Navigation Links
Penn biologists determine microRNA activity is suppressed in mouse ovum
Date:2/3/2010

PHILADELPHIA - Biologists at the University of Pennsylvania studying oocytes in mice, the immature egg cells necessary for sexual reproduction, have demonstrated an unusual behavior in microRNA, or miRNA, activity that may be the first event in reprogramming the differentiated oocyte into pluripotent blastomeres of the embryo. MicroRNAs are a member of the family of small RNAs, the so-called dark matter of the biological world.

MicroRNAs imperfectly pair with untranslated regions of RNA and mediate translational repression and mRNA degradationhallmarks of the gene expression process. The Dicer enzyme, which generates small RNAs in the miRNA and RNA interference pathways, is essential for meiotic maturation of mouse oocytes.

The scientists found that the mRNA population in oocytes lacking Dicer was not enriched in miRNA binding sites, implicating a weak impact of miRNAs on regulating mRNA stability. To explore further this possibility, the scientists injected a reporter transcript, a message RNA that is not a normally present in the oocyte but contained sequences that would interact with miRNAs in the oocyte. In somatic cells, such a message would be degraded and suppressed by micro RNA. However, in oocytes, there is minimal translational repression and no degradation of the message. The finding that this pathway does not operate in oocytes is most surprising because miRNAs are implicated in controlling cell differentiation.

The data, according to researchers, presents a puzzling paradox. "Although mouse oocytes produce miRNAs, their mRNA targets are poorly repressed," said Richard Schultz, associate dean for the natural sciences and the Charles and William L. Day Distinguished Professor of Biology in Penn's School of Arts and Sciences. "Reducing miRNA activity during oocyte growth may have two roles. First, the low activity of miRNA-mediated mRNA degradation, perhaps linked to the absence of P bodies (structures that are implicated as
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. CCNY biologists identify new spiny pocket mouse species
2. Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
3. Biologists merge methods, results from different disciplines to find new meaning in old data
4. New handbook for biologists who need more competence or confidence in statistics
5. Biologists discover bacterial defense mechanism against aggressive oxygen
6. Beyond genomics, biologists and engineers decode the next frontier
7. Biologists, educators recognize excellence in evolution education
8. NIMBioS hosts tutorial on optimal control and optimization for biologists
9. Biologists discover death stench is a universal ancient warning signal
10. UTSA plant biologists publish where their peers are -- on the Web
11. Microbiologists find defense molecule that senses respiratory viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2015)... -- Aware, Inc. (NASDAQ: AWRE ), a leading supplier ... its second quarter ended June 30, 2015.  ... a decrease of 33% compared to $6.8 million in the ... of 2015 was $0.3 million, or $0.01 per diluted share, ... in the same period a year ago.  ...
(Date:7/21/2015)... Today, ZTE announced its Android smartphone Axon, ... expected revenues in 2015 that relate to sales of FPC1025 for ... approximately 2,200 MSEK for 2015. Jörgen Lantto, CEO of ... in China and we are proud that ... for Axon , its first ...
(Date:7/21/2015)... , July 21, 2015 Passwords have ... seen in the recent U.S. Office of Personnel ... to the infosec conundrum, but developers and end-users ... To address this dilemma, Biometrics-as-a-Service provider HYPR Corp. ... Tokenization SDK for third party integration. ...
Breaking Biology News(10 mins):Aware, Inc. Reports Second Quarter 2015 Financial Results 2Aware, Inc. Reports Second Quarter 2015 Financial Results 3Aware, Inc. Reports Second Quarter 2015 Financial Results 4Aware, Inc. Reports Second Quarter 2015 Financial Results 5Aware, Inc. Reports Second Quarter 2015 Financial Results 6FPC's Touch Fingerprint Sensor FPC1025 in ZTE's Smartphone Axon 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 2HYPR Corp. Launches Industry First Biometric Tokenization Platform 3HYPR Corp. Launches Industry First Biometric Tokenization Platform 4
... Colo., USA - The February 2014 Lithosphere ... travertine in the Rio Grande rift, central New Mexico; ... Australia; the first lithosphere-scale illustration of the structural evolution ... formation; evaluation of the central Garlock fault in Pilot ...
... David Allis, a pioneer in the field of epigenetics whose ... role in regulating the activity of individual genes, will be ... by the Japan Prize Foundation, was made at a press ... approximately half a million dollars, is among the most prestigious ...
... Institute,s Illinois Natural History Survey have found that overall, concentrations ... from the lower Illinois River do not appear to be ... The full results of the study have been published in ... mercury concentration in fillets was below the US Food and ...
Cached Biology News:Rio Grande fift, Rum Jungle complex, Black Sea, West Africa craton, California faults 2Rio Grande fift, Rum Jungle complex, Black Sea, West Africa craton, California faults 3Rio Grande fift, Rum Jungle complex, Black Sea, West Africa craton, California faults 4Rio Grande fift, Rum Jungle complex, Black Sea, West Africa craton, California faults 5David Allis, pioneer in epigenetics, to receive prestigious Japan Prize 2Research shows arsenic, mercury and selenium in Asian carp not a health concern to most 2
(Date:7/27/2015)... ... ... Production of high tenacity filament yarn of viscose rayon (excluding sewing thread) ... it surpassed the EUR 106 million mark (in value terms) in 2013, while it ... producer, while Italy is a key consumer. , The high tenacity filament yarn ...
(Date:7/27/2015)... 27, 2015   Inocucor Technologies Inc ., ... accelerators for farmers, has received a notice of ... for its patent application to protect Inocucor consortia ... and enhance yields on farms and in greenhouses. ... live IN-M1 microbial consortium and its fermentation byproducts, ...
(Date:7/27/2015)... ... 2015 , ... BlueInGreen® announced the addition of EnviroSales of ... world’s most efficient gas dissolution technology to all of Florida, excluding the panhandle. ... and municipal markets. With offices located in Sarasota, Sebring and Melbourne Beach, the ...
(Date:7/27/2015)... YORK , July 27, 2015 ... today announced the winners of its annual Klerman ... research by scientists who have been supported by ... career scientists to pursue innovative ideas in neurobiological ... "proof" of concept for the early detection, treatment, ...
Breaking Biology Technology:High Tenacity Filament Yarn of Viscose Rayon Consumption to Grow Swiftly in the EU, Forecasts BAC Reports in New Study Available at MarketPublishers.com 2Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 2Inocucor Technologies Receives Groundbreaking U.S. Patent for Proprietary Biological Processes that Stimulate Plant Growth 3BlueInGreen Brings Water Treatment Technology to Florida 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 2Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 3Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 4Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 5Brain & Behavior Research Foundation Names Winners of Klerman-Freedman Prizes for Exceptional Research 6
... ... company,s eCTD solution suite offering users a standalone Windows® desktop application for viewing eCTD submissions ... ... provider of electronic regulatory submission solutions for the life sciences industry, today announced the release ...
... time, physicists have convincingly demonstrated that physically separated ... The achievement is analogous to the quantum entanglement ... circuitry instead of photons in optical systems. ... to quantum computing and secure communications, but solid-state ...
... , , , , ... Biosys,Limited, based in Bangalore, an integrated Drug Discovery and Development,solution ... today that it has entered into a co-marketing agreement to,provide ... innovative cell based assay solutions for GPCR, Kinases,NHR and Proteases. ...
Cached Biology Technology:Datafarm Releases New Desktop-based Application for Multi-region Viewing of eCTD Submissions: Datafarm VUE 2DiscoveRx Corp. & Jubilant Biosys Limited Announce Co-Marketing Agreement for Screening Services 2DiscoveRx Corp. & Jubilant Biosys Limited Announce Co-Marketing Agreement for Screening Services 3
R26.4C...
... W x H): 17 3/4" x ... 12 slidesTime: Programmable 0 - 100 hoursControl: ... hybridization steps 40 user programmable protocols 3 ... temperature) Rapid temperature ramp-up from 37 - ...
Anti-DAP-1, Rabbit Monoclonal Immunogen: KLH-conjugated synthetic peptide corresponding to the C-terminal region of human DAP-1. Molecular Weight: 11 kDa Quality Assurance: Routinely eval...
Request Info...
Biology Products: