Navigation Links
Pathway for membrane building blocks
Date:1/30/2013

The lipid molecules of membranes, also known as phospholipids, are composed of two elements: A hydrophilic head and two long-chain fatty acids. The molecules form a bilayer in the membrane, with all of the heads pointing outwards and the fatty acid chains hanging in a zip-like interlay position.

Biomembranes are constantly reorganized or renewed, for example whenever cells divide. The cell is constantly creating new phospholipids that have to align themselves which they do in both layers of the biomembrane. However, cells only produce phospholipids on one side of the biomembrane. From there, they need to be transported to the other half of the bilayer.

A helping hand through the membrane

The problem is that the hydrophilic and lipophilic parts of the molecule repel each other. "The molecules can anchor themselves in one of the two membrane layers with their lipophilic tail," explains Prof. Dieter Langosch of the TUM Chair of Biopolymer Chemistry. "Translocation to the second layer is not possible because the hydrophilic heads cannot pass through the lipophilic fatty acid chains."

The key to establishing order in the membranes lies in enzymes that transport the molecules to their correct location in the "second layer". Scientists have been searching for such enzymes known as flippases for many years. But now Prof. Langosch and his team have made a breakthrough. They experimented with synthetic peptides, which transport phospholipids through the membrane.

A clever trick

In this process, the researchers came across an indirect transport mechanism. The peptides span both layers of the membrane and are able to bind to individual phospholipids. Prof. Langosch explains: "When the peptides bind the molecules, the surrounding membrane is briefly destabilized. The new phospholipids use this opportunity to slip through the barrier of the first lipid layer and flip to the second layer of the membrane."

The researchers now have a clear idea of how flippases work. "Our peptides stretch through the membrane like a corkscrew. If this "alpha-helix" has dynamic elements, it can bind to phospholipids," says Prof. Langosch. "This model will help us to detect the flippases."


'/>"/>

Contact: Barbara Wankerl
wankerl@zv.tum.de
49-892-892-2562
Technische Universitaet Muenchen
Source:Eurekalert  

Related biology news :

1. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
2. Researchers uncover molecular pathway through which common yeast becomes fungal pathogen
3. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
4. Study discovers genetic pathway impacting the spread of cancer cells
5. Researchers pinpoint genetic pathway of rare facial malformation in children
6. A new candidate pathway for treating visceral obesity
7. Study identifies pathway to enhance usefulness of EGFR inhibitors in lung cancer treatment
8. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
9. Fragile X and Down syndromes share signalling pathway for intellectual disability
10. New neural pathway controlling skeletal development discovered
11. Discovery of molecular pathway of Alzheimers disease reveals new drug targets
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Pathway for membrane building blocks
(Date:4/5/2017)... 2017 Today HYPR Corp. , leading ... component of the HYPR platform is officially FIDO® ... security architecture that empowers biometric authentication across Fortune 500 ... secured over 15 million users across the financial services ... home product suites and physical access represent a growing ...
(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/30/2017)... YORK , March 30, 2017 Trends, ... type (physiological and behavioral), by technology (fingerprint, AFIS, iris ... voice recognition, and others), by end use industry (government ... and immigration, financial and banking, and others), and by ... Europe , Asia Pacific , ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... ... October 12, 2017 , ... ... the pharmaceutical and biotechnology industries to improve patient outcomes and quality of life, ... in analytical testing are being attributed to new regulatory requirements for all new ...
(Date:10/11/2017)... ... ... a basic first aid supply for any work environment, but most personal eye wash can ... a dangerous substance enters both eyes? It’s one less decision, and likely quicker response time ... , “Whether its dirt and debris, or an acid or alkali, getting anything in your ...
(Date:10/11/2017)... Netherlands and LAGUNA HILLS, Calif. ... Institute of Cancer Research, London (ICR) ... MMprofiler™ with SKY92, SkylineDx,s prognostic tool to risk-stratify patients with ... known as MUK nine . The University of ... which is partly funded by Myeloma UK, and ICR will ...
(Date:10/10/2017)... DIEGO, CALIF. (PRWEB) , ... October 10, 2017 , ... ... as part of its corporate rebranding initiative announced today. The bold new look ... its reach, as the company moves into a significant growth period. , It will ...
Breaking Biology Technology: