Navigation Links
Northwestern to expose most deadly infectious diseases in 3-D
Date:10/31/2007

CHICAGO --- A scientist slides on a pair of plastic 3-D glasses and an unearthly blue multi-armed creature -- an image right out of a sci-fi horror flick -- seems to leap out of the computer screen into the laboratory.

But this is no movie director's fantasy. The horror image is real.

The eerie "creature" is from the deadly anthrax bacteria -- specifically one of its proteins. Scientists at Northwestern University's Feinberg School of Medicine are mapping parts of the lethal bacteria in three dimensions, exposing a new and intimate chemical portrait of the biological killer down to its very atoms. This view of the disease will offer scientists who design drugs a fresh opening into the bacterias vulnerabilities, and thus enable them to create drugs to disable it or vaccines to prevent it.

Anthrax is just the beginning. The Feinberg School is directing an ambitious national project that will map a rogues' gallery of 375 proteins from deadly infectious diseases over the next five years. It is being funded by a $31 million contract from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. The payoff could be a wave of new medicines to wipe out some of the worst scourges to ever infect the human race.

"The concept is fairly simple," said Wayne Anderson, who is leading the national project at the Feinberg School's new Center for Structural Genomics of Infectious Diseases. "If you have a lock and a key and you don't know what either one looks like, how will you design them to fit together"" The lock is Anderson's metaphor for the disease; the key is the drug or vaccine that will slip inside its atomic structure and destroy it.

To figure out where to throw the chemical equivalent of a monkey wrench into the anthrax cell -- and others --Anderson will be mapping key proteins the bacteria uses to do its work.

"We'll see what the proteins lo
'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University  
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Penguin chicks exposed to human visitors experience spike in stress hormone
2. Bugs expose underground carbon traffic system 10 times more important than fossil fuel burning
3. Embryos exposed in 3-D
4. Hair samples show babies can be exposed to crystal meth while in the womb
5. Lead-scrubbing drug may also improve muscle function in lead-exposed children
6. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
7. Scientists seek answers on what activates deadly anthrax spores
8. U of M researcher examines newly emerging deadly disease
9. Smart drug targets deadly brain cancer
10. Shark attack worries? Driving to the beach is more deadly
11. Unusual antibiotics show promise against deadly superbugs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Northwestern to expose most deadly infectious diseases in 3-D
(Date:9/18/2014)... cheerful, happy-go-lucky characters, so you might expect that most ... In fact some dogs are distinctly more pessimistic than ... , "This research is exciting because it measures positive ... It offers researchers and dog owners an insight into ... Dr Melissa Starling, from the Faculty of Veterinary Science. ...
(Date:9/18/2014)... Sydney, September 18, 2014 Elsevier, a world-leading ... and services, and the Australasian Research Management Society ... young scientists at the 5th Scopus Young Researcher ... held earlier today at the National Convention Centre ... conference, was attended by guests representing Australia,s and ...
(Date:9/18/2014)... found clownfish larvae can swim up to 400 kilometres in ... cope with environmental change. , Clownfish spend their entire adult ... babies they must wander the open ocean, says study co-author, ... Coral Reef Studies (Coral CoE) at James Cook University. , ... now we,ve been given a rare glimpse into how far ...
Breaking Biology News(10 mins):Dogs can be pessimists too 2Dogs can be pessimists too 3Elsevier and Australasian Research Management Society award scientists at Scopus ceremony 2Nemo's epic journey to find a new home 2
... While Americans generally consume enough protein, they tend ... at lunch, and the largest amount at dinner. ... scientific meeting in Atlanta shows that eating high protein ... compared with a low-protein breakfast (pancakes and syrup) or ...
... their planners or their iPhones keep them organized, when proteins ... more to do with it. New research from postdoctoral fellow ... published in Proceedings of the National Academy of Sciences ... protein keeps people organized on a basic level by promoting ...
... 2013 The world should aim to have vaccines which ... eliminating malaria, licensed by 2030, according to the updated 2013 ... in addition to the original 2006 Roadmap,s goal of having ... form of the disease, for children under 5 years of ...
Cached Biology News:New malaria vaccines roadmap targets next generation products by 2030 2
(Date:9/19/2014)... , Sept. 19, 2014 Pfenex Inc. (NYSE ... development of high-value and difficult to manufacture proteins including ... at the 21 st Annual NewsMakers in the ... . Bertrand Liang , chief executive officer of ... programs and business strategy on Friday, September 26, 2014 ...
(Date:9/19/2014)... 2014 Dublin ... has announced the addition of the  "Micro Market ... their offering.       (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ... the fastest-growing segments in the chromatography market. The ... and expected to reach $2.0 billion by 2019, ...
(Date:9/18/2014)... Austin, TX (PRWEB) September 18, 2014 ... of integrated urological and interventional radiology products and ... (also known as cryotherapy and cryoablation) versus external ... Mid-Atlantic Section of the American Urological Association (MAAUA) ... , "Comparing Relative Effectiveness of Cryosurgery and ...
(Date:9/18/2014)... , Sept. 18, 2014  Health Enhancement Products, Inc. (OTCQB: ... early-stage algae bioactive compounds and metabolic processes, is pleased to ... board of directors. Ms. Nola E. Masterson , a ... joined the board effective September 17, 2014. ... to join our board," states Andrew Dahl , President ...
Breaking Biology Technology:Pfenex to Present at Upcoming Industry Conference on September 26 2Micro Market Monitor : Global Pre-packed Chromatography Columns 2HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2
... OpenClinica at the 2009 ACRP Global Conference & Exhibition, April 24-28 ... ... Denver, CO (PRWEB) April 23, 2009 -- The 2009 Global ... will include presentations and exhibitions on OpenClinica, the world,s leading open ...
... SEATTLE, April 22 Trubion Pharmaceuticals, Inc. (Nasdaq: ... preclinical data regarding its SCORPION(TM) multispecific therapeutic technology ... Association of Cancer Research (AACR) in Denver. The ... of the bispecific CD79BxDR SCORPION molecule, its differentiation ...
... to sustainabilityLAS VEGAS, April 22 Bayer CropScience ... tomorrow today through its sustainability efforts. Today, John ... CropScience, presented Tom Lovelace, United Fresh Produce Association ... the next four years to create the Center ...
Cached Biology Technology:Akaza Research to Present OpenClinica at ACRP Global Conference & Exhibition 2Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting 2Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting 3Trubion Presents Preclinical Data on Its SCORPION(TM) Multispecific Therapeutics at the 2009 American Association of Cancer Research Annual Meeting 4Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 2Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 3Bayer CropScience Donates $1.1 Million to United Fresh Research & Education Foundation to Create the Center for Global Produce Sustainability 4
... Corning CellBIND surface is produced by a ... hydrophilic surface giving more consistent, even cell ... enhances cell attachment and growth uunder difficult ... • CellBIND may provide a more ecominic ...
...
Mouse monoclonal antibody raised against a partial recombinant ARHGEF11. NCBI Entrez Gene ID = ARHGEF11...
... PrecisION Ion Channel Cell Lines ,High ... ,Ion channels are well known for having ... function and consequently have a key function ... that modulate ion channels have been investigated ...
Biology Products: