Navigation Links
Omega-3 fatty acids protect against Parkinson's, study says
Date:11/26/2007

Quebec City, November 26, 2007Omega-3 fatty acids protect the brain against Parkinsons disease, according to a study by Universit Laval researchers published in the online edition of the FASEB Journal, the journal of the Federation of American Societies for Experimental Biology. This study, supervised by Frederic Calon and Francesca Cicchetti, is the first to demonstrate the protective effect of a diet rich in omega-3 fatty acids against Parkinsons.

Parkinsons disease is caused by the progressive death of the neurons responsible for producing dopamine, a neurotransmitter closely linked with movement control. The disease is usually diagnosed when 50 to 80% of these neurons are already dead, and there is currently no medication to stop that process.

The Universit Laval research teams findings could help prevent the disease and, potentially, slow down its progression.

The researchers observed that when mice were fed an omega-3 rich diet, they seemed immune to the effect of MPTP, a toxic compound that causes the same damage to the brain as Parkinsons. This compound, which has been used for more than 20 years in Parkinsons research, works faster than the disease itself and is just as effective in targeting and destroying the dopamine-producing neurons in the brain, points out Calon.

By contrast, another group of mice that were fed an ordinary diet developed the characteristic symptoms of the disease when injected with MPTP, including a 31% drop in dopamine-producing neurons and a 50% decrease in dopamine levels.

Analyses revealed that omega-3 fatty acidsin particular DHA (docosahexaenoic acid), a specific type of omega-3had replaced the omega-6 fatty acids already present in the brains of the mice that had been given omega-3 supplementation.

This demonstrates both the importance of diet on the brains fatty acid composition and the brains natural inclination for omega-3 fatty acids, observes Calon. Since concentrations of other types of omega-3s had remained similar in both groups of mice, researchers suggest that the protective effect against Parkinsons comes essentially from DHA.

Another conclusion to be drawn from this finding is that a brain containing a lot of omega-6 fatty acids may be a fertile ground for Parkinsons disease. These fatty acids, abundant in foods rich in either vegetable oil or animal fat, are already under suspicion for their role in the bodys inflammatory response, cardiac disease, arthritis, and Alzheimers. In a balanced diet, the ratio between omega-6 and omega-3 fatty acids should be 4 to 1. However, the average Western diet contains 10 to 20 times more omega-6s than omega-3s.

In North America, the average intake of DHA is between 60 to 80 mg a day, while experts recommend a daily minimum of 250 mg, explains Calon. Our results suggest that this DHA deficiency is a risk factor for developing Parkinsons disease, and that we would benefit from evaluating omega-3s potential for preventing and treating this disease in humans, concludes the researcher.


'/>"/>

Contact: Jean-Franois Hupp
jean-francois.huppe@dap.ulaval.ca
418-656-7785
Universit Laval
Source:Eurekalert

Related biology news :

1. Rain forest protection works in Peru
2. Same gene protects from 1 disease, opens door to another
3. Conservation International and Toyota partner to protect Philippines rain forests
4. Fungus genome yielding answers to protect grains, people and animals
5. Genes that both extend life and protect against cancer identified
6. Intravenous gene therapy protects normal tissue of mice during whole-body radiation
7. Rosemary chicken protects your brain from free radicals
8. Genes identified to protect brassicas from damaging disease
9. Antioxidants could provide all-purpose radiation protection
10. Secure Services Corp. Achieves Milestone in United States Identity Protection with the Launch of the SSC SHAPE Card Management Solution
11. Cells united against cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... -- Report Highlights ... The global synthetic-biology market reached nearly $3.9 billion ... at a compound annual growth rate (CAGR) of 24.0% through ... markets for synthetic biology. - Analyses of global market trends, ... compound annual growth rates (CAGRs) through 2021. - Coverage of ...
(Date:2/7/2017)... , Feb. 7, 2017   MedNet Solutions , ... entire spectrum of clinical research, is pleased to announce ... , its innovative, highly flexible and award winning eClinical ... customers. iMedNet is a proven Software-as-a-Service (SaaS) ... Data Capture (EDC), but also delivers an entire suite ...
(Date:2/6/2017)... According to Acuity Market Intelligence, ongoing ... to continue to embrace biometric and digital identification ... Border Control (ABC) eGates and 1436 Automated Passport ... 163 ports of entry across the globe. Deployments ... combined CAGR of 37%. APC Kiosks reached 75% ...
Breaking Biology News(10 mins):
(Date:2/22/2017)... ... 22, 2017 , ... Kernel , a human intelligence ... (KRS) clinical development program. KRS is a neurotechnology spin-out from the Massachusetts ... applications. The terms of the transaction were not disclosed. , It addition ...
(Date:2/22/2017)... 22, 2017 Scientists propose in Nature ... damage in Gaucher and maybe other lysosomal storage diseases ... costs than current therapies. An international research ... , which also included investigators from the University of ... data Feb. 22. The study was conducted in mouse ...
(Date:2/22/2017)... ... February 22, 2017 , ... LabRoots , the leading ... the world, is pleased to announce the 2nd annual Precision Medicine Virtual Conference. ... online-only conference focused on the development and advancements in precision medicine. , Precision ...
(Date:2/22/2017)... 22, 2017 Origin (Origin Agritech, LLC, a subsidiary of ... provider, and Arcadia (Arcadia Biosciences, Inc., NASDAQ: ... commercializes agricultural productivity traits and nutritional products, today announced their collaboration ... developed in China to the ... ...
Breaking Biology Technology: