Navigation Links
Peering into living cells -- without dye nor fluophore
Date:2/7/2013

In the world of microscopy, this advance is almost comparable to the leap from photography to live television. Two young EPFL researchers, Yann Cotte and Fatih Toy, have designed a device that combines holographic microscopy and computational image processing to observe living biological tissues at the nanoscale. Their research is being done under the supervision of Christian Depeursinge, head of the Microvision and Microdiagnostics Group in EPFL's School of Engineering.

Using their setup, three-dimensional images of living cells can be obtained in just a few minutes instantaneous operation is still in the works at an incredibly precise resolution of less than 100 nanometers, 1000 times smaller than the diameter of a human hair. And because they're able to do this without using contrast dyes or fluorescents, the experimental results don't run the risk of being distorted by the presence of foreign substances.

Being able to capture a living cell from every angle like this lays the groundwork for a whole new field of investigation. "We can observe in real time the reaction of a cell that is subjected to any kind of stimulus," explains Cotte. "This opens up all kinds of new opportunities, such as studying the effects of pharmaceutical substances at the scale of the individual cell, for example."

Watching a neuron grow

This month in Nature Photonics the researchers demonstrate the potential of their method by developing, image by image, the film of a growing neuron and the birth of a synapse, caught over the course of an hour at a rate of one image per minute. This work, which was carried out in collaboration with the Neuroenergetics and cellular dynamics laboratory in EPFL's Brain Mind Institute, directed by Pierre Magistretti, earned them an editorial in the prestigious journal. "Because we used a low-intensity laser, the influence of the light or heat on the cell is minimal," continues Cotte. "Our technique th
'/>"/>

Contact: Yann Cotte
yann.cotte@epfl.ch
41-216-937-012
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Protecting living fossil trees
2. Global Surgical Devices Market Growth Driven by Improving Standards of Living and Longer Life Expectancies, Research Shows
3. Molecular spectroscopy tracks living mammalian cells in real time as they differentiate
4. Nature: Microscope looks into cells of living fish
5. Living microprocessor tunes in to feedback
6. Photograph of a living human brain is the overall winner of Wellcome Image Awards 2012
7. Penn researchers improve living tissues with 3-D printed vascular networks made from sugar
8. Force of nature: Defining the mechanical mechanisms in living cells
9. A new look at proteins in living cells
10. Living power cables discovered
11. Watching the cogwheels of the biological clock in living cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Peering into living cells -- without dye nor fluophore
(Date:1/22/2015)... DUBLIN , Jan. 22, 2015 Research and Markets ... "Biometrics - A Global Market Overview" report to ... biometrics technology is to ensure that an individual is who ... technology may make use of a person,s unique physical characteristics, ...
(Date:1/22/2015)... TORONTO , Jan. 13, 2015 /PRNewswire/ - Today, FindBiometrics, the ... announced the launch of its new website design. ... in its infancy", says Peter O,Neill , founder and ... ever, the industry needs involvement from the key players on ...
(Date:1/22/2015)... , Jan. 13, 2015 Technology Showcase, Hall E - ... authentication solutions, today announced it will showcase its EyeLock ID ... by the Department of Energy,s Oak Ridge National Laboratory ... Show . EyeLock,s iris identity authentication technology is being used ...
Breaking Biology News(10 mins):Biometrics - A Global Market Overview 2Biometrics - A Global Market Overview 3Identity Industry Leading Publication Debuts New Look As Biometrics Hit Mainstream 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 2EyeLock Debuts First Iris Authentication Technology Embedded in 3D Printed Automobile 3
... Hopkins University and Yale University have discovered that a ... in blood vessels throughout the body, sensing small molecules ... to these molecules by increasing blood pressure. The finding ... the body,s complex system for maintaining a stable blood ...
... University (Spain) have created a high resolution atlas of the ... demonstrates that an average image of an organ along with ... individual cases and differentiating healthy forms from pathologies. "This ... its components such as the ventricles and the atrium ...
... some of the world,s worst pollution. Until now, however, information ... to that pollution human-caused nitrogen emissions was lacking. ... Stanford Woods Institute senior fellow Peter Vitousek reveals that amounts ... and water in China by way of rain, dust and ...
Cached Biology News:Blood vessels 'sniff' gut microbes to regulate blood pressure 2Blood vessels 'sniff' gut microbes to regulate blood pressure 3An atlas of the human heart is drawn using statistics 2Stanford scientists help shed light on key component of China's pollution problem 2
(Date:3/5/2015)... Va. , March 5, 2015   HX360 ... as semi-finalists in the HX360 Innovation Challenge ... entries, will compete to be chosen as one of ... panel of senior health system executives and venture capitalists ... HX360 Innovation Challenge takes place at the 2015 HIMSS ...
(Date:3/5/2015)... York (PRWEB) March 05, 2015 LifeCell ... to be able to get an Advanced Semen Analysis ... stress, blaming and guessing are all risk factors for ... the woman is the source of the infertility. Infertility ... LifeCell Dx has the simplest, least complicated and ...
(Date:3/5/2015)... 2015 Plant disease specialists from around ... the Annual Meeting of The American Phytopathological Society. ... online now at APSnet.org/meet . , The Preliminary ... to be held August 1-5, 2015 in Pasadena, California, ... Trips, Workshops, and committee meetings, all carefully balanced to ...
(Date:3/5/2015)... Springs, FL (PRWEB) March 05, 2015 ... Damm for the position of Vice President of Managed ... managed care relationships for one of the nation’s leading ... brings more than 15 years of specialty pharmacy and ... Damm worked with Raptor Pharmaceuticals, Vertex Pharmaceuticals, and Pfizer. ...
Breaking Biology Technology:HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 2HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 3HX360 Announces Sixteen Innovation Challenge Semi-finalists Competing To Deliver Solutions That Improve The Patient Experience 4LifeCell Dx Offers New Option to Veterans with Infertility 2LifeCell Dx Offers New Option to Veterans with Infertility 3American Phytopathological Society Announces Annual Meeting Daily Schedule 2BioPlus Specialty Pharmacy Announces Hiring of New Vice President of Managed Care: Jamie Damm 2
... LONDON, May 25, 2011 The Marken Board of Directors ... MBA as Chief Executive Officer. Mr. Wheeler succeeds Gerard Barba, ... Directors. Marken,s Board and executive management team have ... his in depth of experience in the life science industry ...
... 25, 2011 /PRNewswire/ -- Vermillion, Inc. ... announced that the United States Patent and Trademark Office (USPTO) ... "Saposin D and Fam3C are Biomarkers for Alzheimer,s Disease."  The ... well as combinations that include these biomarkers. "This ...
... PARSIPPANY, N.J. and ATHENS, Greece, May 25, 2011 ... ) and Specifar Pharmaceuticals S.A. today jointly announced ... pharmaceutical developer, manufacturer and marketer for EUR 400 ... consideration. As a result of the acquisition, Watson ...
Cached Biology Technology:Wes Wheeler Appointed as CEO by Marken's Board of Directors 2Vermillion Announces Notice of Allowance for Alzheimer Patent 2Vermillion Announces Notice of Allowance for Alzheimer Patent 3Watson Acquires Specifar Pharmaceuticals 2Watson Acquires Specifar Pharmaceuticals 3Watson Acquires Specifar Pharmaceuticals 4Watson Acquires Specifar Pharmaceuticals 5Watson Acquires Specifar Pharmaceuticals 6
Anti-MMP-19 (RASI), carboxy terminal region; rabbit host...
Rabbit anti MMP-13, Hinge Region MMP-13 Hinge Region...
Rabbit polyclonal to ATF4 (phospho S245) ( Abpromise for all tested applications). Antigen: Synthetic phosphopeptide derived from human ATF4 around the phosphorylation site of Serine 245. En...
Evolutionarily conserved signaling intermediate in Toll pathway...
Biology Products: