Navigation Links
Ovarian cancer metastases influenced by factors in target tissues
Date:7/17/2013

Philadelphia, PA, July 18, 2013 Cancer researchers have wondered why ovarian cancer cells are so attracted to the abdominal cavity, especially the omentum, with the hope that such an understanding could lead to better disease management or even prevention. Results from a series of experiments suggest a two-step model of omental colonization in which i) cancer cells are attracted to and lodge within immune cell-containing structures known as milky spots, and ii) fat storage cells (adipocytes) fuel cancer cell growth and spread. This study is scheduled for publication in the August 2013 issue of The American Journal of Pathology.

The omentum is a large fatty structure that drapes off the stomach and blankets the peritoneal organs. Omental fat is composed of adipocytes, blood vessels, immune cells, and other connective tissue and contains unusual immune cell-containing structures known as milky spots, which play a key role in many of its protective functions. In previous research, investigators focused either on the milky spots or the adipocytes as key to attracting metastatic ovarian cancer cells. The results of the current experiments show that "although there are clear strengths to both of these models, neither address the intimate and dynamic interaction among milky spots, surrounding adipocytes, and other components of omental tissues. We propose an alternative, more fully integrated model," says Carrie Rinker-Schaeffer, PhD, a professor in the Departments of Surgery (Section of Urology) and Obstetrics and Gynecology at The University of Chicago.

In the first experiment, researchers investigated whether abdominal fat tissue that contains milky spots is a more attractive target for cancer cells than abdominal fat that does not contain milky spots. This study took advantage of the fact that mice have a second source of milky spot-containing abdominal fat (splenoportal fat) as well as fat that is devoid of milky spots (the gonadal, u
'/>"/>

Contact: Eileen Leahy
ajpmedia@elsevier.com
732-238-3628
Elsevier Health Sciences
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers identify genes that may help in ovarian cancer diagnosis and prognosis
2. Life span of ovarian grafts longer than expected
3. Early menopause: A genetic mouse model of human primary ovarian insufficiency
4. Ovarian tumor, with teeth and a bone fragment inside, found in a Roman-age skeleton
5. Identified as responsible for breast and ovarian hereditary cancer 3 mutations at BRCA1 gene
6. An article in Cell reveals a new resistance mechanism to chemotherapy in breast and ovarian cancer
7. Adverse effects of phthalates on ovarian response to IVF
8. Tortoise and the hare: New drug stops rushing cancer cells, slow and steady healthy cells unharmed
9. Embryonic development protein active in cancer growth
10. BRG1 mutations confer resistance to hormones in lung cancer
11. Genetic variation in East Asians found to explain resistance to cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2015)... YORK , March 31, 2015  Elephant Talk ... "Company"), a global provider of Software Defined Network Architecture ... today announced total revenue of approximately $20.4 million for ... a restated $19.5 million for the year ended December ... calendar 2014, the Company had completed its multi-year transition ...
(Date:3/26/2015)... TORONTO , March 26, 2015 ... premier family, social, recreation and athletic club, today announced ... designed to allow freedom of movement for members and ... "Following a comprehensive process, we selected FST,s IMID ... sophistication and convenience for our members and staff, in ...
(Date:3/24/2015)... 24, 2015   NexID Biometrics LLC, whose ... needs, today announced the beginning of shipments of version ... The company, based in Potsdam, N.Y. ... Connect:ID Expo, which began here today at the Walter ... 2.0 of its SDK boosts the accuracy rate range ...
Breaking Biology News(10 mins):Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 2Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 3Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 4Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 5Elephant Talk Reports 2014 Fourth Quarter and Year End Financial Results 6Granite Club First Private Club in North America to Implement FST Biometrics Secure Access Solution, as Part of Multi-million Dollar Expansion 2NexID Begins Shipments Of Version 2.0 Fake-Finger-Detection Solution 2
... Scientists at IRB Barcelona have discovered that some brain ... use the genetic programme of germline cells to grow. ... brains. This finding demonstrates that these genes are crucial for ... is published today in the prestigious journal Science . ...
... study was carried out to examine the extent ... or insulin resistance in primary cultures of human ... cytokine elevated in the plasma and adipose tissue ... adipocytes were pretreated with quercetin and trans-RSV followed ...
... have succeeded in plugging a metal atom into a ... could be a key in opening up new production ... of organic compounds, which in turn might have implications ... is the first to determine the precise structure of ...
Cached Biology News:Some brain tumors mimic the genetic program of germline cells 2Study on effects of resveratrol and quercetin on inflammation and insulin resistance 2Milestone: A methane-metal marriage 2Milestone: A methane-metal marriage 3Milestone: A methane-metal marriage 4
(Date:4/17/2015)... MIAMI (PRWEB) April 17, 2015 ... attend the GTCbio Stem Cell Summit 2015 April 27 ... present the latest developments in all areas of stem ... business of stem cells and regenerative medicine. , ... clinical trials, as well as translational research in stem ...
(Date:4/16/2015)... Bythewood, South Carolina (PRWEB) April 17, 2015 ... solutions and steam system services, released their newly ... 2015. The customer facing website effectively promotes ... proposition. , All the information that a ... training, steam system services, company capabilities, industries serviced, ...
(Date:4/16/2015)... South San Francisco, CA (PRWEB) April 16, 2015 ... it is scheduled to report first quarter results on ... Following the announcement, Cytokinetics’ senior management will host a ... operational and financial results and the company’s outlook for ... webcast and can be accessed from the homepage and ...
(Date:4/16/2015)... Associates IRB, Inc., the industry-leading central IRB in customer ... Laboratory Drive in the heart of Research ... house review board and service staff, which will be ... service to clients. CBRE | ... while Capital Associates Management, LLC represented the landlord.   ...
Breaking Biology Technology:Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 2Global Stem Cells Group To Join GTCbio Stem Cell and Regenerative Medicine Summit in Boston, April 27-29, 2015 3Spirax Sarco website has a new look 2Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3Schulman IRB to Open Office in Research Triangle Park, N.C. 2
... managed, with the help of an advanced X-ray flash, to ... that has been recognised by the journal Science . ... home to one of the world,s most advanced particle accelerators, ... and study life,s tiniest components: atoms, molecules and proteins. ...
... PLYMOUTH MEETING, Pa. , May 10 /PRNewswire-Asia-FirstCall/ -- ... announced,financial results for the first quarter ended March 31, 2010 . ... ... was a,quarter of successful management transition at Sunstone. We replaced senior,managers including ...
... Fla. , May 10 Dyadic International, Inc. ... today that its President and Chief Executive Officer, Mark ... Renshaw 6th Annual Global Healthcare Conference in London, England ... 11:05 a.m. local time ( 6:05 a.m. EDT ). ...
Cached Biology Technology:BMP Sunstone Reports First Quarter 2010 Financial Results 2BMP Sunstone Reports First Quarter 2010 Financial Results 3BMP Sunstone Reports First Quarter 2010 Financial Results 4BMP Sunstone Reports First Quarter 2010 Financial Results 5BMP Sunstone Reports First Quarter 2010 Financial Results 6BMP Sunstone Reports First Quarter 2010 Financial Results 7BMP Sunstone Reports First Quarter 2010 Financial Results 8BMP Sunstone Reports First Quarter 2010 Financial Results 9BMP Sunstone Reports First Quarter 2010 Financial Results 10BMP Sunstone Reports First Quarter 2010 Financial Results 11BMP Sunstone Reports First Quarter 2010 Financial Results 12Dyadic International to Present at Rodman & Renshaw 6th Annual Global Healthcare Conference 2
Request Info...
Prepared in distilled water....
... egg white. The extinction coefficient , E(1%) ... mM phosphate-buffered saline, pH 7.4, ... and 50% glycerol. Avidin (from egg white) is ... by molecular sieving and is ...
NM522 contains an F episome, which is required for production of ssDNA and for blue/white color selection. To maintain the F, NM522 should be grown on minimal (M-9) medium....
Biology Products: