18, 2014 Research and Markets ... of the "Micro Market Monitor: North America Perimeter ... http://photos.prnewswire.com/prnh/20130307/600769 The ... at a CAGR of 3.6% from 2014 to 2019. ... this market, Canada is expected ...
(Date:12/19/2014)... --  LaunchKey , the first decentralized mobile authentication and ... Things era, today announced the close of $3 million ... by Metamorphic Ventures with participation from ENIAC Ventures, Crosslink ... LaunchKey has raised $4 million to date, and will ... bring LaunchKey to market in 2015. LaunchKey ...
(Date:12/17/2014)... BELVOIR, Va. , Dec. 15, 2014 /PRNewswire-USNewswire/ ... efforts to make it easier to detect and ... chain. Today the agency started performing ... The capability will validate the authenticity of purchased ... chain. The new quality control measures will be ...
Breaking Biology News(10 mins):Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 2Micro Market Monitor: North America Perimeter Security Systems Market (Intrusion Detection Sensor, Video Surveillance, Communication/Alarm and Notification, Access Control System) 3LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 2LaunchKey Raises $3 Million in Additional Funding Led by Metamorphic Ventures 3Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3
... Service filed with the Federal Register today a proposed ... by fishermen and gourmets alike, as endangered under the ... Fisheries Service considered the report of a scientific review ... extinction. The scientific review team reported ...
... 9, 2008 Not enough American women understand that ... help prevent serious birth defects, and only 40 percent ... beginning before pregnancy, two recent surveys show. ... pregnancy is crucial because birth defects of the brain ...
... are developing a tiny sensor that could be used ... industrial chemicals and chemical warfare agents, much more quickly ... common techniques of gas chromatography and mass spectrometry and ... of a computer mouse. Eventually, the team, led by ...
Cached Biology News:New folic acid seal helps women choose enriched grain foods to help prevent birth defects 2New folic acid seal helps women choose enriched grain foods to help prevent birth defects 3MIT gas sensor is tiny, quick 2
(Date:12/19/2014)... December 18, 2014 Ed Bilsky, Ph.D., ... the Center for Excellence in the Neurosciences (CEN), and ... has been selected as a member of the prestigious ... first neuroscientist from Maine to receive this honor. , ... supported entirely by the Dana Foundation. Its mission ...
(Date:12/19/2014)... 2014 With only 2 weeks left ... on Sartorius Biohit products . The product specials include ... Electronic Pipette Trade-in Program, and free pipette tips. , ... around the world. They are ideal for lab technicians ... ,     Full volume range of 0.1 uL ...
(Date:12/17/2014)... 2014 The Activated Carbon Manufacturing ... is why IBISWorld updated its original industry research report. ... from an intensified focus on environmental policy. Over the ... standards for power plants and a range of other ... Industry Analyst Sarah Kahn, “a range of downstream industrial ...
(Date:12/17/2014)... 2014 Once more, EMAAR has ... packaged waste water treatment plant to phase one of ... (KAEC). Two years ago Bioshaft successfully supplied and operated ... two residential towers with an occupancy of 900 residences. ... million gallons per day and was signed on September ...
Breaking Biology Technology:UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 2Activated Carbon Manufacturing in the US Industry Market Research Report Has Been Updated from IBISWorld 3
... The United States Food & Drug,Administration (FDA) today approved a ... HIV-1 Group M RNA, hepatitis C RNA and hepatitis B,DNA ... TaqScreen MPX,Test for use on the cobas s 201 system, ... HIV-1 Group M RNA, HIV-1 Group O RNA,HIV-2 RNA, hepatitis ...
... Common Stock to Remain Listed While it , ... Technologies, Inc. (NYSE Alternext US: PTN) today reported it ... formerly known as the American Stock Exchange), advising Palatin ... of the Exchange,s continued listing standards under Section 1003 ...
... Biosciences Corporation (Nasdaq: MATK ) announced today that ... 11th Annual Growth Conference in New York City. The ... York Palace Hotel. Peter L. Buzy, CFO will be ... Time.A live audio webcast of Martek,s presentation can be accessed ...
Cached Biology Technology:FDA Approves Most Comprehensive System to Test Donated Blood for HIV, Hepatitis B & Hepatitis C 2FDA Approves Most Comprehensive System to Test Donated Blood for HIV, Hepatitis B & Hepatitis C 3Palatin Technologies Receives Notification Letter from NYSE Alternext US 2Palatin Technologies Receives Notification Letter from NYSE Alternext US 3
... Fixed Angle Polypropylene Rotor designed for ... Centra CL3/CL3R** and Centra-MP4/MP4R*. A translucent ... /MP4, ,EXCLUSIVE polypropylene rotor design provides ... repeatedly autoclaved. Polypropylene rotors are ...
... Xcise is a powerful technology platform that ... analysis. High quality sample preparation can ... , The Xcise is a powerful technology ... throughput proteome analysis. It combines the functions ...
Request Info...
... compatible with hood installations. ... system for 384-well plates, ... prepares large quantities of ... Wellpro also performs plate ...
Biology Products: