Navigation Links
Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
Date:9/26/2008

PHILADELPHIA - Biophysicists at the University of Pennsylvania have used 3,200 computer processors and long-established data on cholesterol's role in the function of proteins to clarify the mysterious interaction between cholesterol and neurotransmitter receptors. The results provide a new model of behavior for the nicotinic acetylcholine receptor, a well studied protein involved in inflammation, Alzheimer's disease, Parkinson's disease, schizophrenia, epilepsy, the effect of general anesthetics and addiction to alcohol, nicotine and cocaine.

Moreover, the results apply to closely related receptors that bind serotonin and GABA, which are neurotransmitters directly involved in regulation of mood and sleep.

The findings have broad implications for, among other fields, pharmacology. Drug development in this arena has to take into account the structure and chemical makeup of this receptor, both of which researchers now say were incomplete. Drugs acting on the receptor have been thought to interact with the protein as though it were isolated.

Now, researchers believe that drugs binding to the receptor not only interact with amino acids the building blocks of the protein receptor but also cholesterol tucked away within the protein. The shift in thinking transforms the understanding of this receptor in many ways, from shape and structure to its interaction with its environment and its response to neurotransmitters. The new model should spark a reexamination of several decades of research on the receptor's structure and function.

Researchers demonstrated that the receptor, also know as nAChR, contains internal sites capable of containing cholesterol which serve to stabilize the protein's structure. Furthermore, molecular simulations revealed that both surface sites and deeply buried sites within the protein require cholesterol, which directly supports contacts between the agonist-binding domain and the pores that are thought to
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Iowa State wins $18.5M grant to create NSF Center for Biorenewable Chemicals
2. Tel Aviv University researchers create new stem cell screening tool
3. Researchers devise means to create blood by identifying earliest stem cells
4. Caltech scientists create DNA tubes with programmable sizes for nanoscale manufacturing
5. Engineers create bone that blends into tendons
6. Researchers create safer alternative to heparin
7. MSU to create genomic clearinghouse for biofuel crops
8. Gladstone scientists create Wikipathways to foster research collaboration
9. Engineers create 3-D model to help biologists combat blue tongue virus
10. UT Southwestern researchers create molecule that nudges nerve stem cells to mature
11. MIT creates new material for fuel cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
(Date:11/18/2014)... 18, 2014   EyeLock Inc. , a ... MorphoTrust USA (Safran), a leading U.S. ... a strategic partnership to offer comprehensive biometric identity ... (MVA), airport screening and financial services markets. ... serves consumers through a nationwide network of 1,100 ...
(Date:11/7/2014)... professor, biomedical engineering, in the Grove School of ... have identified a molecule that could lead to ... forms of breast cancer. , Triple negative breast ... to aggressive proliferation and metastasis and a lack ... discovered the overexpression of intercellular adhesion molecule-1 (ICAM-1) ...
(Date:11/6/2014)... when that predator runs so fast that it essentially blinds ... the fastest creature on Earth. Some of these half-inch-long beetles ... miles per hour). The fastest human can do about five ... beetle, a person would have to hit 480 miles per ... peak speeds, everything becomes a blur. They can,t gather enough ...
Breaking Biology News(10 mins):EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3The tiger beetle: Too fast to see 2
... Scientists will soon be exploring matter at temperatures and ... microseconds using powerful pulsed lasers. Matter in such states ... kilometres beneath the surface, and also in elusive "warm ... X-ray beamline ID24 at the European Synchrotron Radiation Facility ...
... , SAN FRANCISCO (Nov. 9, 2011; 12:50 p.m.) ... an investigational intravenous antiplatelet, showed patients can be "bridged" ... oral antiplatelet drugs until they undergo cardiac surgery. ... inhibition known to be associated with a low risk ...
... use of genetic analysis to help save a boy imperiled ... change in two localities, and on the secret lives of ... AAAS Kavli Science Journalism Awards. The awards, administered by ... for distinguished reporting for a general audience. The Kavli Foundation ...
Cached Biology News:Exploring the last white spot on Earth 2Exploring the last white spot on Earth 3Scripps Health/the Medicines Company announce late breaking BRIDGE trial results presented at TCT 2Winners named for the 2011 AAAS Kavli Science Journalism Awards 2Winners named for the 2011 AAAS Kavli Science Journalism Awards 3Winners named for the 2011 AAAS Kavli Science Journalism Awards 4Winners named for the 2011 AAAS Kavli Science Journalism Awards 5Winners named for the 2011 AAAS Kavli Science Journalism Awards 6Winners named for the 2011 AAAS Kavli Science Journalism Awards 7Winners named for the 2011 AAAS Kavli Science Journalism Awards 8Winners named for the 2011 AAAS Kavli Science Journalism Awards 9
(Date:11/21/2014)... Diego, CA (PRWEB) November 20, 2014 ... extended their Sartorius Entris Balance promotion . The ... customers seeking a durable, high accuracy, and easy-to-maintain balance ... made in Germany. It was designed to help customer’s ... affordable and a balance that is very durable. Sartorius ...
(Date:11/21/2014)... 2014 The California Healthcare ... organization representing leading California academic institutions, biotechnology, medical ... US today released a report revealing that ... growth. The trend shows a 4 percent increase ... Biomedical Industry Report indicates that, while biopharmaceutical ...
(Date:11/21/2014)... The November 2014 issue of BioTechniques ( ... journal featuring the following articles:, , ... in the retina , DNA from fingermarks ... chromogenic substrates in zebrafish , Re-use of ... , Nuclear LC3-positive puncta in stressed cells ...
(Date:11/21/2014)... 2014 Why did Stephen Hawking become ... so instantly recognizable? Why have they become icons to ... author Hilton Ratcliffe seeks out the answers to those ... to do with science. In " Stephen Hawking Smoked ... 21, 2014), Ratcliffe puts it plainly: , “It ...
Breaking Biology Technology:Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 2“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 3“Stephen Hawking Smoked My Socks” Sparks Controversy in Science World 4
... Presented, CHARLES TOWN, W.Va., Nov. 23 ... a provider of treatment for,diabetic peripheral neuropathy ... concluded analysis of the recent volatility of ... Board of Directors., (Logo: http://www.newscom.com/cgi-bin/prnh/20061128/REBUILDERLOGO ...
... AMDL, Inc. (Amex: ADL,- News), headquartered ... and Jilin, China, through its wholly owned ... biopharma company that,engages in the development, manufacture ... The Company announced today that,the recent presentation ...
... University of Pittsburgh have created the best method so ... wide, a significant step in science,s increasing attempts to ... single molecule scale and provide smaller, faster, and more ... 26 in the Journal of the American Chemical Society ...
Cached Biology Technology:ReBuilder Medical Technologies, Inc.'s Recent Stock Price Volatility Explained 2AMDL Presentation of China Success Story from Rodman & Renshaw Annual Healthcare Conference Available at WallStreetReporter.com 2
... Mediated Purification with an Affinity Chitin-binding Tag) ... protein splicing elements (termed inteins) to purify ... (1-4) (Figures 1 and 2). This system ... by its ability to separate a recombinant ...
... Kit provides the reagents to efficiently ... skeletal myotubes. By efficiently promoting myogenic ... tool in studies examining myogenesis, transcription ... for muscle cell replacement therapy. By ...
The Saturn 2200 answers your GC/MS questions with the CP-3800 GC and the 2000 Series Ion Trap MS! These components create a platform for the worlds most versatile GC and flexible MS. Both deliver une...
... of E-PAGE Gels easier and more efficient ... and several types of pre-cut pre-assembled membrane/filter ... x 13.5 cm E-PAGE Gels*. The available ... for western transfer of proteins (Figure 1 ...
Biology Products: