Navigation Links
Parkinsonian worms may hold the key to identifying drugs for Parkinson's disease
Date:11/10/2011

AUSTIN, Texas Researchers at The University of Texas at Austin have devised a simple test, using dopamine-deficient worms, for identifying drugs that may help people with Parkinson's disease.

The worms are able to evaluate as many as 1,000 potential drugs a year. The researchers have received federal funding that could increase that to one million drug tests a year.

The test is based on the difficulty that these "parkinsonian" C. elegans worms have in switching from swimming to crawling when they're taken out of water.

"They can crawl fine," says Jon Pierce-Shimomura, assistant professor of neurobiology. "They go into a puddle and can swim fine. But as soon as the puddle goes away they crash. In some cases an individual will remain rigid for about a half hour."

Pierce-Shimomura led a team of researchers, including Andres Vidal-Gadea, Stephen Topper and Layla Young, to identify this "motor switching" problem. Their findings were published last month in the Proceedings of the National Academy of Science.

"We take these motor transitions for granted," says Pierce-Shimomura, "like getting up out of a chair or walking through a doorway from one surface to another. But people with Parkinson's have a terrible time with this. They freeze at the threshold. It looks like we have a very simple worm model for this now."

To identify potential therapeutics, Pierce-Shimomura begins with worms that have been mutated to be deficient in producing dopamine. It's the loss of dopamine-producing cells in the brain that causes Parkinson's disease in humans.

The dopamine-deficient worms are put through the same paces that lead to the immobility, but in the presence of a drug.

If they become immobile as they normally would when water is removed, the researchers move on to the next drug. But if somehow a drug helps the worms' brains overcome the dopamine deficiency and they transition to crawling, the lab ha
'/>"/>

Contact: Daniel Oppenheimer
oppenheimer@austin.utexas.edu
512-745-3353
University of Texas at Austin
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Floridas worm grunters collect bait worms by inadvertently imitating mole sounds
2. Deprived of a sense of smell, worms live longer
3. Key to curing obesity may lie in worms that destroy their own fat: McGill researchers
4. Ancient geologic escape hatches mistaken for tube worms
5. Parasitic worms make sex worthwhile
6. Pinhead-size worms + robot = new antibiotics
7. More than fish bait: Worms unlock secrets to new epilepsy treatments
8. Scientists find new genes for cancer, other diseases in plants, yeast and worms
9. Bone-eating worms 30 million years old
10. Brains, worms and computer chips have striking similarities
11. Body builders -- the worms that point the way to understanding tissue regeneration
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Parkinsonian worms may hold the key to identifying drugs for Parkinson's disease
(Date:7/2/2015)... , June 25, 2015 ... announced the addition of the "Natural Language ... Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) ... their offering. The key vendors occupying ... HP, IBM Corporation, Microsoft Corporation, NetBase Solutions, SAS ...
(Date:6/29/2015)... 2015 Research and Markets( ... "Latin America Biomedical Sensors Market - Growth, Trends & ... The Latin America Biomedical Sensors market is estimated at ... over the period 2014-2020 The near future ... genetic formulation of each individual. These sensors can be ...
(Date:6/24/2015)... YORK , June 24, 2015 The ... rate. The major drivers for the market include growth ... number of new drug launches. Over the years, the ... increased. Between 2001 and 2010, the FDA approved 225 ... according to WIPO, Europe accounted ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2Latin America Biomedical Sensors Market Report 2015-2020 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... BOZEMAN, Mont. -- Research by a Montana State ... paleontologists is upending more than 100 years of thought ... Since the late 1800s, scientists have believed that Triceratops ... had a three-horned skull with a rather short frill, ...
... Rice University scientists have found the "ultimate" solvent for ... brings the creation of a highly conductive quantum nanowire ... of bundling, making them less useful than when they,re ... Pasquali, a professor in chemical and biomolecular engineering and ...
... of care comprised of surgery, radiation and chemotherapy ... number of biological responses that may actually feed the energy ... writing in the journal Lancet Oncology . The ... of about a year from diagnosis. Just three percent of ...
Cached Biology News:Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages 2Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages 3Montana State researchers say Triceratops, Torsaurus were same dinosaur at different stages 4Nanotubes pass acid test 2Nanotubes pass acid test 3Does the existing standard of care supply energy sources to brain tumor cells? 2
(Date:7/29/2015)... CA. (PRWEB) , ... July 29, 2015 , ... ... with PRC Clinical, a Silicon Valley-based CRO specializing in Clinical Trial ... services, and patient recruitment services. The core expertise of PRC Clinical is focused ...
(Date:7/29/2015)... , ... July 29, 2015 , ... Nearly everyone has ... diseases. Yet few people realize that a rich source of these cells is teeth—baby ... and teeth that need to be pulled to make room for braces. These ...
(Date:7/28/2015)... July 28, 2015 People with a common ... achieved significant and sometimes profound improvements in their hearing ... according to a new multicenter study led by specialists ... study, described online ahead of print in the journal The ... private clinics in the United States ...
(Date:7/28/2015)... ... July 28, 2015 , ... VetStem Biopharma will be ... cell credentialing course to local area veterinarians. , The tour and course will be ... at no charge) at VetStem’s Poway facility. Staff members are welcome to attend with ...
Breaking Biology Technology:CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 2CSSi LifeSciences And PRC Clinical Join Forces To Offer Extended Clinical Trial Services 3Advanced Oral and Maxillofacial Surgery (AOMS) in Elmhurst, IL Partners with Provia Labs to make Store-A-Tooth™ Dental Stem Cell Banking Available to their Patients 2Hybrid Cochlear Implants For Common Form Of Hearing Loss May Benefit Millions 2Hybrid Cochlear Implants For Common Form Of Hearing Loss May Benefit Millions 3VetStem Biopharma weekly veterinary continuing education classes and GMP manufacturing facility tour 2
... clearance for two new brain imaging applications, a local ... products to healthcare providers. , ,Approval from the ... Radiologic Health in June allowed Kyron Clinical ... line of brain mapping solutions based on functional and ...
... , Wis. - Platypus Technologies recently ... new line of products and court strategic partners - ... and nanotechnology company is prepared to expand its product ... used by researchers, and management is in discussions with ...
... Wis. - Local angel investor network Silicon ... Clearent, LLC , which is developing a next-generation credit ... , ,It's not unusual for Wisconsin-based investors to look ... of Silicon Pastures, said this investment opportunity arrived at ...
Cached Biology Technology:Kyron wins FDA approval for brain imaging technology 2Platypus ready to unveil new commercial lines 2Platypus ready to unveil new commercial lines 3Platypus ready to unveil new commercial lines 4