Navigation Links
Penn team uses self-assembly to make molecule-sized particles with patches of charge
Date:10/20/2009

PHILADELPHIA - Physicists, chemists and engineers at the University of Pennsylvania have demonstrated a novel method for the controlled formation of patchy particles, using charged, self-assembling molecules that may one day serve as drug-delivery vehicles to combat disease and perhaps be used in small batteries that store and release charge.

Researchers demonstrated that the positive electrical charges of calcium ions just like the calcium in teeth and bone can form bridges between negatively charged polymers that would normally repel each other. The polymers, similar to the lipids that make the membranes surrounding living cells, have both a water-loving part linked to a water-repelling part. On the surfaces of these cell-sized polymer sacks, the calcium ions create calcium-rich islands or patches on top of negatively-charged polymer. Copper ions also work, and the patches can be made to coalesce and cover half of the particle. This polarized structure is the basic arrangement needed to set up, for example, the two electrodes of a microscopic battery. They could also one day be functionalized into docking sites to enhance targeted delivery of drug-laden particles to cells.

While the concept seems simple, that opposite charges attract, the creation and control of patches on one small particle has been a challenge. Scientists like Dennis E. Discher, principal investigator of the study and a professor of chemical and biomolecular engineering at Penn, are designing materials at the nanoscale because future technologies will increasingly rely on structures with distinct and controlled surfaces. Physicians, for example, will improve medical therapies by wrapping drugs within the bioengineered polymer sacks, or by creating tiny biomedical sensors. Green energy production and storage will also require structures with scales no longer measured by inches, but by micrometers and nanometers.

The collaboration involved faculty from Penn's
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. Clemson bioengineer uses nanoparticles to target drugs
2. Do dust particles curb climate change?
3. Therapeutic nanoparticles give new meaning to sugar-coating medicine
4. Carbon nanoparticles toxic to adult fruit flies but benign to young
5. New insights into health and environmental effects of carbon nanoparticles
6. Facile synthesis of nanoparticles with multiple functions advanced in Singapore
7. University of Leicester researchers discover new fluorescent silicon nanoparticles
8. New nanoparticles could revolutionize therapeutic drug discovery
9. Shape matters in the case of cobalt nanoparticles
10. UCSD researchers make first direct observations of biological particles in high-altitude ice clouds
11. To fight drug addiction, UB researchers target the brain with nanoparticles
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/15/2014)... biophysics textbook and it describes how life functions and ... into biological systems and provides an understanding of the ... how our genes make proteins that control the dynamics ... an organism. It quantifies the principles of life and ... on both large and small scales. The book is ...
(Date:10/15/2014)... Ebola virus is spreading rapidly and to an unexpected ... in the past and the virus shows a new ... recorded before. For this reason, the German National Academy ... Science and Engineering, and the Union of the German ... on the Ebola epidemic today. , In the statement ...
(Date:10/15/2014)... , Oct. 15, 2014 NXT-ID, Inc. (NASDAQ: ... authentication company focused on the growing mobile commerce market releases photos ... in Times Square on Monday October 13 th . ... David Tunnel and angel investor Mr. Chad A. ... , CEO of NXT-ID thanked his investors and employees "for their ...
Breaking Biology News(10 mins):New book about life as seen from physics 2Academies call for consequences from the Ebola virus epidemic 2Academies call for consequences from the Ebola virus epidemic 3Academies call for consequences from the Ebola virus epidemic 4Academies call for consequences from the Ebola virus epidemic 5Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 2Photo Release: NXT-ID Inc. Rings Opening Bell of the NASDAQ Stock Market October 13th 3
... University of Michigan researchers and their colleagues recently hastened ... trees in a large-scale, long-term experiment to glimpse the ... bark was stripped from each tree to kill it ... the federally funded experiment Forest Accelerated Succession Experiment (FASET) ...
... of Pacific Islands Forestry have submitted a proposal to ... strawberry guava, a South American tree that has invaded ... in 1825 as a garden plant. The scientists are ... and Natural Resources, and Hawai Department of Agriculture, agencies ...
... May 25, 2008, approaching 5 p.m. PDT, NASA scientists will ... because at that time the Phoenix Mars Mission space vehicle ... a soft landing onto the northern Mars terrain called Green ... the Red Planet. The place got its name after analysis ...
Cached Biology News:U-M scientists remove thousands of aspens to glimpse forest's future 2U-M scientists remove thousands of aspens to glimpse forest's future 3Insect release proposed to control exotic strawberry guava 2Phoenix mission to Mars will search for climate clues 2Phoenix mission to Mars will search for climate clues 3
(Date:10/22/2014)... 22, 2014 Nuvilex, Inc. (OTCQB: NVLX) – ... people worldwide are living with diabetes, with  that number ... The global market for diabetes treatments is approximately $500 ... worldwide died from pancreatic cancer.  Pancreatic cancer is the ... in the United States , and ...
(Date:10/20/2014)... Convey Computer , the leader in ... State University won first place in the 2014 ... the team’s solution achieved the highest overall performance in ... place finisher. , Experts from all segments of the ... challenge, using a variety of design tools, hardware and ...
(Date:10/20/2014)... 20, 2014 PureTech , a science ... healthcare problems, announced today the closing of a ... from Invesco Perpetual, a $120 Billion group of ... PureTech,s existing pipeline forward and to advance new ... scientific creativity to really go for the big ...
(Date:10/19/2014)... (PRWEB) October 20, 2014 ... Industry Meeting (ABIM). ABIM will take ... More information about ABIM 2014 is now ... , Delegates representing companies and organizations from ... and obtain information on the latest products ...
Breaking Biology Technology:Nuvilex Brief Analyst Report: Thinking Outside the Box by BrokerBank Securities, Inc. 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 2Team from Iowa State Wins 2014 MemoCODE Design Contest Using Convey HC-2ex 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6
... decision last week to merge its Imaging and Printing Group ... Systems Group (IPSG) is a major milestone in HPs journey ... combining these two units, HP has a unified and convincing ... may be the key that turns HPs consumer message into ...
... researchers will show off developments in games that offer real-world ... ,The Academic Advanced Distributed Learning Co-Laboratory , WTN and ... how Games are Shaping Business and Learning, which will center ... applied to the workforce. , ,The video game industry has ...
... Business is booming again at the University of Wisconsin-Madisons ... job-seekers. , ,This is the best hiring situation weve seen ... associate director of ECS . Fall 2004 recruiting was ... are expected to attend Career Connection, the colleges spring job ...
Cached Biology Technology:HP charges toward the living room 2HP charges toward the living room 3Businesses and educators to preview video games for training 2Businesses and educators to preview video games for training 3Companies recruiting more UW engineering students 2Companies recruiting more UW engineering students 3Companies recruiting more UW engineering students 4
Glycerokinase; from Bacillus stearothermophilus...
... The inductive drives of VARIOMAG Magnetic ... as motors, belts, or mechanical bearings, making ... In addition, the VARIOMAG inductive drive can ... water, dust or microorganisms. This is why ...
...
... FL is equipped with ... measurement technologies that complement ... advanced features of Fluoroskan ... Fluoroskan Ascent FL provides ...
Biology Products: