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Penn, Georgia collaboration awarded $14.6 million to expand pathogen database
Date:12/10/2009

ing source of neurological birth defects. Toxoplasma and Neospora caninum are also economically important as sources of congenital infection in farm animals.
  • Trichomonas, a widespread cause of vaginitis in women.
  • The parasites responsible for kala azar (Leishmania), African sleeping sickness (Trypanosoma brucei), and Chagas disease (Trypanosoma cruzi), which have been incorporated into this resource with support from the Bill & Melinda Gates Foundation.

    The EuPathDB database is one of four Pathogen Bioinformatics Resource Centers supported by the NIH and is directed by principal investigator David S. Roos, E. Otis Kendall Professor of Biology in the School of Arts and Sciences at the University of Pennsylvania. Co-investigators include Christian Stoeckert of the School of Medicine at Penn and Jessica Kissinger of the University of Georgia. Roos and Stoeckert are also affiliated with the Penn Center for Bioinformatics and the Penn Genome Frontiers Institute, and Kissinger with the Center for Tropical and Emerging Global Diseases.

    Understanding the genes of an organism and how they are expressed is a critical first step in preventing or treating disease. EuPathDB provides researchers with a database that catalogues every accessible step in the chronicle of disease pathogenesis. This database and its component web sites have been used by more than 42,000 scientists over the past six months, from more than 100 countries worldwide. Meeting presentations and workshops help to ensure effective use of this resource by the scientific community.

    Advances in genome technology have dramatically increased both the scale and scope of information now available for human pathogens. For example, the first Plasmodium parasite genome sequence was completed in 2002 after six years of work and a cost of $35 million. Scientists can now sequence additional strains of the parasite in just a few days, for a
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  • Contact: Jordan Reese
    jreese@upenn.edu
    215-573-6604
    University of Pennsylvania
    Source:Eurekalert

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