Navigation Links
Oligonucleotide Delivery: Biology, Engineering and Development Conference
Date:6/27/2012

Oligonucleotide technologies, such as siRNA, tap into endogenous, highly conserved and specific catalytic mechanisms to efficiently regulate gene expression. As such, they have the potential to enable the development of novel therapeutic options for disease targets previously considered un-druggable by conventional small molecule and biologics means. However, despite the promise, clinical development has been hindered by the challenges encountered by identifying and developing safe and efficacious delivery formulations.

Since its discovery in 1998, RNA silencing has attracted much attention, with over 50,000 peer-reviewed publications, multiple national and international conferences, and significant investment in the biotech and large pharma with the goal of developing new siRNA-based therapies. Despite the interest and investment this has proven to be more difficult that first envisioned. It is widely recognized that there are gaps in our basic understanding on how to best harness this technology for therapeutic use.

The major topics to be discussed are:

Liposomes, nanosomes, polymeric and nano-particulate delivery vehicles
RNA chemical modifications and conjugates to enable delivery
Protein transduction domain as delivery platforms
Mechanisms of cellular uptake and endosomal escape
Biophysical characterization methods
siRNA delivery vehicle toxicology
Local and systemic siRNA delivery case studies

Confirmed Speakers
Achim Aigner, Philipps-University Marburg, Germany
Saghir Akhtar, Kuwait University, Kuwait
Eben Alsberg, Case Western Reserve University, USA
Dan Anderson, MIT, USA
Tomohiro Asai, University of Shizuoka, Japan
Himanshu Brahmbhatt, EnGeneIC Ltd, Australia
Bob Brown, Dicerna, USA
Kenneth Clark, GlaxoSmithKline, UK
Pieter Cullis, University of British Columbia, Canada
Mark E. Davis, California Institute of Technology, USA
'/>"/>

Contact: Kevin Korpics
kevin@engconfintl.org
Engineering Conferences International
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Columbia Engineering and Penn researchers increase speed of single-molecule measurements
2. Melting glaciers, enough sand to bury London, and ancient ecosystem engineering
3. Innovative cell printing technologies hold promise for tissue engineering R&D
4. 5th Annual Advances in Biomolecular Engineering Symposium
5. Medical device, health professionals attend first national conference on value-driven engineering
6. NSF report detailing growth in graduate enrollment in science & engineering in the past decade
7. Investigation of American Oriental Bioengineering, Inc. by Securities Lawyers at Goldfarb LLP Law Firm for Potential Shareholder Claim
8. Artificial womb unlocks secrets of early embryo development
9. REST is crucial for the timing of brain development
10. Embryonic development protein active in cancer growth
11. Scientists win $2 million to study new pathway in development and maintenance of lymphoma
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/17/2014)... 2014  HITLAB SM announced today its completion of ... adherence to current U.S. Food and Drug Administration (FDA) ... device and smart phone application trials utilizing the highest ... "HITLAB is determined to improve global healthcare access, quality, ...
(Date:12/17/2014)... Dec. 16, 2014  Automation is fundamentally transforming the travel ... international borders. Over the past decade, ePassports, biometric readers, ... self process through border control via eGates and Automated ... airports, seaports, and land borders across the globe. ...
(Date:12/11/2014)... Markets , http://photos.prnewswire.com/prnh/20130307/600769 ... addition of the "Biometrics Market in India 2015-2019" ... major trend emerging in this market is the adoption ... than one characteristic of an individual for verification and ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2
... often behave differently than temperate soils when being farmed. ... cultivated. With food shortages looming and soil quality declining ... and sub-tropical farming more productive and sustainable. New research ... a winter cover crop is most effective in retaining ...
... Georgia researchers have developed a new technology that ... from readily available non-food crops, such as Bermudagrass, ... "Producing ethanol from renewable biomass sources such as ... in large quantities," said Joy Peterson, professor of ...
... the U.S. will be overweight or obese by 2030, with ... $956.9 billion, according to researchers at the Johns Hopkins Bloomberg ... Quality and the University of Pennsylvania School of Medicine. Their ... Obesity . "National survey data show that the ...
Cached Biology News:New UGA biomass technology dramatically increases ethanol yield from grasses and yard waste 2New UGA biomass technology dramatically increases ethanol yield from grasses and yard waste 3Study suggests 86 percent of Americans could be overweight or obese by 2030 2
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently was ... Pre-Conference seminar on probiotics in San Diego, CA. , ... conference for health care professionals. This year’s pre-conference seminar was ... in health. Dr. Leyer spoke about the emerging topics and ...
(Date:1/22/2015)... , Nueva Jersey , 22 de enero de ... Biomedical Research abre hoy su llamada a nominaciones para ... investigación científica ha hecho, o tiene el potencial para ... humana. Las nominaciones se aceptarán hasta el 15 de ...
(Date:1/22/2015)... PRINCETON, N.J. , Jan. 22, 2015  Derma ... tissue regeneration company focused on advanced wound care, ... from placental tissues, have been added to the ... announcement increases the opportunity for the AMNIOEXCEL® and ...
(Date:12/24/2014)...  Vermillion, Inc. (Nasdaq:   VRML), a bio-analytical solutions ... the Company closed its previously announced private placement ... W. Schuler , Birchview Fund LLC and several ... offering expenses.  The proceeds will be used for ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... Biomedical Research Program Awards Peer-Reviewed Grant, SARASOTA, Fla., ... was awarded the Florida Department of Health and James ... for its advanced cancer research in using B-amyloid protein ... in the amount of $100,000 was awarded to Roskamp,s,Investigator ...
... Barr Pharmaceuticals,Inc. (NYSE: BRL ) today ... a challenge of the patents listed by TAP,Pharmaceuticals ... Disintegrating Tablets (lansoprazole), 15mg and,30mg., Barr filed ... IV certification for a generic Prevacid SoluTab product ...
... Va., June 10 Diffusion Pharmaceuticals,LLC, a clinical-stage ... life-threatening unmet medical needs, today announced,the addition of ... (Photo: http://www.newscom.com/cgi-bin/prnh/20080610/NETU101 ), Mr. ... Virginia National Bank in,Charlottesville, Virginia. He also is ...
Cached Biology Technology:Roskamp Institute Wins Grant for Lung Cancer Research 2Barr Confirms Patent Challenge of Prevacid(R) SoluTab(TM) Delayed-Release Orally Disintegrating Tablets, 15mg and 30mg 2Barr Confirms Patent Challenge of Prevacid(R) SoluTab(TM) Delayed-Release Orally Disintegrating Tablets, 15mg and 30mg 3Diffusion Pharmaceuticals Announces Addition of Mark T. Giles to its Board of Directors 2
Human SPARC-like 1 Biotinylated Affinity Purified PAb...
Request Info...
Any form, any size, any number of mutageneses. ExonBio provides the best service with double sequecing to make sure the success of the mutagenesis....
Request Info...
Biology Products: