Navigation Links
Ovarian cancer metastases influenced by factors in target tissues
Date:7/17/2013

terine, and mesenteric fat). They found that different ovarian cancer cell lines (mouse derived ID8, and human derived SKOV3ip.1, HeyA8, and CaOV3) specifically colonize omental and splenoportal fat, forming large lesions of cancer cells within milky spots. In contrast, ovarian cancer cells were rarely detected in abdominal fat that lacks milky spots.

The rapid localization of ovarian cancer cells to milky spots indicated that omental tissue secretes a factor, or factors that attract the cancer cells to these structures. Experiments showed that milky-spot-containing tissues in particular can condition cell growth medium to stimulate the migration of cancer cells. This study found that cell medium conditioned by omenta and splenoportal fat caused a 95-fold increase in cell migration, compared to controls. This study also examined mice with specific immunodeficiencies to show that ovarian cancer cell colonization of milky spots is not affected by deficiency or absence of T cells, B cells, and/or NK cells.

The authors also found an inverse relationship between ovarian cancer cell growth and depletion of adipocytes. "These data are consistent with previous reports from other investigators that indicate cancer cells use lipids stored in adipocytes as an energy source for their continued growth," says Dr. Rinker-Schaeffer. "Certain tumor cells (the 'seed') have a proclivity for specific organ microenvironments (the 'soil')," adds Dr. Rinker-Schaeffer. "Pioneers of metastasis research appreciated that the unique tissue architecture, physiology, and function of the target organ are essential to understanding metastatic organ specificity. With this in mind, we hope that our findings and discussion of how they fit into the big picture of omental colonization will facilitate studies that continue to improve our understanding of this process."

In 2012, ovarian cancer was diagnosed in almost 23,000 American women and 16,000 died from the disease.
'/>"/>

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
2. Life span of ovarian grafts longer than expected
3. Early menopause: A genetic mouse model of human primary ovarian insufficiency
4. Ovarian tumor, with teeth and a bone fragment inside, found in a Roman-age skeleton
5. Identified as responsible for breast and ovarian hereditary cancer 3 mutations at BRCA1 gene
6. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
7. Adverse effects of phthalates on ovarian response to IVF
8. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
9. Embryonic development protein active in cancer growth
10. BRG1 mutations confer resistance to hormones in lung cancer
11. Genetic variation in East Asians found to explain resistance to cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/19/2015)... , Aug. 19, 2015  VOXX International ... it has entered into a Definitive Agreement to ... of iris authentication market leader EyeLock through an ... will have a controlling interest in the acquiring ... to completion of due diligence.  Expanding on its ...
(Date:8/17/2015)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the ... mobile commerce market and creator of the Wocket® smart ... The new marketing campaign is being spearheaded by an ... ( http://amplitudemarketing.com/ ) and TPMG ( http://tmpg.com/ ). ... driven marketing and brand awareness and has a client ...
(Date:8/12/2015)...  New research unveiled at Black Hat 2015 ... steal users, fingerprints. Information released today by HYPR ... on mobile devices, making the security of this ... mobile devices, HYPR Corp. recently released a biometric ... with strong cryptographic security. More information on this ...
Breaking Biology News(10 mins):VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 2VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 3VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 4VOXX International Corporation Signs Definitive Agreement To Acquire The Assets And A Controlling Interest Of Biometric Leader EyeLock 5NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 2HYPR Corp. Addresses Android Vulnerability That Exposes Ecosystem-wide Biometric Security Challenges 3
... (SACRAMENTO, Calif.) Smokers who don,t quit before ... neck cancers fair significantly worse than those who do, ... Allen Chen, an assistant professor in the Department ... found that head- and neck-cancer patients who continue to ...
... This press release is available in French . ... most deadly parasitic diseases in the world. It affects more than ... it kills 50 000 people each year. A reliable and rapid ... now, this has been next to impossible. Dr. Momar Ndao and ...
... America needs more vitamin D. It,s one more reason to ... at the Experimental Biology conference in Anaheim, California. Milk is ... supplying nearly half of all of the much-needed vitamin D. ... what more than 16,000 Americans ages two and older eat, ...
Cached Biology News:Smoking during radiation therapy for head and neck cancers linked to poorer outcomes 2Smoking during radiation therapy for head and neck cancers linked to poorer outcomes 3Major breakthrough in the diagnosis of parasitic diseases 2
(Date:8/31/2015)... ... August 31, 2015 , ... ... of its properties such as low carbon footprints and compostability. These properties can ... petroleum based plastics. On the basis of applications, the market for biodegradable plastics ...
(Date:8/31/2015)... Aug. 31, 2015 Research and Markets ( ... "Mexico Biomedical Sensors Market - Growth, Trends & Forecasts ... The Mexico Biomedical Sensors market is estimated at ... over the period 2014-2020 The near future ... genetic formulation of each individual. These sensors can be ...
(Date:8/31/2015)... , Aug. 31, 2015  For people with ... brighten their day. The biotechnology company, located in the ... one of the best potential therapies yet for people ... entitled, " Correction of Down syndrome and Edwards syndrome ... journal DNA Research . Elixirgen plans to develop ...
(Date:8/31/2015)... , Aug. 31, 2015  US-Australian drug ... NVGN ) today confirmed its comprehensive scientific review ... technology platforms in areas of unmet patient need. ... the remaining preclinical projects prior to entering into ... compounds. Acting Chief Executive Officer, ...
Breaking Biology Technology:Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 2Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 3Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 4Biodegradable Plastics Market Growing at 10.8% CAGR to 2020 5Mexico Biomedical Sensors Market Report 2015-2020 2New Down syndrome therapy discovered 2Novogen Announces The Outcome Of A Comprehensive Science Review 2Novogen Announces The Outcome Of A Comprehensive Science Review 3Novogen Announces The Outcome Of A Comprehensive Science Review 4Novogen Announces The Outcome Of A Comprehensive Science Review 5Novogen Announces The Outcome Of A Comprehensive Science Review 6
... A new test developed by Japanese scientists may revolutionize ... a research report published online in The FASEB ... proteins in the spinal fluid known to be one ... impairment in Alzheimer,s patients: high molecular weight A-Beta oligomers. ...
... nuclear reactors may one day become a reality ... National Laboratory scientists. In a paper appearing ... Alamos researchers report a surprising mechanism that allows ... damage. Nanocrystalline materials are those created from nanosized ...
... ... by the Small Business Commerce Association (SBCA). The SBCA 2009 Award Program recognizes the top ... , ... 2010 -- BioSoteria, Inc ., a drug safety services and education firm, announced today ...
Cached Biology Technology:New test takes guesswork out of diagnosing early stage Alzheimer's disease 2Safer nuclear reactors could result from Los Alamos research 2Safer nuclear reactors could result from Los Alamos research 3Drug Safety Firm BioSoteria Receives 2009 Best of Business Award 2