Overall, 97 percent of infants in all treatment groups achieved the secondary outcome of 50 nmol/L or greater of plasma 25(OH)D by 3 months of age, with no differences among groups. This concentration was sustained in 98 percent of infants at 12 months.
Bone mineral concentration increased over time for lumbar spine, femur, and whole body but did not differ by group.
"Our primary objective was to establish a vitamin D dosage that would support a plasma concentration of 25(OH)D of 75 nmol/L or greater in 97.5 percent of infants at 3 months of age. Only the 1,600-IU/d dosage of vitamin D met this criterion; however, this dosage was discontinued because most infants in that group developed elevated plasma 25(OH)D concentrations that have been associated with hypercalcemia [higher-than-normal level of calcium in the blood]," the authors write. "Thus, the primary outcome was not achieved at 3 months, when plasma 25(OH)D concentrations were highest; all dosages failed except the highest dosage, which appears to be too high."
"Additional studies are required before conclusions can be made regarding higher targets or the needs of high-risk groups."
(JAMA. 2013;309(17):1785-1792; Available pre-embargo to the media at http://media.jamanetwork.com)
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Editorial: Targeting Dietary Vitamin D Intakes and Plasma 25-Hydroxyvitamin D in Healthy Infants
Steven A. Abrams, M.D., of the Baylor College of Medicine, Houston, comments on the fin
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