Navigation Links
Penn researchers identify molecular link between gut microbes and intestinal health
Date:11/3/2013

PHILADELPHIA - It's well established that humans maintain a symbiotic relationship with the trillions of beneficial microbes that colonize their bodies. These organisms, collectively called the microbiota, help digest food, maintain the immune system, fend off pathogens, and more. There exists a long and growing list of diseases associated with changes in the composition or diversity of these bacterial populations, including cancer, diabetes, obesity, asthma, and even autism.

Inflammatory bowel disease (IBD) is one of the best-studied diseases associated with alterations in the composition of beneficial bacterial populations. However, the nature of that relationship, and how it is maintained, has yet to be clarified.

Now, researchers at the Perelman School of Medicine at the University of Pennsylvania have identified a molecule that appears to play a starring role in this process.

David Artis PhD, associate professor of Microbiology, and colleagues report in Nature that the enzyme HDAC3 is a key mediator in maintaining proper intestinal integrity and function in the presence of friendly bacteria. What's more, HDAC3 and the genetic pathways it controls appears critical to maintaining a healthy balance between intestinal microbes and their host.

"HDAC3 in intestinal epithelial cells regulates the relationship between commensal bacteria and mammalian intestine physiology," says first author Theresa Alenghat VMD PhD, instructor in the Department of Microbiology.

That humans rely on their microbial cohabitants is hardly news. Much normal human physiology is attributable to our relationship to our microbiota.

The question that Alenghat and Artis and their colleagues wanted to answer is, "What are the molecular mechanisms that control this relationship, and how is it that this relationship goes wrong and can contribute to metabolic and inflammatory diseases?"

The team focused their effor
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Researchers Able to Identify that Benign Tumors from Use of Oral Contraceptive Have a Greater Chance of Becoming Malignant
2. Children of lower socioeconomic status grow up more susceptible to catching colds, Carnegie Mellon researchers find
3. University of Louisville researchers sign global licensing agreement
4. BUSM researchers study epigenetic mechanisms of tumor metastasis for improved cancer therapy
5. Researchers quantify toxic ocean conditions during major extinction 93.9 million years ago
6. Researchers discover how cancer invisibility cloak works
7. Oregon researchers say supplement cuts muscle loss in knee replacements
8. BUSM researchers identify molecule that could aid lung cancer detection, treatment
9. Researchers identify gene variant that raises risk for colorectal cancer from eating processed meat
10. Researchers show how plants tell the time
11. Berkeley Lab researchers get a detailed look at a DNA repair protein in action
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn researchers identify molecular link between gut microbes and intestinal health
(Date:9/30/2014)... Pollution in urban and farm runoff in Hawaii is ... finds. , The study, published Tuesday in the ... in the runoff ends up in algae that the ... animals, eyes, flippers and internal organs. , Scientists at ... Oceanic and Atmospheric Administration (NOAA) conducted the study to ...
(Date:9/30/2014)... . , Animals ... such as exposure to predators. Researchers from the Max ... study on different populations of great tits that risk-taking ... High metabolic rates and low temperatures were associated with ... more likely to approach potential predators. , The readiness ...
(Date:9/29/2014)... of gut bacteria called Clostridium ramosum , coupled with ... work is published this week in mBio , the ... , A research team from the German Institute of Human ... bacteria including C. ramosum gained weight when fed ... ramosum were less obese even when consuming a high-fat ...
Breaking Biology News(10 mins):Pollution linked to lethal sea turtle tumors 2Pollution linked to lethal sea turtle tumors 3Risky metabolism 2Gut bacteria promote obesity in mice 2
... NIH-supported scientists will be presenting their latest research findings ... Research in Otolaryngology (ARO). When: February 19-23, 2011 ... Additional Information: Research topics to be presented by scientists ... Communication Disorders (NIDCD) will include: Deafness ...
... will disappear by 2200 as a result of warming ... says a new study by the University of Colorado ... The carbon resides in permanently frozen ground ... warming temperatures, which will impact not only the climate ...
... Scientists are reporting for the first time that ... potential to act as endocrine disruptors, which can interfere ... is not caused by microcystin toxins, long recognized as ... yet unidentified substances. As a result, the scientists are ...
Cached Biology News:NIDCD research at ARO Midwinter Meeting 2NIDCD research at ARO Midwinter Meeting 3NIDCD research at ARO Midwinter Meeting 4NIDCD research at ARO Midwinter Meeting 5NIDCD research at ARO Midwinter Meeting 6NIDCD research at ARO Midwinter Meeting 7Thawing permafrost likely will accelerate global warming 2Thawing permafrost likely will accelerate global warming 3
(Date:10/2/2014)... New York (PRWEB) October 02, 2014 ... to announce funding received to investigate therapeutics directed ... disease. A grant award from the Small Business ... (NIA), National Institutes of Health (NIH) is entitled ... Therapeutics." The company also received a SBIR Matching ...
(Date:10/2/2014)... MO (PRWEB) October 02, 2014 Permian ... business in the St. Louis, Missouri, area on October ... has become a leading plastic injection molder in the ... machines and is a supplier to many Fortune 500 ... customer support every step of the way, from concept ...
(Date:10/2/2014)... 02, 2014 At a time when many ... has introduced a new kind of squeeze aimed at ... the Scienceware® Squeeze Rite™ Wash Bottle , catalog no. ... within the bottle reduces the waste of reagents, solutions and ... liquids. , “Easier to squeeze when compared to standard 500ml ...
(Date:10/2/2014)...  NKT Therapeutics today announced that the U.S. ... designation to NKTT120, the company,s lead therapeutic being ... NKTT120 is a humanized monoclonal antibody that specifically ... has been demonstrated to be a key mediator ... cell disease.  Fast Track designation is intended to ...
Breaking Biology Technology:Gismo Therapeutics Inc. Awarded Grants to Develop New Alzheimer's Disease Therapeutics 2Gismo Therapeutics Inc. Awarded Grants to Develop New Alzheimer's Disease Therapeutics 3Permian Plastics LLC Celebrates 20 Years As Leading Manufacturer of Plastic Molds 2New Wash Bottle Reduces Waste of Reagents, Solutions, and Other Liquids 2FDA Grants Fast Track Designation to NKT Therapeutics' NKTT120 for the Treatment of Sickle Cell Disease 2
... article profiling the significant rise in valuation of ... is true product innovation through focused R&D efforts that's currently ... valuation. , ,While Genentech had revenues of $4.6 billion in ... ,This surpasses Amgen's top position of $72.2 billion, is pretty ...
... and the Endpoint Exchange Network said on Tuesday ... be able to exchange check data and images, starting with ... an IT service provider claiming 4,000 financial clients. Endpoint Exchange ... Metavante , the technology arm of Marshall & Ilsley ...
... Corp. said on Wednesday it has agreed to buy ... spinoff, for $600 million in cash. , ,Bone Care and ... $2 billion and almost 7,000 employees worldwide, plan to complete ... reported healthy quarterly profits and revenues. Bone Care tallied its ...
Cached Biology Technology:Drug innovation beats marketing, patents and mergers 2Massachusetts firm to buy UW spinoff Bone Care for $600 million 2Massachusetts firm to buy UW spinoff Bone Care for $600 million 3
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
Form: Ready to use Applications: ELISA...
Form: Ready to use Applications: ELISA...
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble...
Biology Products: