Navigation Links
Nutrition influences metabolism through circadian rhythms, UCI study finds
Date:12/19/2013

Irvine, Calif., Dec. 19, 2013 A high-fat diet affects the molecular mechanism controlling the internal body clock that regulates metabolic functions in the liver, UC Irvine scientists have found. Disruption of these circadian rhythms may contribute to metabolic distress ailments, such as diabetes, obesity and high blood pressure.

There's good news, though. The researchers also discovered that returning to a balanced, low-fat diet normalized the rhythms. This study reveals that the circadian clock is able to reprogram itself depending on a diet's nutritional content which could lead to the identification of novel pharmacological targets for controlled diets.

UC Irvine's Paolo Sassone-Corsi, the Donald Bren Professor of Biological Chemistry and one of the world's leading researchers on the genetics of circadian rhythms, led the study, which appears in Cell.

Circadian rhythms of 24 hours govern fundamental physiological functions in virtually all organisms. The circadian clocks are intrinsic time-tracking systems in our bodies that anticipate environmental changes and adapt themselves to the appropriate time of day. Changes to these rhythms can profoundly influence human health. Up to 15 percent of people's genes are regulated by the day-night pattern of circadian rhythms, including those involved with metabolic pathways in the liver.

A high-fat diet reprograms the liver clock through two main mechanisms. One blocks normal cycles by impeding the clock regulator genes called CLOCK:BMAL1. The other initiates a new program of oscillations by activating genes that normally do not oscillate, principally through a factor called PPAR-gamma. Previously implicated in inflammatory responses and the formation of fatty tissue, this factor oscillates with a high-fat diet.

It's noteworthy, Sassone-Corsi said, that this reprogramming takes place independent of the state of obesity; rather, it's solely dependent upon caloric intake showing the remarkable adaptability of the circadian clock.

The authors will extend their research to the effects of a high-fat diet on other body components, including muscle, fat, the brain and blood plasma.


'/>"/>

Contact: Tom Vasich
tmvasich@uci.edu
949-824-6455
University of California - Irvine
Source:Eurekalert

Related biology news :

1. Fish oil added to yogurt may help consumers meet daily nutritional requirements
2. Poll shows strong voter support for school nutrition standards
3. Researchers unveil new assessment for diagnosing malnutrition
4. Carnivorous plants rely on the services and wastes of a symbiotic ant for nutrition
5. Washington University receives $8 million to lead international childhood malnutrition effort
6. Wiley-Blackwell launches new open-access journal: Food Science & Nutrition
7. CRN assesses current state of scientific research for nutritional supplements
8. Nutrition tied to improved sperm DNA quality in older men
9. A mother’s nutrition--before pregnancy--may alter the function of her children’s genes
10. World experts enlist to help Malaysia mitigate problem of poorer nutrition as incomes rise
11. Malaysia to battle nutrition transition problem emerging worldwide: More income, poorer diet choices
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... , March 21, 2017   Neurotechnology , ... recognition technologies, today announced the release of the ... which provides improved facial recognition using up to ... a single computer. The new version uses deep ... accuracy, and it utilizes a Graphing Processing Unit ...
(Date:3/22/2017)... 2017 Vigilant Solutions , a vehicle ... agencies, announced today the appointment of retired FBI special ... safety business development. Mr. Sheridan brings more ... a focus on the aviation transportation sector, to his ... Mr. Sheridan served as the Aviation Liaison Agent Coordinator ...
(Date:3/20/2017)... , March 20, 2017 PMD Healthcare ... personal spirometer and Wellness Management System (WMS), a remote, ... Founded in 2010, PMD Healthcare is a Medical Device, ... a mission dedicated to creating innovative solutions that empower ... With that intent focus, PMD developed the first ever ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... Research and Markets has announced the addition of the ... 2025" report to their offering. ... The Global Agricultural Chelates Market is poised ... decade to reach approximately $825.4 million by 2025. ... the given segments on global as well as regional levels presented ...
(Date:3/29/2017)... 29, 2017 The Global Microfluidic Chips Market ... a specialized and comprehensive study on the existing state of the ... , Europe and Asia-Pacific ... and Africa . ... Browse 172 Tables and Figures, 13 ...
(Date:3/28/2017)... Philadelphia, PA (PRWEB) , ... March 28, 2017 ... ... Johnston, spoke at a Marketing Roundtable on March 22 in Philadelphia. The event ... WHYY. , The Marketing Roundtable featured breakout groups and interaction ...
(Date:3/28/2017)... , March 28, 2017 Volition America, Inc., ... today announced the engagement of Deborah Vollmer Dahlke , ... strategic consultant. Dr. Vollmer Dahlke,s role will be ... in the State of Texas and ... Vollmer Dahlke has significant experience over the past ...
Breaking Biology Technology: