Navigation Links
Osteoporosis drug stops growth of breast cancer cells, even in resistant tumors
Date:6/15/2013

use you are removing the target," said lead author Suzanne Wardell, PhD, a research scientist working in McDonnell's lab.

Many investigators had assumed that once breast cancer cells developed resistance to tamoxifen, they would be resistant to all drugs that target the estrogen receptor, McDonnell explained.

"We discovered that the estrogen receptor is still a good target, even after it resistance to tamoxifen has developed," he said.

The investigators tested a variety of breast cancer cell types, including tamoxifen-sensitive cells that are resistant to the drug lapatinib, another targeted therapy that is used to treat patients with advanced breast cancer whose tumors contain the mutant HER2 gene. These cells had previously been shown to reactivate estrogen signaling in order to acquire drug resistance. In this cell type, bazedoxifene also potently inhibited cell growth.

Paradoxically, in bone tissue, bazedoxifene mimics the action of estrogen, helping protect it from destruction. Because bazedoxifene has already undergone safety and efficacy studies as a treatment for osteoporosis, it may be a viable near-term option for patients with advanced breast cancer whose tumors have become resistant to other treatment options, Wardell reported. In clinical trials, the most often reported side effect was hot flashes in the bazedoxifene treatment groups.


'/>"/>

Contact: Rachel Harrison
rachel.harrison@duke.edu
919-419-5069
Duke University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. IOF Worldwide Conference of Osteoporosis Patient Societies opens in Helsinki
2. Program announced for the 4th Asia-Pacific Osteoporosis Meeting in Hong Kong
3. Worlds largest meeting dedicated to osteoporosis and osteoarthritis opens in Rome
4. European Guidance for the diagnosis & management of osteoporosis in postmenopausal women
5. Less than 1 month to start of European Congress on Osteoporosis & Osteoarthritis in Rome
6. 4th Asia-Pacific Osteoporosis Meeting to be led by regions leading bone experts
7. European Congress on Osteoporosis and Osteoarthritis
8. Summit of osteoporosis experts from CIS countries issue 5-point call for action
9. IOF Asia-Pacific Meeting presents new research and advances in osteoporosis management
10. Launch of the EU large-scale integrating project BlueGenics to combat osteoporosis
11. Register now for the key osteoporosis meeting in the Asia-Pacific region
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... California , December 9, 2014 ... with ITN,s BCARD Platform   ... cloud-based enterprise meeting scheduling solutions for business-to-business (B2B) ... the world leader in mobile near-field communication (NFC), ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , ...
(Date:12/3/2014)... 2014 As part of our commitment to ... pleased to announce the release of a new reader ... the workforce data that they need. The ... by existing readers. Many such devices have serious shortcomings ... technology. Older models force users to navigate numerous complicated ...
(Date:11/21/2014)...   Atmel® Corporation (NASDAQ: ATML ... technology solutions, today launched the industry,s first family of ... V cc range from 1.7V to 5.5V. The ... 2 C bus communication speeds, and are available with ... ideal for consumer, industrial, computer, and medical applications. ...
Breaking Biology News(10 mins):Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Inception Technologies to Release New Biometric Reader 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 2Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 3Atmel Launches Industry's First Wide-V(cc) Low-Power Temperature Sensor Family 4
... Cancer Discovery , a journal of the American Association ... be on the horizon for neuroendocrine prostate cancers, the ... M.D., professor of pathology and laboratory medicine at Weill ... of men with prostate cancer present with neuroendocrine prostate ...
... of alfalfa and a long-established model for the study of legume ... around 94 per cent of its genes. The research ... subfamily of legumes, which includes peas, soybean and all legumes grown ... work with bacteria to provide them with nitrogen from the air. ...
... and their declines far exceed those of other animal ... as threatened according to the Red List of the ... factors threaten global amphibian diversity but the spatial distribution ... A new study published in Nature with ...
Cached Biology News:Genome sequence sheds new light on how plants evolved nitrogen-fixing symbioses 2Predicting future threats for global amphibian biodiversity 2
(Date:12/19/2014)... 2014 Research and Markets ( ... "Technology Innovations in Smart Fabrics (Technical Insights)" ... http://photos.prnewswire.com/prnh/20130307/600769 The Research ... a detailed assessment on technological advancements and market ... 1. The Smart Fabrics market is ...
(Date:12/19/2014)... 2014 Ed Bilsky, Ph.D., vice president ... for Excellence in the Neurosciences (CEN), and professor of ... selected as a member of the prestigious Dana Alliance ... from Maine to receive this honor. , The ... by the Dana Foundation. Its mission is to ...
(Date:12/19/2014)... 2014 The empty capsules market ... ageing population and technological innovations in the empty ... are catalysing the growth of the empty capsules ... , Scope of Report , The report ... new entrants/smaller firms to gauge the pulse of ...
(Date:12/19/2014)... --  ISN has released its third annual U.S. ... publication series. With data aggregated from over eight billion ... its online contractor management platform, ISNetworld, this three-part series ... statistics. The Contractor Performance ... available in two industry specific volumes: Oil & ...
Breaking Biology Technology:Technology Innovations in Smart Fabrics (Technical Insights) 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 2UNE's Ed Bilsky Named Member of Dana Alliance for Brain Initiatives 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 2Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 3Empty Capsules Market Hit to Reach $1,820 Million by 2019 - New Research Report by MarketsandMarkets 4ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 2ISN Releases Third Edition of US Contractor Health & Safety Performance Indicators Publication Series 3
... Inc. (Nasdaq: CDXS ) today announced financial ... 31, 2010.   Full Year 2010 ... by a 77% increase in sales of pharmaceutical products, ... 2010, and increases in collaborative R&D and government grants. ...
... Caliper Life Sciences, Inc. (Nasdaq: CALP ) ... for Human Genomics (HIHG) at the University of Miami. As ... develop automated protocols for exome capture and library preparation workflows. ... released high sensitivity assay for Caliper,s LabChip® GX platform. ...
... 2011) -- Research by a Barrow Neurological Institute scientist on ... its role in pain is the cover story in the ... The research was conducted by an international team led by ... (FeverLab), at Barrow, which is a part of St. Joseph,s ...
Cached Biology Technology:Codexis Reports Fourth Quarter and Full Year 2010 Results 2Codexis Reports Fourth Quarter and Full Year 2010 Results 3Codexis Reports Fourth Quarter and Full Year 2010 Results 4Codexis Reports Fourth Quarter and Full Year 2010 Results 5Codexis Reports Fourth Quarter and Full Year 2010 Results 6Codexis Reports Fourth Quarter and Full Year 2010 Results 7Codexis Reports Fourth Quarter and Full Year 2010 Results 8Caliper Life Sciences Collaborates with University of Miami to Automate Next Generation Sequencing Workflows 2Barrow TRPV1 research highlighted in Journal of Neuroscience 2
... The Arabidopsis 2 Oligo Microarray Kit (V2), ... growth stages, and stress response. Each microarray contains ... of The Institute for Genomic Research (TIGR) and ... contains 5 standard 1 x 3? glass ...
... Successful biomarker discovery projects require screening ... to distinguish clinically relevant data from ... Data Manager is now available to ... tracking and data flood inherent to ...
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: reusable ...
... ,Product Information , ... high quality, general purpose shaker with economical analog ... models in the line, the Orbit LS features ... Electronic controls are utilized for setting speed and ...
Biology Products: