Navigation Links
Old drug may point the way to new treatments for diabetes and obesity
Date:2/10/2013

ANN ARBOR Researchers at the University of Michigan's Life Sciences Institute have found that amlexanox, an off-patent drug currently prescribed for the treatment of asthma and other uses, also reverses obesity, diabetes and fatty liver in mice.

The findings from the lab of Alan Saltiel, the Mary Sue Coleman director of the Life Sciences Institute, are scheduled to be published online Feb. 10 in the journal Nature Medicine.

"One of the reasons that diets are so ineffective in producing weight loss for some people is that their bodies adjust to the reduced calories by also reducing their metabolism, so that they are 'defending' their body weight," Saltiel said. "Amlexanox seems to tweak the metabolic response to excessive calorie storage in mice."

Different formulations of amlexanox are currently prescribed to treat asthma in Japan and canker sores in the United States. Saltiel is teaming up with clinical-trial specialists at U-M to test whether amlexanox will be useful for treating obesity and diabetes in humans. He is also working with medicinal chemists at U-M to develop a new compound based on the drug that optimizes its formula.

The study appears to confirm and extend the notion that the genes IKKE and TBK1 play a crucial role for maintaining metabolic balance, a discovery published by the Saltiel lab in 2009 in the journal Cell.

"Amlexanox appears to work in mice by inhibiting two genesIKKE and TBK1that we think together act as a sort of brake on metabolism," Saltiel said. "By releasing the brake, amlexanox seems to free the metabolic system to burn more, and possibly store less, energy."

Using high-throughput chemical screening at LSI's Center for Chemical Genomics to search for compounds that inhibit IKKE and TBK1, the researchers hit upon an approved off-patent drug: amlexanox. They then demonstrated that amlexanox had profound beneficial effects in both genetic and dietary-induce
'/>"/>

Contact: Laura J. Williams
laurajw@umich.edu
734-615-4862
University of Michigan
Source:Eurekalert

Page: 1 2

Related biology news :

1. Bluemetal Architects appoints David Le Penske as Vice President of Health & Life Sciences
2. Summit of osteoporosis experts from CIS countries issue 5-point call for action
3. Scientists pinpoint molecular signals that make some women prone to miscarriage
4. Serendipity points to new potential target and therapy for melanoma
5. Research pinpoints key gene for regenerating cells after heart attack
6. Fish ear bones point to climate impacts
7. Protein injection points to muscular dystrophy treatment
8. University of Maryland School of Medicine, NIH study pinpoints brain areas role in learning
9. New study to examine ecological tipping points in hopes of preventing them
10. Fossil study helps pinpoint extinction risks for ocean animals
11. Remarkable enzyme points the way to reducing nitric acid use in industry
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/16/2014)... Geoscientists from the north-central U.S. and beyond will convene ... new science, expand on existing science, and explore the ... a special emphasis on applied geology, paleontology, and mid-continent ... on Thursday by Dr. Kirk Johnson, Sant Director of ... The meeting is hosted by the University of Nebraska-Lincoln. ...
(Date:4/16/2014)... do all of our movements, thoughts and feelings ... another, and recent studies have suggested that some of ... cells known as astrocytes may be listening in on, ... a new mouse study suggests that astrocytes might only ... when the neurons get really excited about something. This ...
(Date:4/16/2014)... RICHLAND, Wash. Geologic and soil processes are to ... throughout Ohio, according to a study published recently in ... analysis of 842 soil samples from all corners of ... than the screening level of concern recommended by the ... the public, say the authors, who note that regulatory ...
Breaking Biology News(10 mins):Walking with mammoths and exploring mid-continental geology 2Walking with mammoths and exploring mid-continental geology 3Walking with mammoths and exploring mid-continental geology 4Eavesdropping on brain cell chatter 2Eavesdropping on brain cell chatter 3Significant baseline levels of arsenic found in Ohio soils are due to natural processes 2Significant baseline levels of arsenic found in Ohio soils are due to natural processes 3Significant baseline levels of arsenic found in Ohio soils are due to natural processes 4
... thought that land plants evolved from stonewort-like algae. However, new ... Evolutionary Biology shows that the closest relatives to land ... Ancestors of green plants began to colonise the land ... that they evolved from streptophyte algae (a group of green, ...
... Researchers at The University of Western Ontario have discovered a ... vessels in tissues that are starved of oxygen. Dr. ... Medicine & Dentistry developed a strategy in which a biological ... the same time that the body is making its own ...
... Whether you,re talking about genes, or neurons, or the workings ... a matter of proteins. So understanding what protein complexes look ... out what makes cells tick. By harnessing the unique properties ... technique that can help deduce the orientation of specific proteins ...
Cached Biology News:Ancestors of land plants revealed 2Successful strategy developed to regenerate blood vessels 2Polarized microscopy technique shows new details of how proteins are arranged 2Polarized microscopy technique shows new details of how proteins are arranged 3
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... MINRAD International, Inc. (Amex: BUF ), announced ... or 50 positions. , , ... have taken this difficult, but necessary action to reduce our ... current adverse financial condition as we discussed in our recently ...
... To VisualSonics to Enable Molecular Imaging ... in the Pursuit of Neurology, Regenerative Medicine, Inflammation, and, ... , TORONTO and SAN ANTONIO, TX, Nov. ... announced the official signing of a licensing agreement providing ...
... Colo., Nov. 20 MicroPhage, Inc., http://www.microphage.com , today ... brings total capital raised to $11 million. Investors ... investors. All funds to,date have come from private ... will apply proceeds of its financing to complete the ...
Cached Biology Technology:MINRAD International, Inc. Announces Reduction in Workforce 2VisualSonics and Seno Medical Instruments Sign Exclusive Opto-Accoustic Licensing Agreement for Preclinical Research 2VisualSonics and Seno Medical Instruments Sign Exclusive Opto-Accoustic Licensing Agreement for Preclinical Research 3MicroPhage Closes Latest Financing 2
... to the maintenance of appropriate levels ... important and diverse as those involved ... stress response, antigen presentation, modulation of ... cell cycle regulation, transcription, and signalling ...
... protein identification Service includes 1. Scanning ... spots 3. High-sensitive tryptic in-gel digestion ... samples for MALDI-MS 5. Acquisition of ... MALDI-MS (Bruker ultraflex TOF/TOF) 6. Acquisition ...
Each Yeast-GFP clone represents an individual S. cerevisiae strain containing an open reading frame with a C-terminal Aequorea Victoria GFP (S65T) fusion tag....
... is a new product number, created ... If showing no availability yet, please ... (R4276) or contact customer service for ... surface, easy grip) Mfr ...
Biology Products: