Navigation Links
Penn research points to new way of preserving fertility for boys undergoing cancer treatment
Date:3/28/2012

PHILADELPHIA Treatments for childhood cancers are increasingly successful with cure rates approaching 80%, but success often comes with a downside for the surviving men: the cancer treatments they received as boys can leave them sterile as adults. Now, a research team led by Ralph Brinster of the University of Pennsylvania School of Veterinary Medicine has completed a 14-year experiment that gives hope for a technique that could restore their fertility.

Brinster is the Richard King Mellon Professor of Reproductive Physiology at Penn Vet and was recently awarded the National Medal of Science for his lifetime of research on the genetics of the mammalian germline, the cells that give rise to sperm and eggs.

In his most recent research, Brinster collaborated with fellow members of the Department of Animal Biology at Penn Vet, with members of the Department of Cell and Developmental Biology at Penn's Perelman School of Medicine and with the Penn Bioinformatics Core.

Their study was published in the journal Human Reproduction.

For males, fertility begins with spermatogonial stem cells, which are present at birth, embedded in the basement membrane of the testes' seminiferous tubules. As a boy approaches puberty, these cells begin to make daughter cells that eventually become sperm. While they normally continue this process throughout a post-pubescent man's life, factors like radiation and chemotherapy drugs can destroy them, rendering him sterile.

About 1 in 3 boys surviving childhood cancer will be in danger of having severely decreased fertility as an adult; as many as 1 in 5,000 men of reproductive age currently suffer this serious quality-of-life problem as a result. Adult men who undergo cancer treatment that might damage their fertility can preemptively freeze their sperm, an option not available to pre-pubescent boys. But if a sample of a boy's spermatogonial stem cells could be extracted and preserved befo
'/>"/>

Contact: Evan Lerner
elerner@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... JOSE, Calif. , July 27, 2015 /PRNewswire/ ... developer of human interface solutions, today announced that ... ® touchscreen solution for its stylish smartwatch. ... for its proven reliability, low power and highly ... a wet finger. Huawei designers also required a ...
(Date:7/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ... "Global Outlook of the Biometrics Industry 2015 " ... The global biometrics market is likely to witness ... owing to the uptake of multiple technologies available. ... enhances the growth of biometrics in existing applications ...
(Date:7/21/2015)... NEW YORK , July 21, 2015 /PRNewswire/ ... critical systems, as seen in the recent U.S. ... enterprises a solution to the infosec conundrum, but ... data is stored. To address this dilemma, Biometrics-as-a-Service ... of its Biometric Tokenization SDK for third party ...
Breaking Biology News(10 mins):Synaptics Touchscreen Solution Powers New Huawei Watch 2Synaptics Touchscreen Solution Powers New Huawei Watch 3Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4
... in the two chromosomes has given scientists a break ... College of Georgia researchers report. It,s also helped ... no sense of smell, said Dr. Lawrence C. Layman, ... and Genetics. The WRD11 gene interacts with a ...
... The National Institute of General Medical Sciences (NIGMS) ... of Yeshiva University a five-year, $30 million grant to ... important proteins. "Determining the structures of proteins is ... biological processes as well as in disease pathways," says ...
... An Australian study of identical twins shows that a rare ... mutation that occurs in the embryo, and not necessarily passed ... University of Melbourne and Austin Health and published in the ... Director of the Comprehensive Epilepsy Program at Austin Health and ...
Cached Biology News:Chromosomal break gives scientists a break in finding new puberty gene 2Chromosomal break gives scientists a break in finding new puberty gene 3Einstein receives $30 million to study protein form and function 2Einstein receives $30 million to study protein form and function 3Einstein receives $30 million to study protein form and function 4
(Date:8/5/2015)... NEW YORK , Aug. 5, 2015 /PRNewswire/ ... clinical-stage drug development company based on open innovation, ... enrolled in an innovative ulcerative colitis clinical trial ... conventional patient site visits with data collected using ... telemonitoring, remote video visits with clinical trial staff ...
(Date:8/4/2015)... Carolina (PRWEB) , ... August 05, 2015 , ... ... edition of the “Product Handbook – the complete product line.” The handbook ... components. , “This new product handbook consolidates our complete standard product offering into ...
(Date:8/4/2015)... , Aug. 4, 2015 Trigemina, Inc., a ... non-narcotic, nasally delivered, analgesic drug products, announced today that ... the position of chief medical officer. Dr. Kori brings ... much of which has been focused in the neuroscience ... add Dr. Kori to our clinical team given his ...
(Date:8/4/2015)... , Aug. 4, 2015  Natera, Inc. (Nasdaq: ... the analysis of circulating cell-free DNA, today announced that ... June 30, 2015 after the market close on August ... webcast at 1:30 p.m. PT (4:30 p.m. ET) to ... Second Quarter 2015 Results Conference Call  Date: , Wednesday, ...
Breaking Biology Technology:Transparency Life Sciences Announces Start Of Ulcerative Colitis Clinical Trial Assessing Feasibility Of Decentralized Patient Data Collection 2Transparency Life Sciences Announces Start Of Ulcerative Colitis Clinical Trial Assessing Feasibility Of Decentralized Patient Data Collection 3Transparency Life Sciences Announces Start Of Ulcerative Colitis Clinical Trial Assessing Feasibility Of Decentralized Patient Data Collection 4Spirax Sarco releases Product Handbook 2Trigemina Appoints Dr. Shashi Kori to the Position of Chief Medical Officer 2Trigemina Appoints Dr. Shashi Kori to the Position of Chief Medical Officer 3Natera to Release Second Quarter 2015 Results on August 12, 2015 2
... 3, 2008 ,Pharmacyclics, Inc. (Nasdaq: PCYC ) ... autoimmune disease drug candidates at the,American Association for ... 12-16, 2008, at the San Diego Convention Center ... the company,s histone deacetylase(HDAC),inhibitor, which is now in ...
... from the National Institute of Standards and Technology (NIST) ... atoms of a rare-earth element, erbium, to within two ... novel trapping and laser cooling technique. Their recent report* ... cool and manipulate individual atoms of erbium, an element ...
... BioSpace, the world,s,leading online bioscience job board and ... Career Fair on Tuesday, May 6, 2008. The,event will ... 2 pm to 7,pm., Life science professionals from ... meet face to face with leading biotech and,pharmaceutical companies. ...
Cached Biology Technology:Pharmacyclics Announces Multiple Presentations at the American Association for Cancer Research Annual Meeting 2Pharmacyclics Announces Multiple Presentations at the American Association for Cancer Research Annual Meeting 3Pharmacyclics Announces Multiple Presentations at the American Association for Cancer Research Annual Meeting 4Bon MOT: Innovative atom trap catches highly magnetic atoms 2Bioscience Career Fair in San Francisco Projected to Break Job Seeker Attendance Records 2
Fast, sensitive quantitation of total MEK 1/2 concentration....
Argon Calibration Source...
RayBio Human Chemokine Antibody Array 1.1 (8) with Accessory, detects 38 chemokine factors (for lysate) Class: Antibody Array Products Product Group: Antibody Array...
Vybrant® Multidrug Resistance Assay Kit...
Biology Products: