Navigation Links
Old drug may point the way to new treatments for diabetes and obesity
Date:2/10/2013

ANN ARBOR Researchers at the University of Michigan's Life Sciences Institute have found that amlexanox, an off-patent drug currently prescribed for the treatment of asthma and other uses, also reverses obesity, diabetes and fatty liver in mice.

The findings from the lab of Alan Saltiel, the Mary Sue Coleman director of the Life Sciences Institute, are scheduled to be published online Feb. 10 in the journal Nature Medicine.

"One of the reasons that diets are so ineffective in producing weight loss for some people is that their bodies adjust to the reduced calories by also reducing their metabolism, so that they are 'defending' their body weight," Saltiel said. "Amlexanox seems to tweak the metabolic response to excessive calorie storage in mice."

Different formulations of amlexanox are currently prescribed to treat asthma in Japan and canker sores in the United States. Saltiel is teaming up with clinical-trial specialists at U-M to test whether amlexanox will be useful for treating obesity and diabetes in humans. He is also working with medicinal chemists at U-M to develop a new compound based on the drug that optimizes its formula.

The study appears to confirm and extend the notion that the genes IKKE and TBK1 play a crucial role for maintaining metabolic balance, a discovery published by the Saltiel lab in 2009 in the journal Cell.

"Amlexanox appears to work in mice by inhibiting two genesIKKE and TBK1that we think together act as a sort of brake on metabolism," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system to burn more, and possibly store less, energy."

Using high-throughput chemical screening at LSI's Center for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox. They then demonstrated that amlexanox had profound beneficial effects in both genetic and dietary-induce
'/>"/>

Contact: Laura J. Williams
laurajw@umich.edu
734-615-4862
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bluemetal Architects appoints David Le Penske as Vice President of Health & Life Sciences
2. Summit of osteoporosis experts from CIS countries issue 5-point call for action
3. Scientists pinpoint molecular signals that make some women prone to miscarriage
4. Serendipity points to new potential target and therapy for melanoma
5. Research pinpoints key gene for regenerating cells after heart attack
6. Fish ear bones point to climate impacts
7. Protein injection points to muscular dystrophy treatment
8. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
9. New study to examine ecological tipping points in hopes of preventing them
10. Fossil study helps pinpoint extinction risks for ocean animals
11. Remarkable enzyme points the way to reducing nitric acid use in industry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/5/2015)... -- According to a new market research ... Vertical (BFSI, Airport, IT & Telecom, Utilities, Education, Defense ... 2020", published by MarketsandMarkets, defines and segments the Physical ... The global PIAM Market is estimated to grow from ... at a CAGR of 14.9 % from 2014 to ...
(Date:8/4/2015)... DUBLIN , Aug. 04, 2015 /PRNewswire/ ... ( http://www.researchandmarkets.com/research/nvh7k2/digital_forensics ) has announced the addition ... Component (Hardware, Software, and Service), Sub-Segment (Computer ... Cloud Forensics), Tool Types, Service, Vertical and ... report to their offering. By ...
(Date:7/31/2015)... Den 10. internationale konference om Genomik (ICG-10, ... - 25. oktober i Shenzhen , ... i år. Siden starten i 2006 er ICB blevet ... og er en af de mest dynamiske, entusiastiske og ... nylige gennembrud og fremskridt inden for ,omik,-forskning, som yderligere ...
Breaking Biology News(10 mins):Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4Digital Forensics Market - The Market Represents a Compound Annual Growth Rate (CAGR) of 11.3% From 2015 to 2020 2Den 10. internationale konference om Genomics (ICG-10) åbner i oktober 2
... who held their breath for several minutes had elevated levels ... a new study from the Journal of Applied Physiology ... and leaves open the question of whether lengthy apnea (breath-holding) ... "The results indicate that prolonged, voluntary apnea affects the integrity ...
... Peter Wilf, associate professor of geosciences, has been ... 2012 by the Paleontological Society. The Paleontological ... other work in paleontology is highly regarded and ... The Lecturers are excellent speakers who communicate the ...
... (August 3, 2009) La Jolla Institute for Allergy ... a role in allergy onset, instead have discovered its ... be important in myeloproliferative diseases and some types of ... disorders characterized by an overproduction of blood cells by ...
Cached Biology News:Holding breath for several minutes elevates marker for brain damage 2Holding breath for several minutes elevates marker for brain damage 3Holding breath for several minutes elevates marker for brain damage 4La Jolla Institute discovers novel tumor suppressor 2La Jolla Institute discovers novel tumor suppressor 3
(Date:9/2/2015)... -- Research and Markets ( ... PharmaBiotech,s new report "DNA Sequencing - Technologies, ... This report briefly reviews basics of human ... applications. Current large and small sequencers are described ... of sequencing are described including those for genetics, ...
(Date:9/2/2015)... , Sep. 02, 2015 ... has announced the addition of Jain PharmaBiotech,s new ... to their offering. This report ... a characteristic that can be objectively measured and ... pathogenic processes as well as pharmacological responses to ...
(Date:9/2/2015)... 2015 Biovista Inc. is glad ... 2015 BeHEARD science challenge, a global competition hosted by ... access to the latest life science innovations and technologies. ... pathway analytics capability to support Steven Laffoon ... study of Niemann-Pick Disease Type A (NPA), a rare ...
(Date:9/2/2015)... -- Australian prostate cancer technology company Minomic International Ltd ... ,outstanding, science that uses its patented antibody. ... prostate cancer diagnostic test known as MiCheck® next year, ... the peer-reviewed Australian Museum Eureka Science Prize for ... prize is awarded for ground breaking research that has ...
Breaking Biology Technology:Global DNA Sequencing Technologies Report 2015: Profiles of 130 Companies Involved in Sequencing and their 140 Collaborations 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 2Updated 2015 Biomarkers Report - Latest Technologies, Markets and Companies Insights to 2024 with over 1,000 References 3Biovista Sponsors Wylder Nation Foundation's Research on Acid Sphingomyelinase Deficiency 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 2Prostate Cancer Company Minomic Wins Prestigious Eureka Science Prize 3
... Masimo (Nasdaq: MASI ) ... accuracy and value of its noninvasive and continuous hemoglobin ... the Society of Critical Care Medicine (SCCM) Annual ... multi-professional critical care event of the year, the SCCM ...
... Soligenix, Inc. (OTC Bulletin Board: SNGX ... announced today that the US Food and Drug Administration ... the prevention of ricin intoxication.  RiVax™ is a proprietary ... chain of ricin toxin which induces ricin neutralizing antibodies ...
... new image and cell technologies have for the first ... red blood cells. The researchers, from the Walter and ... of Technology, Sydney (UTS), achieved this long-held aim using ... a technology platform new to Australia. The detailed ...
Cached Biology Technology:New Clinical Study Finds Masimo Noninvasive Hemoglobin Accurate in Patients with Critically Low Hemoglobin Levels 2New Clinical Study Finds Masimo Noninvasive Hemoglobin Accurate in Patients with Critically Low Hemoglobin Levels 3New Clinical Study Finds Masimo Noninvasive Hemoglobin Accurate in Patients with Critically Low Hemoglobin Levels 4New Clinical Study Finds Masimo Noninvasive Hemoglobin Accurate in Patients with Critically Low Hemoglobin Levels 5Soligenix Receives FDA Orphan Drug Designation for RiVax™ for the Prevention of Ricin Intoxication 2Soligenix Receives FDA Orphan Drug Designation for RiVax™ for the Prevention of Ricin Intoxication 3Soligenix Receives FDA Orphan Drug Designation for RiVax™ for the Prevention of Ricin Intoxication 4Soligenix Receives FDA Orphan Drug Designation for RiVax™ for the Prevention of Ricin Intoxication 5Soligenix Receives FDA Orphan Drug Designation for RiVax™ for the Prevention of Ricin Intoxication 6Malaria parasite caught red-handed invading blood cells 2Malaria parasite caught red-handed invading blood cells 3
... Stem Cell Functional Identification Kit contains ... be used for the short-term maintenance, ... the induction of NSCs into astrocyte, ... panel consisting of mouse anti-human Nestin, ...
GM130 Immunogen: Recombinant purified rat GM130 Family / Subclass 1: Signal Transduction Storage: 4 C...
NATIVE RAT OSTEOCALCIN...
... x W x H): 17 3/4" ... lbsCapacity: 12 slidesTime: Programmable 0 - 100 ... and hybridization steps 40 user programmable protocols ... Fixed temperature) Rapid temperature ramp-up from 37 ...
Biology Products: