Navigation Links
Observing live gene expression in the body
Date:6/30/2013

Most of our physiological functions fluctuate throughout the day. They are coordinated by a central clock in the brain and by local oscillators, present in virtually every cell. Many molecular gearwheels of this internal clock have been described by Ueli Schibler, professor at the Faculty of Science of the University of Geneva (UNIGE), Switzerland. To study how the central clock synchronizes subordinate oscillators, the researcher's group used a variety of genetic and technological tools developed in collaboration with a team of UNIGE physicians. In this way, the scientists were able to directly observe the bioluminescence emitted by 'clock genes' in mice for several months. This biotechnology is applicable to numerous sectors of biomedical research, which attracted the attention of the editors from the journal "Genes & Development".

In mammals, there are many behaviors and biological functions that are regulated by internal clocks. Most of our cells have one, made from a family of 'clock genes', whose cyclic activity reaches a specific peak in 24 hours. These local oscillators are synchronized by a central 'pacemaker' in the brain which adjusts to light.

The firefly lights the way

The use of genetic engineering techniques enabled the study of molecular mechanisms that activate clock genes directly in cultured mammalian cells: 'We have coupled several of these genes to that of luciferase, the enzyme used by the female firefly for producing green light to attract males,' explained Ueli Schibler, member of the National Research Center Frontiers in Genetics. When a specific clock gene is activated in a cell that was transformed in this way, the light signal emitted can be measured using a highly sensitive bioluminescence detector. However, this device, which is capable of detecting signals on the order of a few photons, cannot be used for studying whole organisms. The contribution of Andr Liani's mechanical workshop, a
'/>"/>

Contact: Ueli Schibler
ueli.schibler@unige.ch
41-223-796-175
Universit de Genve
Source:Eurekalert

Page: 1 2

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. A new application allows online statistical analysis of gene-expression data
3. Measuring progesterone receptor expression to improve hormone-receptor-positive cancer management
4. Fish show autism-like gene expression in water with psychoactive pharmaceuticals
5. Controlling gene expression with hydrogen peroxide switches
6. Molecular economics: New computer models calculate systems-wide costs of gene expression
7. Controlling gene expression: How chromatin remodelers block a histone pass
8. Study finds how BPA affects gene expression, anxiety; Soy mitigates effects
9. Nutrient in eggs and meat may influence gene expression from infancy to adulthood
10. Whitehead scientists identify major flaw in standard approach to global gene expression analysis
11. Oxidative stress and altered gene expression occurs in a metabolic liver disease model
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2015)... 9, 2015  Synaptics Inc. (NASDAQ: SYNA ), a ... it will report financial results for the fourth quarter ... after the close of market. The company will host ... 2:00 p.m. PT (5:00 p.m. ET), during which management ... on the live call, analysts and investors should dial ...
(Date:7/8/2015)... YORK , July 8, 2015  BD (Becton, ... BD & Guidepoint Mentor, a new program ... Guidepoint,s expert network services. BD is ... to improve healthcare delivery and outcomes and, with the ... entrepreneur will be able to directly engage with industry ...
(Date:7/7/2015)... OXFORD, Conn. , July 7, 2015 NXT-ID, Inc. ... company focused on the growing mobile commerce market announces a revised ... airing this week. The commercial will air on CNBC in ... Los Angeles and San Francisco ... The commercial focuses on Wocket,s ability to replace all the ...
Breaking Biology News(10 mins):Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3
... tiny plants living in the ocean need iron for energy ... for one, they can,t exactly turn to natural iron ... So where does their iron come from? New research ... on the seafloor: minute particles (called nanoparticles) of pyrite, or ...
... and girls have put many of the trappings of teenagerhood behind ... some of the brain resculpting that characterizes the decade of adolescence ... in a new study that measured brainwaves of subjects in their ... kinds of neurological changes underway in a teen brain is a ...
... chemistry professors have invented a new polarimeter, a basic ... of transverse waves, such as light waves, that could ... has now patented the device. Certain compounds ... polarized light. Plane polarized light is light whose electric ...
Cached Biology News:As good as gold 2Study: Pace of brain development still strong in late teens 2Chemistry researchers receive patent for new scientific measurement instrument 2
(Date:7/30/2015)... , July 30, 2015 AACC ... to the 2015 AACC Annual Meeting & Clinical ... from July 26–30. The meeting showcased revolutionary advancements ... the ability of healthcare providers to diagnose patients ... effective medical treatment. As of ...
(Date:7/30/2015)... and Dallas, TX, USA (PRWEB) , ... July ... ... innovative nano and microsystems, has appointed Francois Vieillard as Sales & Marketing Director. ... at executive positions, Francois Vieillard will be responsible for reinforcing Tronics’ business development ...
(Date:7/30/2015)... -- According to a new market research ... PKPD, Trial Design, Toxicity Prediction, In-house, Contract Service), by ... End Users - Global Forecast to 2020", published by ... 2,107.99 million by 2020 from USD 1,034.93 million in ... Browse more than 75 market ...
(Date:7/30/2015)... CITY, Kan. , July 30, 2015 /PRNewswire/ ... ), a pet therapeutics company focused on the ... for companion animals, today announced that its strategic ... from a dose confirmation study of AT-016, an ... Aratana for the treatment of osteoarthritis pain in ...
Breaking Biology Technology:Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4Tronics appoints Francois Vieillard as Sales and Marketing Director 2Biosimulation Market Worth 2,107.99 Million USD by 2020 2Biosimulation Market Worth 2,107.99 Million USD by 2020 3Biosimulation Market Worth 2,107.99 Million USD by 2020 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 2Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 3Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 4Aratana Therapeutics Announces Positive Pilot Field Study for AT-016 5
... The streaming of real-time information across your field of vision ... a prototype contact lens that could potentially provide the wearer ... today, 22 November, in IOP Publishing,s Journal of Micromechanics ... demonstrated its safety by testing it on live eyes. There ...
... Trieste (Italy), November 21, 2011. CNR Rao, Linus Pauling ... Center for Advanced Scientific Research and immediate past president ... world, has been named the winner of the 2011 ... which is designed to give international recognition and visibility ...
... A program co-funded by the Air Force Office of Scientific Research ... Inventions of 2011. Drs Ali Aliev, Yuri Gartstein ... have succeeded in producing what is technically referred to as the ... some in the popular press have termed it: an ,invisibility cloak,." ...
Cached Biology Technology:Terminator-style info-vision takes step towards reality 2CNR Rao wins 2011 Ernesto Illy Trieste Science Prize 2CNR Rao wins 2011 Ernesto Illy Trieste Science Prize 3CNR Rao wins 2011 Ernesto Illy Trieste Science Prize 4
KOR-1 (C-20)...
...
VAP-1 (S-13)...
... at the 3, 3', 4, and 4' ... an internal standard for the quantification of ... spectrometry. PGE2 is one of the primary ... of the most widely investigated prostaglandins. Its ...
Biology Products: