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Penn, Georgia collaboration awarded $14.6 million to expand pathogen database
Date:12/10/2009

few thousand dollars but the raw data for a single genome can generate terabytes of data, easily overwhelming a personal computer. Additional large-scale datasets supported by EuPathDB include DNA sequence polymorphisms from the wider population, chromosomal modifications, comprehensive studies on RNA transcription and protein expression, analysis of protein-protein interactions and metabolic pathways.

Consider a researcher working to develop a malaria vaccine. First, this scientist must identify which genes are active when the parasite is living in a human host, rather than when it lives in the mosquito. They must then determine which of those genes encodes protein antigens likely to be recognized by the immune system. By taking all of these factors into account plus many more the researcher can narrow the many thousands of genes in the parasite genome down to a few dozen candidates for further testing.

"It has been remarkable to witness the rapid growth of biomedical research in recent years, fueled by the genomic revolution" says Roos, "and it is particularly gratifying to see the impact of bioinformatics tools such as EuPathDB. By integrating diverse sources of information -- all the genes in the genome, all the proteins in the cell, all patient responses in a population -- these databases offer great promise for improved human health."


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Contact: Jordan Reese
jreese@upenn.edu
215-573-6604
University of Pennsylvania
Source:Eurekalert

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