In a comparison of the effect of different dosages of vitamin D supplementation in breastfed infants, no dosage raised and maintained plasma concentrations within a range recommended by some pediatric societies. However, all dosages raised and maintained plasma concentrations within a lower range recommended by the Institute of Medicine, according to a study in the May 1 issue of JAMA, a theme issue on child health.
Hope Weiler, R.D., Ph.D., of McGill University, Montreal, presented the findings of the study at a JAMA media briefing.
"Vitamin D is important during periods of rapid bone mineral accrual. Nursing infants are susceptible to vitamin D deficiency because vitamin D in breast milk is limited," according to background information in the article. "A supplement of 400 IU of vitamin D per day is thought to support plasma 25-hydroxyvitamin D (25[OH]D) concentrations between 40 and 50 nmol/L; some advocate 75 to 150 nmol/L for bone health. the lack of well-defined recommendations supports the need for dose-response studies."
Dr. Weiler and colleagues conducted a study to investigate the efficacy of different dosages of oral vitamin D in supporting 25(OH)D concentrations in infants. The randomized clinical trial, which included 132 one-month-old healthy, term, breastfed infants, was conducted between March 2007 and August 2010. Infants were followed up for 11 months ending August 2011 (74 percent completed the study). Participants were randomly assigned to receive oral cholecalciferol (vitamin D3) supplements of 400 IU/d (n=39), 800 IU/d (n=39), 1,200 IU/d (n=38), or 1,600 IU/d (n=16).
The researchers found that the percentage of infants achieving the primary outcome of 75 nmol/L of 25(OH)D differed at 3 months by group (for 400 IU/d, 55 percent; for 800 IU/d, 81 percent; for 1,200 IU/d, 92 percent; and for 1,600 IU/d, 100 percent). "This concentration was not sustained in 97.5 percent of infants at 12 months
|Contact: Hope Weiler|
The JAMA Network Journals