Navigation Links
OGI invests in drug discovery at InDanio Bioscience
Date:10/19/2010

new therapeutic avenues into the NR family."

InDanio's zebrafish ligand trap (LT) technology and LT drug discovery platform will take advantage of the fact that zebrafish are transparent in early stages of development, thus allowing for the use of fluorescent protein markers. Many drugs never reach the marketplace because they fail toxicology tests or have other unintended effects on the body. Currently, in vitro testing relies on measuring simple chemical interactions to gauge a drug's effectiveness, but this is often not an effective predictor of how drugs will affect living organisms. By beginning the screening process with in vivo assays using live zebrafish, more information on a drug's effectiveness, toxicology and other side-effects can be gathered in advance of and to better inform downstream clinical trials.

"InDanio is in an excellent position to capitalize on the significant work undertaken by the academic and pharma sectors over the past 20 years in characterizing NR proteins and developing compound libraries targeting these proteins," commented Dr. Christian Burks, President and CEO of OGI. "Their screening system should provide novel, productive information on natural ligands, tissue and developmental specificity of natural or xenobiotic compounds, and whether or not a compound binds multiple receptors."


'/>"/>

Contact: Alastair Harris-Cartwright
aharriscartwright@ontariogenomics.ca
416-673-6582
Ontario Genomics Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. JPMorgan Chase & Co., Invests $25,000 to Support Bring Me A Books San Jose Elementary School Library Initiative
2. Finland invests €1.85 million in pan-European infrastructure for biomedical research
3. University of Plymouth invests in dental research
4. NIGMS invests in scientific Grand Opportunities with Recovery Act funds
5. Texas invests record $3.5 million in startup cofounded by UTs Mauro Ferrari
6. T cell discovery shows promise for Type 1 diabetes treatment: UBC-CFRI study
7. Research breakthrough hailed on the anniversary of gene discovery
8. Discovery of a cell that suppresses the immune system
9. Census of Marine Life celebrates decade of discovery
10. Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
11. Biofuel from inedible plant material easier to produce following enzyme discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... New Haven, Conn. – Geologists are letting the air out ... on Earth. , Scientists have long speculated as to why ... Earth,s surface. Animals began to prosper at the end of ... what about the billion-year stretch before that, when most researchers ... seems the air wasn,t so great then, after all. , ...
(Date:10/31/2014)... good for attracting species, but it may not be enough ... study has found. , The researchers surveyed two types of ... abundance of two insects that interact with them. They found ... and black walnut, they didn,t find a corresponding abundance of ... the walnuts and black cherries and a type of wasp ...
(Date:10/31/2014)... Melbourne researchers have uncovered key steps involved in programmed ... diseases including lupus, cancers and neurodegenerative diseases. , ... Institute worked together to discover the three-dimensional structure of ... the first steps in how it causes cell death. ... and Proceedings of the National ...
Breaking Biology News(10 mins):Lack of oxygen delayed the rise of animals on Earth 2Green spaces don't ensure biodiversity in urban areas 2A matter of life and death: Cell death proteins key to fighting disease 2
... Dr. Ron Koder, assistant professor of physics at The City ... devised a novel method for producing an artificial protein capable ... recently awarded a three-year $1.3 million grant from the U.S. ... be administered to injured troops on the battlefield. "Engineered ...
... & Biotechnology News (GEN) recently co-sponsored a roundtable discussion ... in environment clean-up after manmade or natural disasters. "Gulf ... Impact and to Help in Remediation" was also sponsored ... of Massachusetts Boston, where the discussions took place. Part ...
... on hold until after 40, or even 45, will be ... there are associated risks for babies when postponing child-bearing, the ... Aviv University,s Sackler School of Medicine and the Hospital for ... in Israel, a country that supports in vitro fertilization (IVF) ...
Cached Biology News:CCNY professor gets grant to develop 'artificial blood' 2Rocking the cradle after 45 2
(Date:10/31/2014)... Brady (NYSE:BRC), a global ... a new video testimonial on the effectiveness ... a research technician at the BloodCenter of Wisconsin discusses ... and storing hundreds of thousands of samples, and how ... , “At Brady, we design our label materials with ...
(Date:10/31/2014)... 2014  Tavistock Development Co. (TDC), a diversified ... groundbreaking of the GuideWell Innovation Center ... The 92,000-square-foot, three-story facility is the first multi-tenant ... designed specifically for life sciences, health innovation, and ... 650-acre Lake Nona Medical City, near the Sanford-Burnham ...
(Date:10/30/2014)... Investor-Edge has initiated coverage on the following ... (NASDAQ: MDVN ), Pharmacyclics Inc. (NASDAQ: ... and Ironwood Pharmaceuticals Inc. (NASDAQ: IRWD). Free research on ... . On Wednesday, October 29, 2014, the ... Jones Industrial Average declined 0.18%, to finish the day ...
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
Breaking Biology Technology:Brady Debuts New Lab Label Testimonial Video 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 2GuideWell Innovation Center Groundbreaking Hosted by Tavistock Development Company at Lake Nona Medical City 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 2Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 3Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 4Biotech Equities Movers and Shakers - Organovo Holdings, Medivation, Pharmacyclics, Synthetic Biologics, and Ironwood Pharma 5Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3
... second time in six years, a Madison software company ... ,This time Hyperphrase Technologies has filed suit against ... allegedly using technology that provides viewers of a Web ... claims that Google Toolbar features AutoLink and AdSense have ...
... A crowd wearing paper goggles gasped frequently as they ... image sent live from La Crosse to Madison. , , ... 3D with one of the applications he's developed at UW-La ... that could form the foundation for educational software on anatomy. ...
... - With the deployment of Internet Protocol telephony gaining ... have been added to the Wisconsin product line of ... ,With the addition of the Cisco premise-based system, the ... both a hosted and premise-based vendor at a time ...
Cached Biology Technology:Next generation simulations? Not on the Internet you're used to 2Norlight adds Cisco-based IP systems in Wisconsin 2