Navigation Links
Penn biologists determine microRNA activity is suppressed in mouse ovum
Date:2/3/2010

PHILADELPHIA - Biologists at the University of Pennsylvania studying oocytes in mice, the immature egg cells necessary for sexual reproduction, have demonstrated an unusual behavior in microRNA, or miRNA, activity that may be the first event in reprogramming the differentiated oocyte into pluripotent blastomeres of the embryo. MicroRNAs are a member of the family of small RNAs, the so-called dark matter of the biological world.

MicroRNAs imperfectly pair with untranslated regions of RNA and mediate translational repression and mRNA degradationhallmarks of the gene expression process. The Dicer enzyme, which generates small RNAs in the miRNA and RNA interference pathways, is essential for meiotic maturation of mouse oocytes.

The scientists found that the mRNA population in oocytes lacking Dicer was not enriched in miRNA binding sites, implicating a weak impact of miRNAs on regulating mRNA stability. To explore further this possibility, the scientists injected a reporter transcript, a message RNA that is not a normally present in the oocyte but contained sequences that would interact with miRNAs in the oocyte. In somatic cells, such a message would be degraded and suppressed by micro RNA. However, in oocytes, there is minimal translational repression and no degradation of the message. The finding that this pathway does not operate in oocytes is most surprising because miRNAs are implicated in controlling cell differentiation.

The data, according to researchers, presents a puzzling paradox. "Although mouse oocytes produce miRNAs, their mRNA targets are poorly repressed," said Richard Schultz, associate dean for the natural sciences and the Charles and William L. Day Distinguished Professor of Biology in Penn's School of Arts and Sciences. "Reducing miRNA activity during oocyte growth may have two roles. First, the low activity of miRNA-mediated mRNA degradation, perhaps linked to the absence of P bodies (structures that are implicated as
'/>"/>

Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

Page: 1 2

Related biology news :

1. CCNY biologists identify new spiny pocket mouse species
2. Penn biologists explain how organisms can tolerate mutations, yet adapt to environmental change
3. Biologists merge methods, results from different disciplines to find new meaning in old data
4. New handbook for biologists who need more competence or confidence in statistics
5. Biologists discover bacterial defense mechanism against aggressive oxygen
6. Beyond genomics, biologists and engineers decode the next frontier
7. Biologists, educators recognize excellence in evolution education
8. NIMBioS hosts tutorial on optimal control and optimization for biologists
9. Biologists discover death stench is a universal ancient warning signal
10. UTSA plant biologists publish where their peers are -- on the Web
11. Microbiologists find defense molecule that senses respiratory viruses
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/28/2014)... Norwegian explorer Roald Amundsen reached the South Pole in ... arrived long before any human. , Using data from ... the Antarctic continent, including the South Pole, a group ... (DRI) in Reno, Nevada, created the most accurate and ... southernmost continent. The new record, described in an article ...
(Date:7/28/2014)... ago, MIT professor John Essigmann and colleagues from the University ... They thought if they could induce the virus to mutate ... out a strategy that our immune system uses against ... which caused HIV to mutate at an enhanced rate, as ... in a small clinical trial reported in 2011. In a ...
(Date:7/28/2014)... the top 10 U.S. cities that have seen an ... as frequent road closures, overwhelmed storm drains and compromised ... NOAA technical report. , This nuisance flooding, caused by ... coasts, between 300 and 925 percent since the 1960s. ... Frequency Changes around the United States, also finds Annapolis ...
Breaking Biology News(10 mins):Lead pollution beat explorers to South Pole, persists today 2Lead pollution beat explorers to South Pole, persists today 3Forced mutations doom HIV 2Forced mutations doom HIV 3Forced mutations doom HIV 4NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 2NOAA: 'Nuisance flooding' an increasing problem as coastal sea levels rise 3
... bred to age too quickly seemed to have sipped from ... Pittsburgh School of Medicine injected them with stem cell-like progenitor ... of becoming infirm and dying early as untreated mice did, ... lived two to three times longer than expected, according to ...
... new study shows that deep brain stimulation (DBS) is ... patients with either unipolar major depressive disorder (MDD) or ... Online First by Archives of General Psychiatry , ... led by Helen S. Mayberg, MD, professor in the ...
... Millbrook, N.Y. -- On January 2nd, WAMC Northeast Public Radio ... new radio show called Earth Wise: A look at our ... among radio listeners, with a focus on raising awareness about ... segments will air Monday through Friday at 11:10 AM and ...
Cached Biology News:Pitt: A shot of young stem cells made rapidly aging mice live longer and healthier 2Deep brain stimulation shows promising results for unipolar and bipolar depression 2Deep brain stimulation shows promising results for unipolar and bipolar depression 3Cary Institute and WAMC debut new environment radio show 2
(Date:7/28/2014)... NEW YORK , July 28, 2014 /PRNewswire/ ... for ConvergeHEALTH by Deloitte , has been ... Data Interchange Standards Consortium, a non-profit working to ... research data, particularly as it relates to electronic ... to continue CDISC,s mission of collaborating with organizations ...
(Date:7/28/2014)... 2014 It’s a hard truth: Nearly half ... further their post-secondary education are failing to obtain a diploma ... year. And according to an analysis by The Resume ... students’ uninformed choice of college majors, which leads to underemployment, ... study: Some 51.7 percent of post-9/11 veterans using GI ...
(Date:7/28/2014)... -- Research and Markets has announced the addition ... report to their offering. http://photos.prnewswire.com/prnh/20130307/600769 ... used to determine the size of a particle in a ... analyze the size of particles as it can affect the ... to determine the behavior and nature of a material, and ...
(Date:7/25/2014)... 2014 Amgen (NASDAQ: AMGN ) ... $0.61 per share dividend for the third quarter of ... 2014, to all stockholders of record as of the ... About Amgen Amgen is committed to unlocking the ... by discovering, developing, manufacturing and delivering innovative human therapeutics. ...
Breaking Biology Technology:ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 2ConvergeHEALTH by Deloitte's David Hardison Named Chairman of the Clinical Data Interchange Standards Consortium 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 2Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 3Resume Place: To Choose the Best College Majors, Veterans Need Early Career Counseling, Data Shows 4Global Particle Size Analysis Market 2014-2018 2Amgen Announces 2014 Third Quarter Dividend 2Amgen Announces 2014 Third Quarter Dividend 3
... Approves Class Action Settlement, NORCROSS, Ga., ... ), the global leader in providing automated ... today that the,Securities and Exchange Commission (SEC) ... previously-disclosed investigation into certain,activities involving the company,s ...
... Educational Grants to Support the 25th Biennial Cornea Research Conference ... ... Meeting -, TAMPA, Fla., Sept. 28 ... of the advancement of ocular innovation through its,contributions of unrestricted educational ...
... FDA and Leading Pharmaceutical Companies Slated to ... ... (OTC Bulletin Board: PHST), a leading provider of software and,strategic services for ... Pharsight(R) Knowledgebase,Server(TM) (PKS(TM)) User Group Meeting on October 3 and 4, 2007 ...
Cached Biology Technology:Immucor Settles SEC Investigation 2Sirion Therapeutics Supports Ophthalmic Education 2Pharsight Hosts Fourth Annual PKS User Group Meeting 2Pharsight Hosts Fourth Annual PKS User Group Meeting 3
... Bruker Daltonics and Bruker BioSpins ... for metabolism studies, and analysis of ... ESI-TOF system, an optional Avance NMR ... acquisition, evaluation and statistical analysis for ...
... animal movements in a Morris Water Maze. ... a predefined sequence of trials.The Spatial Behavior line ... a video camera, frame grabber, and feature extraction ... once and up to 6 moving animals. ...
... Object Records behavior directed toward examining a novel ... a family of instruments all built around a ... and that can track two fields at once ... automatically extracts animal positions and records them, but ...
... Ultrapure ACS Reagent Grade C 19 H ... Weight: 691.95 PRODUCT SPECIFICATIONS Form: Powder Clarity ... pH 3.0 - Yellow pH ... tracking dye in agarose and acrylamide gel ...
Biology Products: