Navigation Links
Oligonucleotide Delivery: Biology, Engineering and Development Conference
Date:6/27/2012

Oligonucleotide technologies, such as siRNA, tap into endogenous, highly conserved and specific catalytic mechanisms to efficiently regulate gene expression. As such, they have the potential to enable the development of novel therapeutic options for disease targets previously considered un-druggable by conventional small molecule and biologics means. However, despite the promise, clinical development has been hindered by the challenges encountered by identifying and developing safe and efficacious delivery formulations.

Since its discovery in 1998, RNA silencing has attracted much attention, with over 50,000 peer-reviewed publications, multiple national and international conferences, and significant investment in the biotech and large pharma with the goal of developing new siRNA-based therapies. Despite the interest and investment this has proven to be more difficult that first envisioned. It is widely recognized that there are gaps in our basic understanding on how to best harness this technology for therapeutic use.

The major topics to be discussed are:

Liposomes, nanosomes, polymeric and nano-particulate delivery vehicles
RNA chemical modifications and conjugates to enable delivery
Protein transduction domain as delivery platforms
Mechanisms of cellular uptake and endosomal escape
Biophysical characterization methods
siRNA delivery vehicle toxicology
Local and systemic siRNA delivery case studies

Confirmed Speakers
Achim Aigner, Philipps-University Marburg, Germany
Saghir Akhtar, Kuwait University, Kuwait
Eben Alsberg, Case Western Reserve University, USA
Dan Anderson, MIT, USA
Tomohiro Asai, University of Shizuoka, Japan
Himanshu Brahmbhatt, EnGeneIC Ltd, Australia
Bob Brown, Dicerna, USA
Kenneth Clark, GlaxoSmithKline, UK
Pieter Cullis, University of British Columbia, Canada
Mark E. Davis, California Institute of Technology, USA
'/>"/>

Contact: Kevin Korpics
kevin@engconfintl.org
Engineering Conferences International
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Melting glaciers, enough sand to bury London, and ancient ecosystem engineering
3. Innovative cell printing technologies hold promise for tissue engineering R&D
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. Medical device, health professionals attend first national conference on value-driven engineering
6. NSF report detailing growth in graduate enrollment in science & engineering in the past decade
7. Investigation of American Oriental Bioengineering, Inc. by Securities Lawyers at Goldfarb LLP Law Firm for Potential Shareholder Claim
8. Artificial womb unlocks secrets of early embryo development
9. REST is crucial for the timing of brain development
10. Embryonic development protein active in cancer growth
11. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... A new modeling study suggests that fish consumption ... infant exposure to long-lived contaminants like persistent organic ... a team of researchers including University of Toronto ... Wania, looks at how different levels of environmental ... behavior of chemicals in the body influenced exposure ...
(Date:4/17/2014)... Kansas State University engineer has developed a patented ... improvised explosive devices. The same technique could help ... Steven M. and Kay L. Theede chair in ... engineering, and his research team have created a ... in car trunks. The distance detection method ...
(Date:4/17/2014)... Several parasites and pathogens that devastate honeybees in Europe, ... Africa, but do not appear to be impacting native ... team of researchers., The invasive pests include including ... East African honeybees appear to be resilient to these ... used to control pests in Europe, Asia and the ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Patented research remotely detects nitrogen-rich explosives 2East African honeybees are safe from invasive pests… for now 2East African honeybees are safe from invasive pests… for now 3
... PHILADELPHIAThe Academy of Natural Sciences today announced the revival ... an early 19th-century nature magazine of which only 13 complete ... Museum of Nature was published privately in London between 1810 ... one or two color plates. In it, Perry set out ...
... NY) Matthew Levy, Ph.D., assistant professor of biochemistry ... has been awarded more than $700,000 by Stand Up ... Levy,s work will focus on creating self-guiding drugs that ... serious or unpleasant side effects of current therapies. Dr. ...
... Just three months after the Euro 5 Norm ... car models, researchers at the Technische Universitaet Muenchen (TUM) ... meeting the more stringent Euro 6 emissions standard. A ... Chair of Internal Combustion Engines has succeeded in reducing ...
Cached Biology News:The Academy of Natural Sciences and Temple Press revive rare natural history work in new book 2Einstein receives high-risk/high-reward cancer research funding 2Einstein receives high-risk/high-reward cancer research funding 3Munich lab demonstrates diesel truck engine with barely measurable emissions 2Munich lab demonstrates diesel truck engine with barely measurable emissions 3
(Date:1/15/2014)... (PRWEB) January 15, 2014 Cynvenio, a ... management through the genomic analysis of tumor cells in ... Finder™, a web-based cancer decision support application powered by ... with Cynvenio’s ClearID™ genomic test, Therapy Finder will provide ...
(Date:1/15/2014)... Houston, TX (PRWEB) January 15, 2014 ... Alzheimer’s disease, and about 1 in 3 seniors will ... ( source ). These jaw-dropping figures have shocked many ... function and, hopefully, help prevent these tragic age-related cognitive ...
(Date:1/15/2014)... 15, 2014 Freeslate, Inc ., ... announced that Lupin Limited, one of India’s top five ... Protégé PharmD System for high throughput solid form ... focused on a wide range of quality, affordable generic ...
(Date:1/14/2014)... 2014 Histogen, Inc., a regenerative medicine ... grown under simulated embryonic conditions, today announced that they ... Medical, Inc. for physician-dispensed aesthetic products containing Histogen’s proprietary ... agreement is an amendment to the existing license between ...
Breaking Biology Technology:Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 2Cynvenio Offers New Breast Cancer Therapy Finder Application for its ClearID Breast Cancer Genomic Test 3Biohack Pure Offers 5 Tips for Increasing Memory in 2014 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 2Histogen and Suneva Medical Expand License for Cell Conditioned Media-based Aesthetic Products Internationally 3
... of the bacterium Caulobacter crescentus , researchers at the ... production factory, making useful proteins that can act as vaccines ... Society for General Microbiology,s meeting at Heriot-Watt University, Edinburgh, today ... bacterium that has a single protein layer on its surface. ...
... REDWOOD CITY, Calif., Sept. 4 Cardica, Inc. (Nasdaq: ... received a notice from the Listing Qualifications Department of The ... be delisted from NASDAQ based upon NASDAQ staff,s determination that ... stockholders, equity requirement for continued listing on the NASDAQ as ...
... BEIJING, Sept. 4 /PRNewswire-Asia/ -- Sinovac Biotech Ltd. ... products in China, announced today that,the Ministry of Industry ... issued the initial order to Sinovac to purchase H1N1 ... order, Sinovac is,required to complete the production of 3.3 ...
Cached Biology Technology:Cardica Receives NASDAQ Notification of Non-Compliance 2Sinovac Obtains Initial Order of H1N1 Vaccine from Chinese Central Government 2Sinovac Obtains Initial Order of H1N1 Vaccine from Chinese Central Government 3
...
... polyclonal to MSY2/YBOX2 ( Abpromise ... Antigen: Synthetic peptide derived ... 178-227 of human YBX2. (Note: ... proprietary). ...
... EVO96R and Freedom EVO384R are fast multi-channel ... in three different sizes, with a multi-channel ... deliver significant time saving, with true parallel ... setup of your assays with the Freedom ...
... Aminopropylsilane is perhaps the ... chemistry for microarray experiments. ... for Microarrays provide a ... for printing PCR products ...
Biology Products: