Navigation Links
Novel combination therapy shuts down escape route, killing glioblastoma tumor cells
Date:2/26/2013

t became clear that the glioblastoma cells massively regulated PML enabling them to escape the effects of mTOR inhibitor therapy," reported senior author Paul Mischel, MD, Ludwig Institute member based at the University of California at San Diego.

"Our team hypothesized that if we could use a pharmacological approach to get rid of PML and combine it with an mTOR inhibitor, it could change the response from halting growth to cell death. The question was how?" added Mischel.

Previous research had shown that the use of low-dose arsenic could cause degradation of the PML protein in patients with leukemia. The team hypothesized that if arsenic could degrade PML, it may reverse resistance to mTOR inhibitors. The combination of mTOR and low-dose arsenic in mice indeed showed a synergistic effect, with massive tumor cell death along with very significant shrinkage of the tumor in mice with no ill side effects.

"Current therapy upregulates PML, turning off the mTOR signaling pathway. The tumor cells hide, waiting for the target signal to return," said Mischel. "When low-dose arsenic is added, not only does it stop the cell from returning, it shuts down the escape route killing the tumor cell."

These results present the first clinical evidence that mTOR inhibition promotes PML upregulation in mice and patients, and that it mediates drug resistance. The clinical relevance was confirmed when researchers looked at before- and after-treatment tissue samples from patients treated with mTOR inhibitors, confirming that PML goes up significantly in post treatment of mTOR inhibitors.

"These data suggest a new approach for potential treatment of glioblastoma," said Mischel. "We are moving forward to test that possibility in people."

Post-doctoral students Akio Iwanami and Beatrice Gini from the Mischel lab as well as Ciro Zanca from the Furnari/Cavenee lab, also contributed significantly to this paper.


'/>"/>
Contact: Rachel Steinhardt
rsteinhardt@licr.org
212-450-1582
Ludwig Institute for Cancer Research
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover novel therapy for Crohns disease
2. New clinical trial explores novel noninvasive colon cancer screening test
3. Notre Dame researchers using novel method to combat malaria drug resistance
4. Unique adaptations to a symbiotic lifestyle reveal novel targets for aphid insecticides
5. Key proteins newly discovered form and function may provide novel cancer treatment target
6. Novel discovery by NUS scientists paves the way for more effective treatment of cancers
7. London researchers discover novel mechanism involved in key immune response
8. Mexican rock heroes trial novel green trading system
9. VTT and GE Healthcare developing novel biomarkers to predict Alzheimers disease
10. Cleveland Clinic researchers receive $5 million grant to discover novel pathways to heart disease
11. Novel nano-structures to realize hydrogens energy potential
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... June 17, 2015  Synaptics Inc. (NASDAQ: ... today announced that Xiaomi, one of the world,s ... ClearPad ® family of capacitive touchscreen ... circuits (DDICs) for its latest smartphones, the Xiaomi ... for full in-cell display solutions and DDICs in ...
(Date:6/16/2015)... 2015 Fingerprint Cards (FPC) raises the ... will amount to at least 340 MSEK to that it ... increase in market growth and orders received the revenue guidance ... revenue for 2015 will exceed 1,500 MSEK to an updated ... MSEK. Due to receipt of orders of touch ...
(Date:6/11/2015)... 11, 2015 Daon, a global leader ... its IdentityX Mobile Authentication Platform v4.0 has been ... is an industry consortium launched in 2013 to ... stronger authentication.  In order to receive certification, a ... series of tests that measure compliance and ensure ...
Breaking Biology News(10 mins):Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 2Fingerprint Cards Raises the Revenue Guidance for Q2 2015 and for the Full Year 2015 3Daon's IdentityX Mobile Authentication Platform One of First Products to be Certified by FIDO Alliance 2
... employs RNA, a tiny chemical cousin of DNA, to turn ... nudging a gene awake would help alleviate disease, researchers at ... which is being developed by UT Southwestern scientists, also is ... role that genes play in human health. , ...
... act as a linchpin in the body’s weight-regulating system, playing ... fat storage, sugar use, energy balance and weight, University of ... far too early to say how this protein could be ... obesity, the finding gives scientists an important system to target ...
... than 2,000 samples after researchers at Baylor College of ... chromosomal microarray analysis to look for potential genetic abnormalities ... in detecting abnormalities in individual chromosomes, according to a ... Library of Science ONE. , "Chromosomal microarray analysis is ...
Cached Biology News:Novel laboratory technique nudges genes into activity 2Novel laboratory technique nudges genes into activity 3Major link in brain-obesity puzzle found 2Major link in brain-obesity puzzle found 3Major link in brain-obesity puzzle found 4Chromosomal microarray analysis proves accurate 2
(Date:7/3/2015)... , July 3, 2015 ... for Open Innovation in Science", som finner ... Søknadene sendes på nett, på  http://www.openinnovationinscience.at , ... 2015.  De to største utfordringene ... å undersøke nye forskningsspørsmål og kompleksiteten av ...
(Date:7/2/2015)... ... July 03, 2015 , ... Cuvettes have been used in countless labs for decades. ... find the cuvette they needed. As expected, this was a daunting and tiring process ... part because they were not able to navigate the complex catalog structure. , Now thanks ...
(Date:7/2/2015)... , July 2, 2015 Amici ... Bio-tech procurement company Amici Procurement has chosen Microsoft Cloud ... it move to Office 365.      (Logo: ... small to medium-sized companies in the bio-tech sector with ... of the purchasing cycle to help them obtain best ...
(Date:7/1/2015)... ... July 01, 2015 , ... It is now possible to separate two ... photon emission computed tomography (SPECT) according to researchers from Amen Clinics, UCLA, Thomas ... brain scans and is believed to be the largest brain imaging study ever, will ...
Breaking Biology Technology:Lansering av verdens første Open Innovation-program for utdanning av forskere 2Lansering av verdens første Open Innovation-program for utdanning av forskere 3New Cuvette E-Commerce Website Launched by FireflySci 2Biotech Procurement Company Moves to Office 365 with iomart 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 2Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 3Brain Scans Can Tell Post-Traumatic Stress Disorder and Traumatic Brain Injury Apart According to New Research by Amen Clinics 4
... Calif., March 26 Pharsight,Corporation (Nasdaq: PHST ), ... for optimizing clinical drug,development announced today that it will ... Vegas Investor Conference on April 2, 2008 at the ... William,Frederick, Senior Vice President and CFO, will be presenting ...
... Scientific,Corporation (NYSE: BSX ) today announced the ... at the Society for Cardiovascular Angiography,and Interventions SCAI ... of Cardiology ACC/i2 Summit, which runs from March ... presented at ACC for the TAXUS(R) paclitaxel-eluting,coronary stent ...
... ... and New Zealand, LAVAL, QC, March 25 /PRNewswire-FirstCall/ ... and its commercial,pharmaceutical partner Inovail Pty Ltd ("Inovail"), announce ... Australia and New,Zealand. Neptune foresees this market entry as ...
Cached Biology Technology:Pharsight to Present at B. Riley & Co. 9th Annual Las Vegas Investor Conference 2Boston Scientific Announces Schedule for ACC 2008 2Boston Scientific Announces Schedule for ACC 2008 3Boston Scientific Announces Schedule for ACC 2008 4Boston Scientific Announces Schedule for ACC 2008 5Boston Scientific Announces Schedule for ACC 2008 6Neptune Technologies expands into medicinal markets in Asia Pacific 2Neptune Technologies expands into medicinal markets in Asia Pacific 3
SYBR Green Nucleic Acid Dye...
... TUNEL-based assay kit provides complete components including ... detection of DNA fragmentation in cultured cells ... in the procedure provides greater sensitivity than ... analyzed by flow cytometry. The kit works ...
... Continuous flow of media and other fluid ... lab space, The speed of each individual ... flow set points, are exactly maintained. ... with variable tube types, which allows flow ...
Fujifilm Pictro-Color Process for sharp, clear reproduction comparable to silver-halide photography. Photorealistic 400 dpi quality. A4 and A5 output....
Biology Products: