Navigation Links
Penn team uses self-assembly to make molecule-sized particles with patches of charge
Date:10/20/2009

PHILADELPHIA - Physicists, chemists and engineers at the University of Pennsylvania have demonstrated a novel method for the controlled formation of patchy particles, using charged, self-assembling molecules that may one day serve as drug-delivery vehicles to combat disease and perhaps be used in small batteries that store and release charge.

Researchers demonstrated that the positive electrical charges of calcium ions just like the calcium in teeth and bone can form bridges between negatively charged polymers that would normally repel each other. The polymers, similar to the lipids that make the membranes surrounding living cells, have both a water-loving part linked to a water-repelling part. On the surfaces of these cell-sized polymer sacks, the calcium ions create calcium-rich islands or patches on top of negatively-charged polymer. Copper ions also work, and the patches can be made to coalesce and cover half of the particle. This polarized structure is the basic arrangement needed to set up, for example, the two electrodes of a microscopic battery. They could also one day be functionalized into docking sites to enhance targeted delivery of drug-laden particles to cells.

While the concept seems simple, that opposite charges attract, the creation and control of patches on one small particle has been a challenge. Scientists like Dennis E. Discher, principal investigator of the study and a professor of chemical and biomolecular engineering at Penn, are designing materials at the nanoscale because future technologies will increasingly rely on structures with distinct and controlled surfaces. Physicians, for example, will improve medical therapies by wrapping drugs within the bioengineered polymer sacks, or by creating tiny biomedical sensors. Green energy production and storage will also require structures with scales no longer measured by inches, but by micrometers and nanometers.

The collaboration involved faculty from Penn's
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clemson bioengineer uses nanoparticles to target drugs
2. Do dust particles curb climate change?
3. Therapeutic nanoparticles give new meaning to sugar-coating medicine
4. Carbon nanoparticles toxic to adult fruit flies but benign to young
5. New insights into health and environmental effects of carbon nanoparticles
6. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
7. University of Leicester researchers discover new fluorescent silicon nanoparticles
8. New nanoparticles could revolutionize therapeutic drug discovery
9. Shape matters in the case of cobalt nanoparticles
10. UCSD researchers make first direct observations of biological particles in high-altitude ice clouds
11. To fight drug addiction, UB researchers target the brain with nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... number of chemicals from household and industrial products are ... bodies. But for most of them, scientists have yet ... taken the first step toward doing that by estimating ... new method is published in the ACS journal ... and colleagues note that the risks to human health ...
(Date:10/29/2014)... in German . ... and Peter Schlögelhofer at the Max F. Perutz Laboratories ... University of Vienna dived into the process of meiosis ... display an inversion of the standard meiotic phases. The ... Nature Communications . , Meiosis is the two-step ...
(Date:10/29/2014)... all organisms in the living world compete with ... strongly in how much they invest into their ... eager to get access to high-quality resources, while ... use of the lower-quality resources that are left ... in animal and human societies seems to fluctuate ...
Breaking Biology News(10 mins):Meiotic cell division 'the other way round' 2Evolution of competitiveness 2Evolution of competitiveness 3
... used in California,s Central Valley, one of the world,s ... frog species miles from farmland. Writing in Environmental ... Pacific Tree Fogs in remote mountain areas, including national ... pesticides by the elements. California,s Central Valley is ...
... 25, 2013 The following statement is being issued by Robbins Geller ... Pacific Biosciences Securities Litigation SUPERIOR COURT OF THE ... IN RE PACIFIC BIOSCIENCES OF CALIFORNIA ... CIV509210 SUMMARY NOTICE OF PROPOSED SETTLEMENT OF CLASS ACTION Hon. Marie ...
... researchers have developed a computer-aided method that uses ... rapid advances toward personalized health care, disease management ... V. Chawla and his doctoral student, Darcy A. ... Recommendation Engine (CARE) for personalized disease risk predictions ...
Cached Biology News:Pesticides contaminate frogs from Californian National Parks 2Robbins Geller Rudman & Dowd LLP and Scott+Scott, Attorneys at Law, LLP Announce Proposed Settlement of Class Action in the Pacific Biosciences Securities Litigation 2Robbins Geller Rudman & Dowd LLP and Scott+Scott, Attorneys at Law, LLP Announce Proposed Settlement of Class Action in the Pacific Biosciences Securities Litigation 3Robbins Geller Rudman & Dowd LLP and Scott+Scott, Attorneys at Law, LLP Announce Proposed Settlement of Class Action in the Pacific Biosciences Securities Litigation 4Notre Dame researchers develop system that uses a big data approach to personalized healthcare 2
(Date:10/30/2014)...  Regado Biosciences, Inc. (Nasdaq: RGDO ), ... and live audio webcast on Thursday, November 6, 2014, ... 2014 financial results. Interested participants and investors ... for domestic callers or (412) 902-4276 for international callers. ... investor relations section of the Regado website at ...
(Date:10/27/2014)... 27, 2014 The new research ... (High & Medium), Sub-type (Primary & Secondary), and ... & Transportation & Power Generation) - Trends and ... market with analysis and forecasting of the market ... Tables with 52 Figures spread through 146 Pages ...
(Date:10/27/2014)... 2014 The “Molecular Diagnostic Market ... Technology (PCR, INAAT, DNA Sequencing), End User (Hospital, ... - Global Forecast to 2018” provides a detailed ... current market trends, and strategies impacting the global ... forecasts of the revenue and share analysis. , ...
(Date:10/27/2014)... Mass. , Oct. 27, 2014 ... "Company"), a worldwide leader in the development and ... the life sciences research market, today announced that ... presented a novel, accurate, highly reproducible, and robust ... – routine high-throughput protein analysis on small needle ...
Breaking Biology Technology:Regado Biosciences to Provide Third Quarter 2014 Financial Results 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 2Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 3Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 4Global Molecular Diagnostics Market Will Reach $7.9 Billion by 2018 - New Research Report by MarketsandMarkets 5Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 4Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 5
... EXTON, Pa., June 2, 2011 Morphotek®, Inc., a ... commenced a multi-center, phase II study of MORAb-004 for ... MORAb-004, a potentially first-in-class monoclonal antibody that specifically binds ... therapy comparing its safety and therapeutic activity at two ...
... a medical explanation for why exercise is good for the ... that started in Dr. Ian Phillips, lab at Keck Graduate ... 29 that keeps hearts healthy even under intense exercise. ... of why exercise is good for you," said Phillips, KGI,s ...
... (NASDAQ: SQNM ), a life sciences company ... its subsidiary Sequenom Center for Molecular Medicine® (Sequenom CMM) ... Valley Bank’s San Diego-based team. Sequenom will use proceeds ... of new products and other near term growth initiatives. ...
Cached Biology Technology:Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 2Morphotek®, Inc. Announces Initiation of MORAb-004 Phase II Study in Melanoma 3Scientists Discover Gene Regulator That Helps Hearts Through Exercise 2Sequenom Enters Into New $30.0 Million Credit Facility 2Sequenom Enters Into New $30.0 Million Credit Facility 3Sequenom Enters Into New $30.0 Million Credit Facility 4
This antibody detects an ~25 kDa band, corresponding to the expected molecular mass of Rab3A, on immunoblots. The antibody specificity is confirmed in peptide inhibition immunoblotting studies....
... reactive against the complex IV assembly factor SURF1. ... cultured cells. SURF1 is an important assembly factor ... participate in the folding of subunit II and ... SURF1, particularly ones that result in an absence ...
100 g monoclonal antibody which can immunocapture ~10 g of Complex IV from heart mitochondria. Also included are 2 mg of bovine heart mitochondria for control immunocapture....
Rabbit polyclonal to GPR56 ( Abpromise for all tested applications). entrezGeneID: 9289 SwissProtID: Q9Y653...
Biology Products: