Navigation Links
Old stain in a new combination
Date:5/20/2009

New combinations of agents based on the oldest synthetic malaria drug, the methylene blue stain, can curb the spread of malaria parasites and make a significant contribution to the long-term eradication called for by the international "Roll Back Malaria Initiative." In a study on 160 children with malaria in Burkina Faso, specialists in tropical medicine from the Heidelberg University Hospital have shown that in combination with newer malaria drugs, methylene blue prevents the malaria pathogen in infected persons from being re-ingested by mosquitoes and then transmitted to others and is thus twice as effective as the standard therapy. The results of the study were published in May 2009 in the online journal PLoS One.

Malaria is still one of the deadliest tropical diseases. Every year, 300 million people are infected with malaria and more than one million of them die or suffer severe brain damage. Children under five years are particularly susceptible.

Malaria pathogens need humans and mosquitoes

When the Anopheles mosquito bites, the malaria parasites (plasmodia) in the saliva of the mosquito enter the human body, reproduce in liver cells and then attack the red blood cells. This causes severe symptoms such as high fever or anemia; children in particular can even fall into a coma. During reproduction in the human body, some parasites develop into special reproductive cells, gametocytes. If they are ingested by an Anopheles mosquito, they continue to reproduce in the mosquito. The cycle is complete.

The gametocytes are the key for the spread of malaria by the Anopheles mosquito. Common malaria drugs known as artemisinins block reproduction of the parasites in the human body and reduce the number of gametocytes in blood by half. This makes the transmission of the parasite to the mosquito more difficult but does not completely prevent it. "We urgently need alternative therapies that are effective against the gam
'/>"/>

Contact: Prof. Olaf Mueller
Olaf.mueller@urz.uni-heidelberg.de
49-062-215-65035
University Hospital Heidelberg
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Grasslands: The future of sustainable agriculture
2. Going bananas for sustainable research -- scientists create fuel from African crop waste
3. K-State biologist collaborating with researchers in Africa on grassland sustainability, biodiversity
4. Organizational Change Management for Sustainability: The Harvard Case Study
5. Biofuels can provide viable, sustainable solution to reducing petroleum dependence
6. Symposium at UH will address how to put sustainability into practice
7. Biggest ever public investment in bioenergy to help provide clean, green and sustainable fuels
8. TXOTX, coordinated international project to contribute to sustainability of the marine resources
9. Abundance of ladybugs in olive orchards is an indicator of health and sustainability
10. Next generation microscopy: No stain, big gain
11. New publishing partnership for Energy for Sustainable Development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... , Jan. 13, 2015  Today, FreeWavz ( www.FreeWavz.com ... its crowdfunding campaign on Fundable, https://www.fundable.com/freewavz . ... of production capacity to meet customer demand. ... - http://photos.prnewswire.com/prnh/20150113/168790 Invented ...
(Date:1/22/2015)... 15, 2015  BellBrook Labs, a leader in high ... launch of a TR-FRET (time resolved Forster resonance ... Assay, a high throughput screening assay for glycosyltransferases ... allow for sensitive detection of hundreds of human ...
(Date:1/22/2015)... NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) a biometric authentication ... success of the Wocket™ smart wallet at CES 2015 in ... as one of the "11 Hot Products at CES" in a review ... So Far" by Newseveryday.com and "The top 10 gadgets from CES 2015" ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2BellBrook Labs Launches a High Throughput Screening Assay for Glycosyltransferases with TR-FRET Readout 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 2CES Response for NXT-ID's Wocket Smart Wallet Kicks Off 2015 3
... occur in sports and in combat, but health experts ... head movements during these activities pose the greatest risks ... have developed a powerful new computer-based process that helps ... injuries. This approach could lead to new medical treatment ...
... 12, 2013The foodborne bacteria Listeria monocytogenes sickens ... many more worldwide, killing about 25-30% of those infected. ... L. monocytogenes , and current methods for detecting the ... method for developing an inexpensive biosensor to detect the ...
... maxillary sinuses. Those bulbous pouches on either side of the ... sinus infections than anything else. They were thought to be ... present value. Yet researchers led by the University of ... role in the shape and function of the human nose, ...
Cached Biology News:Computer model may help athletes and soldiers avoid brain damage and concussions 2Computer model may help athletes and soldiers avoid brain damage and concussions 3Low-cost nano-biosensor to detect foodborne pathogen that causes listeriosis 2Low-cost nano-biosensor to detect foodborne pathogen that causes listeriosis 3The nose's unheralded neighbor 2The nose's unheralded neighbor 3
(Date:2/27/2015)... 2015 FamilyFarms Group is pleased to ... State Line Farms, received the 2015 Tomorrow’s Top Producer ... the age of 35, who has demonstrated excellence in ... to win the Tomorrow's Top Producer Horizon Award. Every ... Top Producer Award and learning from their experiences. It ...
(Date:2/27/2015)... PureTech , a science and technology R&D company focused  ... in the healthcare sector, announced today the appointment of ... the Board of Directors of Sanofi, to its Board ... pleasure to know Chris for many years and I ... more closely now," said Dr. Robert Langer , ...
(Date:2/26/2015)... VIEW, Calif. , Feb. 26, 2015  23andMe, ... of Kate Black as Privacy Officer and ... federal, and state privacy laws as well as health ... regulatory team, she will be responsible for reviewing, updating ... customers in the U.S. and abroad. She joined the ...
(Date:2/26/2015)... 26, 2015   Regulus Therapeutics Inc . (NASDAQ: ... discovery and development of innovative medicines targeting microRNAs, today ... and Chief Executive Officer of Regulus, will present a ... Annual Healthcare Conference on Wednesday, March 4, 2015 ... at the Boston Marriott Copley Place.  ...
Breaking Biology Technology:Matt Sims Receives the 2015 Tomorrow’s Top Producer Horizon Award 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 2Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 3Christopher Viehbacher, former CEO of Sanofi, Joins PureTech's Board of Directors 423andMe Appoints Kate Black as Privacy Officer and Corporate Counsel 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 2Regulus to Present at Cowen and Company 35th Annual Healthcare Conference 3
... Three student teams with high-tech diagnostic and surgical ... Alliance,s annual BMEidea awards at MD&M East Conference ... YORK, June 10 Today three collegiate biomedical ... The winners in the annual Biomedical Engineering ...
... BioMarin Pharmaceutical Inc. (Nasdaq: BMRN ) announced ... for Kuvan(R) (sapropterin dihydrochloride) as an oral treatment for patients ... for a shortened submission review of 180 days versus the ... application for Kuvan in Canada in the third quarter of ...
... M.D., a Professor of Medicine at the University of Colorado ... Techne Corporation Board of Directors, was recently recognized with two ... Dr. Dinarello, Ralph M. Steinman, M.D., of Rockefeller University ... Institute , were the 2009 recipients of the Albany Medical ...
Cached Biology Technology:NCIIA Honors Top Collegiate Biomedical Engineering Teams 2NCIIA Honors Top Collegiate Biomedical Engineering Teams 3Kuvan Receives Priority Review Status From Health Canada 2Kuvan Receives Priority Review Status From Health Canada 3Kuvan Receives Priority Review Status From Health Canada 4Techne Corporation Board Member Recognized 2
... synthetic peptide for OPA1-01009, OPEP-01009 is a 16 amino acid ... DNA fragmentation factor (DFF). The sequence of this peptide ... - K - S - V - K - L ... - P - R - K(18). This peptide ...
... Two-Color RNA Spike-In Kit contains in vitro ... to complementary control probes on Agilents microarrays, ... serve as a positive microarray control in ... This kit is a required component of ...
... Mega Western Protein Array was developed using ... Protein Arrays are manufactured using high quality ... A protein sample from each of 30 ... Protein molecular weight marker on a large ...
... For applications not requiring confocal, the BD ... to the Pathway 435. And, the Pathway ... later applications require it. ... elect to use the laser autofocus, camera ...
Biology Products: