Navigation Links
No relaxing for cancer cells
Date:6/1/2010

Many tumor cells would not be viable due to aberrant chromosome distribution if they had not developed a special trick. Scientists from the German Cancer Research Center have investigated which genes are responsible for this survival strategy of cancer cells. The revealed that cancer cells rely on the tension of specific protein fibers to be able to multiply. Thus, proteins which maintain this tension are promising targets for new, target-specific anticancer drugs: If they are switched off, cancer cells die.

The two centrosomes of a cell are responsible for cell division to proceed correctly. From these polar bodies in the cytoplasm protein fibers form which correctly distribute the duplicated chromosome set to the newly forming daughter cells. Seen under the microscope, these fibers have the shape of a spindle. Cancer cells, however, often have more than two centrosomes. As a result, their spindle fibers do not necessarily assume the normal shape of a spindle with two poles; instead, they can have a dysfunctional, multipolar shape. Such malformed spindles distribute the chromosomes unevenly among the daughter cells, which are then no longer viable.

Hence, tumor cells only survive if they manage to partition their chromosomes correctly in spite of extra centrosomes. To do so, many cancer cells have developed a special trick: They form clusters of centrosomes. Two clusters are formed per cell and a functioning bipolar spindle can develop between these two. Professor Dr. Alwin Krmer, head of a Clinical Cooperation Unit of DKFZ and Heidelberg University Hospitals has recognized this trick as a previously underrated Achilles' heel of cancer cells, which might be used for destroying them. Jointly with colleagues from DKFZ, Heidelberg University Hospitals, Mannheim Medical Faculty and Mayo Clinic in the U.S., he systematically investigated the question of which genes enable cancer cells to form centrosome clusters and, thus, to escape cell death.
'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. ESF EURYI award winner aims to stop cancer cells reading their own DNA
4. Protein chatter linked to cancer activation
5. Newly created cancer stem cells could aid breast cancer research
6. Western diet linked to increased risk of colon cancer recurrence
7. Obesity and lack of exercise could enhance the risk of pancreatic cancer
8. Low levels of key protein may indicate pancreatic cancer risk
9. Birth records hold pancreatic cancer clue
10. Many parents at-risk for cancer disclose genetic test results to children
11. A new radiation therapy treatment developed for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... 17, 2014 The Parenteral Drug Association (PDA) today ... will speak and at least seven more will participate in ... Omni Shoreham Hotel in Washington D.C. , ... have significant support from the regulatory agencies in ... in our effort to help advance the use of ...
(Date:11/11/2014)...  Forensicon, Inc., a Chicago -based ... the promotion of Yaniv Schiff from Senior ... Schiff,s new role as Director, he will lead company ... examiners and provide leadership within the company,s digital forensics ... Schiff joined Forensicon in 2006 ...
(Date:11/7/2014)... , November 6, 2014 Leading Biometric ... better mobile security revolutionizing online transactions.  Companies in focus today ... Ltd. (NYSE: BABA ), Google Inc. (NASDAQ: ... eBay Inc. (NASDAQ: EBAY ) and MasterCard Inc. ... and NXTDW), a biometric authentication company focused on the ...
Breaking Biology News(10 mins):FDA's Janet Woodcock, EMA's Emer Cooke Headline PDA Quality Metrics Conference 2Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6
... WI, MAY 13, 2010 -- "Food, Nutrition, Agriculture, and ... the title of a book chapter written by key ... of America, and Soil Science Society of America. ... Caron Gala Bijl, Science Policy Programs Coordinator, highlight programs ...
... KNOXVILLE, Tenn. A new commentary on the nature of ... fundamental science research on evolution plays in the understanding of ... a subset of a population shifts onto a novel host, ... new fungal diseases in plants, argue the authors of a ...
... to name the most important problem facing the ... time-honored polling question masks the public,s true concern ... "For years, the wording used in traditional ... public has placed on global warming and the ...
Cached Biology News:Identifying federal research dollars for ag 2Emergence of fungal plant diseases linked to ecological speciation 2Opinion polls underestimate Americans' concern about the environment, Stanford study finds 2Opinion polls underestimate Americans' concern about the environment, Stanford study finds 3
(Date:11/22/2014)... --   , ... KLOX    Mariano Rodriguez ... bestellt    KLOX ist bestens vorbereitet, ... Behandlungssystems zur Wundheilung zu beginnen    , ... erfreut, die folgenden personellen Veränderungen anzukündigen: ...
(Date:11/21/2014)... November 20, 2014 Offering a complete ... Sartorius Entris Balance promotion . The Sartorius Entris Balance ... durable, high accuracy, and easy-to-maintain balance entry level balance. ... It was designed to help customer’s bridge the gap ... balance that is very durable. Sartorius is the second ...
(Date:11/21/2014)... (PRWEB) November 20, 2014 The November ... available as an open access journal featuring the following ... fluorescent proteins to preserve photoresponsiveness in the retina , ... fluorescent in situ hybridization using chromogenic substrates in zebrafish ... DNA, RNA, and protein electrophoresis , Nuclear ...
(Date:11/21/2014)... Texas (PRWEB) November 21, 2014 ... is a professional and in-depth research report on ... including its definition, classification, application, and industry chain ... covers the international market analysis, including China’s domestic ... macroeconomic environment & economic situation analysis. The report ...
Breaking Biology Technology:KLOX Technologies meldet Neubesetzung von Führungspositionen 2KLOX Technologies meldet Neubesetzung von Führungspositionen 3KLOX Technologies meldet Neubesetzung von Führungspositionen 4KLOX Technologies meldet Neubesetzung von Führungspositionen 5Pipette.com Announces an Extension on the Sartorius Entris Balance Promotion to the End of 2014 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 2International Transformer Industry - Analysis on Applications, Development & Forecasts Now Available at ReportsnReports.com 3
... BioSpace, the world,s leading,online bioscience job board community ... biotechnology and pharmaceutical job seekers to the,Pharm Country ... 2008., The 23 bioscience companies recruiting at ... throughout the day. Sean Fitzmorris,Recruiting Manager at Bridgewater-based ...
... Fiapta(TM) (Iloperidone) PDUFA Action July 27, 2008 ... Insomnia Study, ROCKVILLE, Md., Feb. 14 ... company focused on the development,and commercialization of clinical-stage ... financial and operational results,for the fourth quarter and ...
... 14 Sanofi-aventis announced,today that the Chicago Athenaeum ... GOOD DESIGN(TM) Award for the new SoloSTAR(R) disposable,insulin ... type 2 diabetes., "LANTUS(R) SoloSTAR(R) and APIDRA(R) ... development, have been designed in dialogue with,patients, nurses ...
Cached Biology Technology:BioSpace New Jersey Career Fair Attracts Over 1,000 Bioscience Candidates 2Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 2Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 3Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 4Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 5Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 6Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 7Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 8Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 9Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 10Vanda Pharmaceuticals Reports Fourth Quarter and Full Year 2007 Results 11Sanofi-aventis' SoloSTAR(R) Insulin Pen for Lantus and Apidra Receives the Prestigious GOOD DESIGN Award 2Sanofi-aventis' SoloSTAR(R) Insulin Pen for Lantus and Apidra Receives the Prestigious GOOD DESIGN Award 3Sanofi-aventis' SoloSTAR(R) Insulin Pen for Lantus and Apidra Receives the Prestigious GOOD DESIGN Award 4Sanofi-aventis' SoloSTAR(R) Insulin Pen for Lantus and Apidra Receives the Prestigious GOOD DESIGN Award 5
... The pCITE-2a-c(+) vectors are designed for enhanced translation ... extracts, e.g. rabbit reticulocyte lysate. The maps for ... with the following exceptions: pCITE-2b(+) is a 3793 ... BstX I and Xcm I sites. Subtract 7 ...
... White walled plates enhance luminescent signals ... fluorescence,• Not treated (or medium binding) ... and binds biomolecules through passive interactions,• ... of large molecules, such as antibodies, ...
BD Falcon microtest assay plate. 1536 well 12l, black, flat-bottom PS. Polystyrene, nonsterile, no lid. (15/sp, 60/ca) Packaging: 15 / pack, 60 / case ...
... plate washing needs in both the 384-well format ... provides an excellent solution for a variety applications ... Screening or Lead Optimization) and Research. , ... has set a standard for ultra-fast washing in ...
Biology Products: