Navigation Links
OGI invests in drug discovery at InDanio Bioscience
Date:10/19/2010

new therapeutic avenues into the NR family."

InDanio's zebrafish ligand trap (LT) technology and LT drug discovery platform will take advantage of the fact that zebrafish are transparent in early stages of development, thus allowing for the use of fluorescent protein markers. Many drugs never reach the marketplace because they fail toxicology tests or have other unintended effects on the body. Currently, in vitro testing relies on measuring simple chemical interactions to gauge a drug's effectiveness, but this is often not an effective predictor of how drugs will affect living organisms. By beginning the screening process with in vivo assays using live zebrafish, more information on a drug's effectiveness, toxicology and other side-effects can be gathered in advance of and to better inform downstream clinical trials.

"InDanio is in an excellent position to capitalize on the significant work undertaken by the academic and pharma sectors over the past 20 years in characterizing NR proteins and developing compound libraries targeting these proteins," commented Dr. Christian Burks, President and CEO of OGI. "Their screening system should provide novel, productive information on natural ligands, tissue and developmental specificity of natural or xenobiotic compounds, and whether or not a compound binds multiple receptors."


'/>"/>

Contact: Alastair Harris-Cartwright
aharriscartwright@ontariogenomics.ca
416-673-6582
Ontario Genomics Institute
Source:Eurekalert

Page: 1 2

Related biology news :

1. JPMorgan Chase & Co., Invests $25,000 to Support Bring Me A Books San Jose Elementary School Library Initiative
2. Finland invests €1.85 million in pan-European infrastructure for biomedical research
3. University of Plymouth invests in dental research
4. NIGMS invests in scientific Grand Opportunities with Recovery Act funds
5. Texas invests record $3.5 million in startup cofounded by UTs Mauro Ferrari
6. T cell discovery shows promise for Type 1 diabetes treatment: UBC-CFRI study
7. Research breakthrough hailed on the anniversary of gene discovery
8. Discovery of a cell that suppresses the immune system
9. Census of Marine Life celebrates decade of discovery
10. Discovery of key pathway interaction may lead to therapies that aid brain growth and repair
11. Biofuel from inedible plant material easier to produce following enzyme discovery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... considered the most ideal source of nutrition for ... role in the evolution and civilizations of human ... a large number of bacterial species, including some ... no surprise to scientists and physicians. , Indeed, ... be the result of co-evolutionary and co-adaptive interactions ...
(Date:9/2/2014)... A study published in the September 2014 issue ... of Child and Adolescent Psychiatry found that ... had an increased risk of developing diabetes if ... from the nationwide Danish registers, a group of ... Aalborg University Hospital, Denmark, studied 48,299children and adolescents ...
(Date:9/2/2014)... you accidentally touch a hot oven, you rapidly pull ... circuits involved in sensing and responding to such painful ... , Duke researchers have made a surprising discovery about ... in worms, and have built a structural model of ... Nature Communications , may help direct new strategies to ...
Breaking Biology News(10 mins):Are human breast milk microbiome 'neutral'? 2Are human breast milk microbiome 'neutral'? 3Risk of diabetes in children and adolescents exposed to antipsychotics 2Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3
... In order to find out about its migrations, various ... Spain, Argentina and Switzerland have conducted research detailing its ... emerged and it is that the wasps returning to ... genetic micro-evolution which makes them more resistant to their ...
... simple method for reducing the amount of phosphorus in ... called simultaneous precipitation using iron sulphate. A separate treatment ... simultaneously with the actual biological wastewater treatment. ... the biological wastewater treatment process, and the phosphorus dissolved ...
... shapes and scents to attract pollinators has long ... video, researchers have gained intriguing insights into the ... pollinate. The study, published in the British Ecological ... first to measure how much energy hummingbirds use ...
Cached Biology News:Researchers detail the migrations of the wood wasp Sirex noctilio 2Researchers identify a simple way to precipitate phosphorus from the wastewater of a pulp mill 2High-speed video and artificial flowers shed light on mysteries of hummingbird-pollinated flowers 2
(Date:8/29/2014)...  Pfenex Inc. (NYSE MKT: PFNX), a clinical-stage ... and difficult to manufacture proteins including biosimilar therapeutics, ... results for the second quarter ended June 30, ... our initial public offering, we have the capital ... derived from our proprietary protein expression platform," stated ...
(Date:8/29/2014)... 2014 The global companion diagnostics ... 2019. It is expected to grow at a ... was valued at $1.8 billion in 2013, according ... Research. , For more information regarding analysis details ... The research report, titled “Companion Diagnostics Market (Breast ...
(Date:8/29/2014)... Pittcon is pleased to announce that the ... Horiba Scientific, have organized a session on nanotechnology for ... , Asia’s largest analytical and scientific instruments show, will ... , The four speakers in this U.S. symposium, ... to Single Cells” will present their use of nanotechnology ...
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and ... candidates to participate in an investigational study of donor ... goal of this study is to determine if a ... two arthritically affected joints can help reduce pain and ... the current investigational study must be older than nine ...
Breaking Biology Technology:Pfenex Reports Second Quarter 2014 Results and Provides Business Update 2Pfenex Reports Second Quarter 2014 Results and Provides Business Update 3Pfenex Reports Second Quarter 2014 Results and Provides Business Update 4Pfenex Reports Second Quarter 2014 Results and Provides Business Update 5Pfenex Reports Second Quarter 2014 Results and Provides Business Update 6Pfenex Reports Second Quarter 2014 Results and Provides Business Update 7Pfenex Reports Second Quarter 2014 Results and Provides Business Update 8Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 2Companion Diagnostics Market to Hit $5.6 Billion in 2019: Transparency Market Research 3Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... seems like lots of folks are bemoaning the fallen state ... "Dear Abby" bucket. Admit it. You've read at least one ... our relationship it was so exciting. Now we hardly ever ... That's a passably accurate description of how many IT shops ...
... Manufacturing Outreach Center MENOMONIE, Wis. The ... University of Wisconsin-Stout was recently honored by the ... National Institute for Standards and Technology in ... ,The center was ranked number one, with over 450 ...
... , a Midwestern company building cross-platform network adapters and ... announced a free trial of its link aggregation ... IEEE 802.3ad standard , combines multiple Ethernet ports ... individual ports' bandwidth to produce a high-speed data channel ...
Cached Biology Technology:Fred Astaire and Ginger Rogers in the mosh pit 2