Navigation Links
Ovarian cancer metastases influenced by factors in target tissues
Date:7/17/2013

terine, and mesenteric fat). They found that different ovarian cancer cell lines (mouse derived ID8, and human derived SKOV3ip.1, HeyA8, and CaOV3) specifically colonize omental and splenoportal fat, forming large lesions of cancer cells within milky spots. In contrast, ovarian cancer cells were rarely detected in abdominal fat that lacks milky spots.

The rapid localization of ovarian cancer cells to milky spots indicated that omental tissue secretes a factor, or factors that attract the cancer cells to these structures. Experiments showed that milky-spot-containing tissues in particular can condition cell growth medium to stimulate the migration of cancer cells. This study found that cell medium conditioned by omenta and splenoportal fat caused a 95-fold increase in cell migration, compared to controls. This study also examined mice with specific immunodeficiencies to show that ovarian cancer cell colonization of milky spots is not affected by deficiency or absence of T cells, B cells, and/or NK cells.

The authors also found an inverse relationship between ovarian cancer cell growth and depletion of adipocytes. "These data are consistent with previous reports from other investigators that indicate cancer cells use lipids stored in adipocytes as an energy source for their continued growth," says Dr. Rinker-Schaeffer. "Certain tumor cells (the 'seed') have a proclivity for specific organ microenvironments (the 'soil')," adds Dr. Rinker-Schaeffer. "Pioneers of metastasis research appreciated that the unique tissue architecture, physiology, and function of the target organ are essential to understanding metastatic organ specificity. With this in mind, we hope that our findings and discussion of how they fit into the big picture of omental colonization will facilitate studies that continue to improve our understanding of this process."

In 2012, ovarian cancer was diagnosed in almost 23,000 American women and 16,000 died from the disease.
'/>"/>

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
2. Life span of ovarian grafts longer than expected
3. Early menopause: A genetic mouse model of human primary ovarian insufficiency
4. Ovarian tumor, with teeth and a bone fragment inside, found in a Roman-age skeleton
5. Identified as responsible for breast and ovarian hereditary cancer 3 mutations at BRCA1 gene
6. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
7. Adverse effects of phthalates on ovarian response to IVF
8. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
9. Embryonic development protein active in cancer growth
10. BRG1 mutations confer resistance to hormones in lung cancer
11. Genetic variation in East Asians found to explain resistance to cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... research into the potato genes that best adapt to ... in rainfall and increased extremes of hot and cold ... in order to create new potato varieties that will ... seeking to find out how the current potato varieties ... higher and lower temperatures. , This research is part ...
(Date:7/24/2014)... in which life arose have been maintained in our cells ... , Research published today in the Journal of Biological ... likely also in animals still perform ancient reactions thought to ... four billion years ago. , The primordial soup theory suggests ... result of the combination of metals, gases from the atmosphere ...
(Date:7/24/2014)... international team of researchers led by the University of ... marine conservation in the Western Indian Ocean. , ... , point to a revolution in the management of ... more than 11,000 km in the region ... (MPAs) are zones of the seas and coasts designed ...
Breaking Biology News(10 mins):Neiker-Tecnalia is researching the potato genes that best adapt to climate change 2Western Indian Ocean communities play vital role in conservation 2
... Small migratory birds, like the garden warbler, must make ... have crossed extensive ecological barriers, such as deserts or oceans, ... from the Max Planck Institute for Ornithology in Seewiesen and ... stopovers made by garden warblers on an island off the ...
... alike face critical choices as they reproduce: to ... small, poorly-provisioned ones. Different species make strikingly different ... forms: Darwin,s "endless forms most beautiful. ... Tropical Research Institute argues that these diverse strategies ...
... manipulation of the Earth,s climate to slow or reverse ... climate change discussion. But before effective action can be ... understood. Two Northwestern University studies, both published online ... and related -- clues as to what drove large-scale ...
Cached Biology News:Chubby birds get there faster 2Stress and trade-offs explain life's diversity: New Smithsonian model 2The carbon cycle before humans 2The carbon cycle before humans 3
(Date:7/24/2014)... 24, 2014 Three companies from the ... Livestrong’s Big C Competition. Out of 700 competition entrants, ... to the semi-final round. In this round twenty teams ... program, complete with mentoring from thought-leaders and medical entrepreneurs ... of the angelMD commitment to the Livestrong vision around ...
(Date:7/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Sulphate basic information, including its definition, classification, ... This research covers the international market analysis, including ... analysis covering macroeconomic environment & economic situation analysis, ...
(Date:7/24/2014)... Mich. , July 24, 2014  Neogen Corporation ... that future forecasts of its potential revenue from new ... call to investors and analysts on July 22, 2014, ... by analysts regarding this research. "It was ... questions about the potential of a new type of ...
(Date:7/24/2014)... July 24, 2014 WIRB-Copernicus Group ® ... and ethical review services for clinical research, announced ... a division of Richmond, VA ... biosafety and biosecurity consulting firm in ... WCG,s biosafety division – WCG Biosafety™ – will ...
Breaking Biology Technology:3 angelMD Startups Make Livestrong Big C Semi-finals 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4Neogen comments on SenesTech 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3
... eICU(R) Programs Close Critical Care Coverage Gap, WASHINGTON, ... at the forefront of the recent political campaigns is ... of the country. The government,recently took steps to alleviate ... Iowa residents -- a problem that is being exacerbated ...
... NVN) today announced financial results for the third,quarter and ... product developments and corporate milestones., ... corporate highlights:, o On October ... a corporate restructuring ...
... Nov. 11 /Xinhua-PRNewswire-FirstCall/ -- China,Clean Energy Inc. (OTC ... announced that, as of November 10, 2008 it ... to resume biodiesel production at its,existing plant in ... prices, thus,allowing the Company to enjoy sufficient margins ...
Cached Biology Technology:USDA Awards $1.5 Million to Expand Access to High-Quality Critical Care in Rural Communities 2USDA Awards $1.5 Million to Expand Access to High-Quality Critical Care in Rural Communities 3Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results and Recent Corporate Highlights 2Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results and Recent Corporate Highlights 3Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results and Recent Corporate Highlights 4Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results and Recent Corporate Highlights 5Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results and Recent Corporate Highlights 6Nventa Biopharmaceuticals Announces Third Quarter 2008 Financial Results and Recent Corporate Highlights 7China Clean Energy Resumes Biodiesel Production After Temporary Halt 2China Clean Energy Resumes Biodiesel Production After Temporary Halt 3
... MasterAmp™ Taq DNA Polymerase is a ... aquaticus. Having optimal activity at temperatures ... thermostable enzyme used for PCR and ... purpose. The enzyme has an intrinsic ...
... 4100 high pressure dual piston pump and the ... and utra low drift. The WaveQuest ... detection and provides superior stability. Hence ... and for monitoring to the highest of sensitivities. ...
Rabbit anti Xanthine Oxidase Xanthine Oxidase, Bovine Buttermilk...
... This CLS number ... number, created to easily ... If showing no availability ... the old Sigma-Aldrich number ...
Biology Products: