Navigation Links
Oncogenic signatures mapped in TCGA a guide for the development of personalized therapy
Date:9/27/2013

New York, September 27, 2013 -- Clinical trial design for new cancer therapies has historically been focused on the tissue of origin of a tumor, but a paper from researchers at Memorial Sloan-Kettering Cancer Center published on September 26 in Nature Genetics supports a new approach: one based on the genomic signature of a tumor rather than the tissue of origin in the body.

It is well known that the emergence of cancer is a multi-step process, but because of the efforts of The Cancer Genome Atlas (TCGA), funded by the US National Institutes of Health, and other large-scale cancer genomics efforts, for the first time this process can be viewed in exquisite molecular detail, mapping mutations and other molecular events affecting any of the 20,000 genes in a human cell.

Now, two major hypotheses have been confirmed from the genomic analysis of more than 3000 samples from 12 different tumor types: a limited number of specific genetic events appear to cause most tumor subtypes and tumors can be grouped by the oncogenic signatures they contain, no matter what the tissue of origin. That these oncogenic signatures are largely independent of the particular tissue in which the cancer arises indicates that certain drug combinations may be beneficial for select patients with different types of cancer.

"In future clinical trials, we envision that patients with a certain type of endometrial cancer, for example, may be enrolled in the same trial as patients with a subtype of colorectal cancer, and that patient selection for clinical trials can be guided by cancer genomics profiling in the clinic," stated Chris Sander, one of the principal investigators of Memorial Sloan-Kettering's Genome Data Analysis Center. "This work is intended to help in the design of such trials and the development of more-personalized cancer therapies."

The ability to reveal sets of cancer-causing events in molecular detail is based on three major technical
'/>"/>

Contact: Caitlin Hool
hoolc@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Biosignatures distinguish between tuberculosis and sarcoidosis
2. Epigenetic signatures direct the repair potential of reprogrammed cells
3. Finally mapped: The brain region that distinguishes bits from bounty
4. 100+ million mapped (and growing) records of nearly every living US species
5. Genes behind obesity mapped in large-scale study
6. Sea lamprey genome mapped with help from scientists at OU
7. Rain Man-like brains mapped at UCSF
8. Stoneflies mapped across Ohio, with implications for water quality and nature conservation
9. Signal gradients in 3-D guide stem cell behavior
10. Medboxs Marijuana Dispensing System Assists Operators in Complying with Federal Governments New Canna-Business Guidelines
11. Feline behavior experts release guidelines to improve the welfare of cats
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... , July 9, 2015  Unchained Labs ... announcing its acquisition of Avid Nano. Avid Nano ... scattering (DLS) systems.    Also today, ... fastest and easiest to use protein sizing system. ... measures a protein,s hydrodynamic size, size distribution, aggregation ...
(Date:7/8/2015)... NEW YORK , July 8, 2015 ... today announced BD & Guidepoint Mentor, ... free access to Guidepoint,s expert network services. ... developing cutting-edge technologies to improve healthcare delivery and outcomes ... manager, each start-up entrepreneur will be able to directly ...
(Date:7/7/2015)... 2015 Research and ... of the "Capacitive Fingerprint Sensors Patent Landscape" ... this date, fingerprint sensing technology is the most ... are well developed. This patent landscape focuses on ... The domain of capacitive fingerprint sensors is closely ...
Breaking Biology News(10 mins):Unchained Labs just can't get enough, acquires Avid Nano, rocks out the new pUNk! 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2
... mysterious invader washed upon the New Jersey shore. The Asian ... it found its new home to be quite agreeable. More ... has expanded its range along the Atlantic coast northward to ... expand, and wildlife biologists have found them in greater densities ...
... in <A HREF=",http://chinese.eurekalert.org/zh/emb_releases/2010-05/niom-rfl051310.php,">Chinese . , Scientists ... resilience to stress, vulnerability to depression and how ... circuit of mouse and human brains, have spurred ... the action of a key gene regulator there, ...
... its first full day with the announcement of the 2010 ... by Harold Varmus, co-chair of President Obama,s Council of Advisors ... of the announcement of the laureates by the Norwegian Academy ... discussion follows, moderated by Elizabeth Vargas of ABC News and ...
Cached Biology News:Are invasives bad? Not always, say Brown researchers 2Resilience factor low in depression, protects mice from stress 2Resilience factor low in depression, protects mice from stress 3
(Date:7/29/2015)... (Q2 2015: +14% CER / 20% of sales) led the regional performance in ... , as well as solid contributions from Korea, India ... Middle East / Africa (Q2 2015: ... , Turkey and the United Kingdom ... excluding U.S. HPV sales, on demand across all customer classes. The top seven ...
(Date:7/29/2015)... ... July 29, 2015 , ... G-CON Manufacturing, Inc., ... of their 2nd generation cell therapy POD® design. The 2nd generation portfolio not ... represents a new POD® design. , “G-CON first offered our miniPOD CT ...
(Date:7/29/2015)... July 29, 2015  Therapath Neuropathology ( www.Therapath.com ... partnerships with VA and Military Medical centers both ... Density (ENFD) and Sweat Gland Nerve Fiber Density ... ( https://therapath.com/skin ). Demonstration of ... (ENFD) on punch skin biopsy is a highly ...
(Date:7/29/2015)... , July 29, 2015 /PRNewswire/ - RepliCel Life Sciences ... regenerative medicine company, is pleased to announce that the ... (RCI-02) have been locked.  Prototypes for industrial and ... for an application for CE mark clearance to ... in 2016. (Photo: http://photos.prnewswire.com/prnh/20150729/248373 ...
Breaking Biology Technology:QIAGEN Reports Results for Second Quarter and First Half of 2015 2QIAGEN Reports Results for Second Quarter and First Half of 2015 3QIAGEN Reports Results for Second Quarter and First Half of 2015 4QIAGEN Reports Results for Second Quarter and First Half of 2015 5QIAGEN Reports Results for Second Quarter and First Half of 2015 6QIAGEN Reports Results for Second Quarter and First Half of 2015 7QIAGEN Reports Results for Second Quarter and First Half of 2015 8QIAGEN Reports Results for Second Quarter and First Half of 2015 9QIAGEN Reports Results for Second Quarter and First Half of 2015 10G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 2G-CON Manufacturing Launches Their 2nd Generation Cell Therapy Cleanroom POD® 3Neuropathology services for VA and Military health systems 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 2RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 3RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 4RepliCel Life Sciences Unveils Innovative Dermal Injector Prototype 5
... /PRNewswire-Asia/ -- Sundia MediTech, a leading,pharmaceutical R&D outsourcing service ... has been appointed Senior Vice President of Sales and,Marketing ... joining Sundia, Mr. Maher was Executive Vice President of ... CRO company in,Florida, USA. Azopharma,s CRO service scope ...
... BlueFire Ethanol Fuels, Inc. (OTC Bulletin Board: BFRE), a ... through the production of ethanol from non-food cellulosic wastes, ... biorefinery to Fulton, Mississippi. , (Logo: ... awarded a $40 million dollar grant from the U.S. ...
... ... Stemedica Cell Technologies, Inc. announced that it completed its pre-IND meeting ... (Investigative New Drug) to evaluate the safety and efficacy of Stemedica,s high ... treatment for ischemic stroke. Based on a meeting October 13, 2009 with ...
Cached Biology Technology:Sundia Appoints Charles D. Maher as Senior Vice President of Sales and Marketing 2Department of Energy Grants BlueFire Approval for Site Change 2Department of Energy Grants BlueFire Approval for Site Change 3Department of Energy Grants BlueFire Approval for Site Change 4Stemedica Completes Meeting with the FDA 2Stemedica Completes Meeting with the FDA 3
BD BioCoat BD MatrigelTM Matrix 100 mm Culture Dishes for hepatocytes, tissue-culture treated polystyrene with a uniform application of MATRIGEL Matrix....
...
... internal standard for the quantification of 5-OxoETE ... is a polyunsaturated keto acid formed by ... It stimulates cytosolic calcium levels in neutrophils ... selectively stimulates the migration and degranulation of ...
... a 10.0 kb Autographa californica (AcNPV) polyhedrin ... AcNPV polyhedrin promoter and two AcNPV p10 ... a Sma I cloning site, followed by ... inverted polyhedrin promoter has been inserted containing ...
Biology Products: