Navigation Links
OGI's investment in cytognomix contributes to the Shannon Human Splicing Pipeline's success
Date:4/29/2013

TORONTO, ON, April 29, 2013 - Ontario Genomics Institute (OGI) congratulates Cytognomix on the success of the Shannon Human Splicing Pipeline, which was recently purchased by the National Cancer Institute (NCI) in the U.S. In 2009, OGI invested in Cytognomix through its Pre-commercialization Business Development Fund (PBDF).

Understanding the wealth of data generated by next-generation sequencing is essential to determining which mutations are clinically significant. Cytognomix's Shannon pipeline assesses the millions of variants of unknown significance detected in cancer genetic testing by predicting mRNA splicing abnormalities. This technology improves accuracy and ease of data interpretation, saving time and reducing mistakes.

Investigators at NCI are using the Shannon pipeline to evaluate somatic and germline variants observed in tumor genome next generation sequences for their potential effects on splicing. According to Dr. Mike Nickerson, Cancer and Inflammation Program, NCI, the analytic tool is being applied to evaluate a variety of variants which can be difficult to interpret in terms of their effects on protein function. Analysis of variants for potential effects on splicing provides a tool to distinguish deleterious mutations from passenger variants and generates hypotheses that can be experimentally evaluated using PCR of reverse-transcribed tumor RNA.

"Cytognomix's Shannon pipeline is resolving significant data interpretation issues in cancer research," said Mark Poznansky, CEO, OGI. "It is rewarding to see the companies we invest in succeed and grow. OGI's investment provided Cytognomix with early stage funding, which allowed them to take important next steps toward bringing their products to market."

According to Peter Rogan, CEO of Cytognomix, "Interpreting gene variants of unknown clinical significance is one of the most important challenges in human genomics. While much effort has been focused on gathering existing knowledge about published variants in databases, our Shannon pipeline discovers previously unrecognized functions of non-coding variants. Cytognomix's mutation analysis software products have been validated in numerous peer-reviewed journal publications. We are pleased that the NCI has chosen the Shannon mRNA splicing mutation pipeline to accelerate their understanding of various forms of cancer."

OGI's PBDF program has invested in opportunities based in genomics, proteomics or associated technologies that fall in the proof-of-principle (validation) phase of research and that have the short-term potential to secure a significant next step towards the marketplace. Previous recipients have included Ontario universities, research institutes and companies.


'/>"/>

Contact: Christine Beyaert
cbeyaert@ontariogenomics.ca
416-673-6597
Ontario Genomics Institute
Source:Eurekalert

Related biology news :

1. IU biologists offer clearer picture of how protein machine systems tweak gene expression
2. Microbiologists can now measure extremely slow life
3. American Society of Plant Biologists honors early career women scientists
4. Interventional radiologists see significant symptom relief in MS patients
5. In search for a vaccine, IU biologist receives $2.3 million to explore chlamydia genomics
6. Penn biologists identify a key enzyme involved in protecting nerves from degeneration
7. University of Toronto biologists predict extinction for organisms with poor quality genes
8. UC Riverside plant cell biologist receives top scientific honor
9. Biologists turn back the clock to understand evolution of sex differences
10. Radiologists study necessity of additional imaging recommendations in PET/CT oncologic reports
11. Anthropologist finds explanation for hominin brain evolution in famous fossil
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/9/2020)... (PRWEB) , ... March 09, ... ... enterprises witnessed a steep growth rate of 64% last year, as enterprises ... new research from Everest Group. Unfortunately, only 13% of all transformation efforts ...
(Date:3/5/2020)... ... 2020 , ... In September 2016, stem cell biotechnology company ... the first, and still only, available technology that provides the cell-specific count or ... about the number and quality of therapeutic tissue stem cells are unable to ...
(Date:3/3/2020)... HILLS, Calif. (PRWEB) , ... March 03, 2020 , ... ... spinal levels with the dualX Expanding Interbody Fusion System. , The landmark ... Fresno, CA. After the case Dr. Najafi noted, “dualX has completely changed the ...
Breaking Biology News(10 mins):
(Date:3/10/2020)... ... March 10, 2020 , ... ... to announce the addition of Carson Dickey to its growing engineering team. ... the biopharmaceutical cold chain. He provides design and validation engineering services by ...
(Date:3/4/2020)... , ... March 04, 2020 ... ... an industry-leading provider of recombinant antibody products and services, today announced the ... the flexibility to rapidly express a large number of antibodies at 80 ...
(Date:3/3/2020)... ... 03, 2020 , ... Frictionless Solutions, a specialized event services ... recognized by INC. 5,000 on an annual list of America’s fastest growing private ... impacting their spheres of influence and experiencing considerable development. INC. 5,000’s specific list ...
(Date:3/2/2020)... Md. (PRWEB) , ... March 02, 2020 , ... McBee, ... Patent Firms 2019 list in the field of Biotechnology and Organics. , According to ... on a total of 259 patents issued in technology center 1600 during 2019. Technology ...
Breaking Biology Technology: