Navigation Links
Nutrition influences metabolism through circadian rhythms, UCI study finds
Date:12/19/2013

Irvine, Calif., Dec. 19, 2013 A high-fat diet affects the molecular mechanism controlling the internal body clock that regulates metabolic functions in the liver, UC Irvine scientists have found. Disruption of these circadian rhythms may contribute to metabolic distress ailments, such as diabetes, obesity and high blood pressure.

There's good news, though. The researchers also discovered that returning to a balanced, low-fat diet normalized the rhythms. This study reveals that the circadian clock is able to reprogram itself depending on a diet's nutritional content which could lead to the identification of novel pharmacological targets for controlled diets.

UC Irvine's Paolo Sassone-Corsi, the Donald Bren Professor of Biological Chemistry and one of the world's leading researchers on the genetics of circadian rhythms, led the study, which appears in Cell.

Circadian rhythms of 24 hours govern fundamental physiological functions in virtually all organisms. The circadian clocks are intrinsic time-tracking systems in our bodies that anticipate environmental changes and adapt themselves to the appropriate time of day. Changes to these rhythms can profoundly influence human health. Up to 15 percent of people's genes are regulated by the day-night pattern of circadian rhythms, including those involved with metabolic pathways in the liver.

A high-fat diet reprograms the liver clock through two main mechanisms. One blocks normal cycles by impeding the clock regulator genes called CLOCK:BMAL1. The other initiates a new program of oscillations by activating genes that normally do not oscillate, principally through a factor called PPAR-gamma. Previously implicated in inflammatory responses and the formation of fatty tissue, this factor oscillates with a high-fat diet.

It's noteworthy, Sassone-Corsi said, that this reprogramming takes place independent of the state of obesity; rather, it's solely dependent upon c
'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Page: 1 2

Related biology news :

1. Fish oil added to yogurt may help consumers meet daily nutritional requirements
2. Poll shows strong voter support for school nutrition standards
3. Researchers unveil new assessment for diagnosing malnutrition
4. Carnivorous plants rely on the services and wastes of a symbiotic ant for nutrition
5. Washington University receives $8 million to lead international childhood malnutrition effort
6. Wiley-Blackwell launches new open-access journal: Food Science & Nutrition
7. CRN assesses current state of scientific research for nutritional supplements
8. Nutrition tied to improved sperm DNA quality in older men
9. A mother’s nutrition--before pregnancy--may alter the function of her children’s genes
10. World experts enlist to help Malaysia mitigate problem of poorer nutrition as incomes rise
11. Malaysia to battle nutrition transition problem emerging worldwide: More income, poorer diet choices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2015)...  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... on the growing mobile commerce market and creator ... has filed provisional patent 62/192218 for ... This invention highlights next generation payment technology from ... also the user using unique personal identifiers including ...
(Date:7/9/2015)... SAN JOSE, Calif. , July 9, 2015 /PRNewswire/ ... human interface solutions, announced today that it will report ... 2015 on Thursday, July 30, 2015 after the close ... call for analysts and investors at 2:00 p.m. PT ... information.    To participate on the live ...
(Date:7/8/2015)... NEW YORK , July 8, 2015 ... today announced BD & Guidepoint Mentor, ... free access to Guidepoint,s expert network services. ... developing cutting-edge technologies to improve healthcare delivery and outcomes ... manager, each start-up entrepreneur will be able to directly ...
Breaking Biology News(10 mins):NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 2NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 3NXT-ID Patents Personalized Tokenized Payments for Next Generation Secure Payment Technology 4Synaptics to Report Fourth Quarter, Fiscal Year 2015 Results on July 30 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 2BD and Guidepoint Team to Connect Healthcare Start-up Companies With Business and Scientific Experts 3
... N.C. Researchers at Duke University Medical Center and ... have shown how broken sections of chromosomes can recombine ... "People have discovered high levels of repeated sequences ... theories about why there are so many repeats," said ...
... New Rochelle, NY, August 13, 2008 A ... bringing planetary samples back to Earth for in-depth ... latest issue of Astrobiology, a peer-reviewed ... report is available free online at www.liebertpub.com/ast ...
... in German . Halle/Saale, Potsdam, August ... could lose parts of its current range, a study ... (UFZ), the Potsdam Institute for Climate Impact Research (PIK) ... will be rearranged as a result of climate change; ...
Cached Biology News:Duke-NIEHS team shows how DNA repairs may reshape the genome 2Bringing Martian samples to Earth -- preparations outlined in journal Astrobiology 2Climate change threatens 1 in 5 plant species 2
(Date:7/27/2015)... FRANKLIN, Tenn. , July 27, 2015 ... of health care services and one of the ... announced that its parent company and sole stockholder, ... with Medical Properties Trust, Inc. ("MPT") (NYSE: ... million in cash.  The transaction is expected to be ...
(Date:7/27/2015)... ... July 27, 2015 , ... This is a professional and ... basic overview of the industry including definitions, classifications, applications and industry chain structure. ... competitive landscape analysis, and key regions development status. Development policies and plans are ...
(Date:7/27/2015)... ... July 27, 2015 , ... Brady (NYSE:BRC), a ... 3 Ways to GHS Labels . This video provides useful information on ... (GHS) by effectively labeling chemical containers. , “With the fourth and final deadline ...
(Date:7/27/2015)... 27, 2015 Research presented at the 2015 ... on the studies that led to a fingerprick Ebola ... this disease to receive approval from the World Health ... Ebola,s grip on West Africa ... healthcare workers to isolate and treat these patients much ...
Breaking Biology Technology:Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 2Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 3Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 4Capella Healthcare Announces Agreement With Medical Properties Trust, Inc. 52015 Biophotonics Market Global Research 22015 Biophotonics Market Global Research 3Brady Releases “3 Roads to GHS Labels” Video 2Rapid Ebola Test Could Play Key Role in Efforts to End Lingering Outbreak 2Rapid Ebola Test Could Play Key Role in Efforts to End Lingering Outbreak 3
... VOLC ), a leader in the development, ... of coronary and peripheral artery,disease, said today that it ... Growth Stock Conference on Wednesday, February 18. , ... and chief executive,officer, will begin at 9:30 a.m., Pacific ...
... a Next-Generation Assay to Improve Diagnosis and Treatment of ... (OTC Bulletin Board: VRML), a molecular diagnostics company, today ... a notice of allowance to the Company for the ... The discovery could ultimately lead to the development ...
... a leading private equity investment fund ("JLL") and PharmaNet ... Holdings, LLC ("Parent"), through its wholly-owned subsidiary, PDGI Acquisition ... JLL, has commenced a tender offer for all outstanding ... a price of $5.00 per share net to the ...
Cached Biology Technology:Volcano Corporation Presentation at Roth Capital Partners Conference to Be Webcast 2Vermillion Announces Notice of Issuance of U.S. Patent Covering Hepcidin as a Biomarker for Ovarian Cancer 2Vermillion Announces Notice of Issuance of U.S. Patent Covering Hepcidin as a Biomarker for Ovarian Cancer 3Vermillion Announces Notice of Issuance of U.S. Patent Covering Hepcidin as a Biomarker for Ovarian Cancer 4An Affiliate of JLL Partners, Inc. Commences Cash Tender Offer to Acquire PharmaNet Development Group, Inc. at $5.00 per Share 2An Affiliate of JLL Partners, Inc. Commences Cash Tender Offer to Acquire PharmaNet Development Group, Inc. at $5.00 per Share 3An Affiliate of JLL Partners, Inc. Commences Cash Tender Offer to Acquire PharmaNet Development Group, Inc. at $5.00 per Share 4An Affiliate of JLL Partners, Inc. Commences Cash Tender Offer to Acquire PharmaNet Development Group, Inc. at $5.00 per Share 5An Affiliate of JLL Partners, Inc. Commences Cash Tender Offer to Acquire PharmaNet Development Group, Inc. at $5.00 per Share 6An Affiliate of JLL Partners, Inc. Commences Cash Tender Offer to Acquire PharmaNet Development Group, Inc. at $5.00 per Share 7
Human VEGF R3/Flt-4 Phycoerythrin MAb (Clone 54733)...
Human Legumain Affinity Purified Polyclonal Ab...
Human Cystatin F MAb (Clone 292103)...
... Ac-DEVD-CHO is an ... activity. The concentration of ... caspase activity must be ... system. Ten micromolar inhibitor ...
Biology Products: