Navigation Links
No relaxing for cancer cells
Date:6/1/2010

Many tumor cells would not be viable due to aberrant chromosome distribution if they had not developed a special trick. Scientists from the German Cancer Research Center have investigated which genes are responsible for this survival strategy of cancer cells. The revealed that cancer cells rely on the tension of specific protein fibers to be able to multiply. Thus, proteins which maintain this tension are promising targets for new, target-specific anticancer drugs: If they are switched off, cancer cells die.

The two centrosomes of a cell are responsible for cell division to proceed correctly. From these polar bodies in the cytoplasm protein fibers form which correctly distribute the duplicated chromosome set to the newly forming daughter cells. Seen under the microscope, these fibers have the shape of a spindle. Cancer cells, however, often have more than two centrosomes. As a result, their spindle fibers do not necessarily assume the normal shape of a spindle with two poles; instead, they can have a dysfunctional, multipolar shape. Such malformed spindles distribute the chromosomes unevenly among the daughter cells, which are then no longer viable.

Hence, tumor cells only survive if they manage to partition their chromosomes correctly in spite of extra centrosomes. To do so, many cancer cells have developed a special trick: They form clusters of centrosomes. Two clusters are formed per cell and a functioning bipolar spindle can develop between these two. Professor Dr. Alwin Krmer, head of a Clinical Cooperation Unit of DKFZ and Heidelberg University Hospitals has recognized this trick as a previously underrated Achilles' heel of cancer cells, which might be used for destroying them. Jointly with colleagues from DKFZ, Heidelberg University Hospitals, Mannheim Medical Faculty and Mayo Clinic in the U.S., he systematically investigated the question of which genes enable cancer cells to form centrosome clusters and, thus, to escape cell death.
'/>"/>

Contact: Dr. Sibylle Kohlstaedt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Page: 1 2

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. ESF EURYI award winner aims to stop cancer cells reading their own DNA
4. Protein chatter linked to cancer activation
5. Newly created cancer stem cells could aid breast cancer research
6. Western diet linked to increased risk of colon cancer recurrence
7. Obesity and lack of exercise could enhance the risk of pancreatic cancer
8. Low levels of key protein may indicate pancreatic cancer risk
9. Birth records hold pancreatic cancer clue
10. Many parents at-risk for cancer disclose genetic test results to children
11. A new radiation therapy treatment developed for head and neck cancer patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... A new study shows that legume plants regulate ... cytokininssignaling molecules that are transmitted through the plant ... the number of bacteria-holding nodules in the roots. ... the National Institute for Basic Biology, the Graduate ... Center for Sustainable Resource Science in Japan. ...
(Date:9/18/2014)... into the Crimean-Congo hemorrhagic fever virus (CCHFV), a tick-borne ... similar to that caused by Ebolavirus, has identified new ... the potential to lead to novel targets for therapeutic ... reported in a paper published today in the journal ... the Texas Biomedical Research Institute and their colleagues, represents ...
(Date:9/18/2014)... that prompts millions of Americans to undertake jaunts into the ... a little longer within a century, according to new research. ... areas of the United States as summer temperatures linger later ... Global Ecology and Biogeography . For instance, the paper ... tree of New Hampshire could change color one to ...
Breaking Biology News(10 mins):For legume plants, a new route from shoot to root 2Research milestone in CCHF virus could help identify new treatments 2Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... interplay of brain chemicals which help us pay attention in ... By changing the way neurons respond to external stimuli we ... strength of a neuronal response, they can also affect the ... Thiele, Professor of Visual Neuroscience explains: "When you communicate with ...
... can detect molecular variants in chemical mixtures greatly ... important, though time-consuming, processes in analytical chemistry. ... post-doctoral researcher David Patterson, Professor of Physics John Doyle ... Laser Science (CFEL) in Hamburg, Germany developed a system ...
... endanger the whole organism, as they may lead to ... Munich now report how byproducts of respiration cause mispairing ... in our cells controls the form and function of ... this are encoded in the linear sequence of the ...
Cached Biology News:Detecting mirror molecules 2Detecting mirror molecules 3DNA damage: The dark side of respiration 2
(Date:9/18/2014)... D.C. (PRWEB) September 18, 2014 On ... Durbin and Sen. Jim Risch for National Lab Day ... projects from across the national laboratory system. Durbin and ... which aims to increase awareness of the reach of ... technologies and discoveries to address some of our nation's ...
(Date:9/18/2014)... 2014 Research and Markets has ... Industry Report 2014" report to their offering. ... is a professional and in-depth study on the current ... The report provides a basic overview of the industry ... human albumin market analysis is provided for the international ...
(Date:9/18/2014)... -- U.S. biotech company Kultevat has strengthened its ... developed by the Donald Danforth Plant Science Center ... applications in production of natural rubber in Taraxicum ... under the direction of Roger Beachy , Ph.D., ... the Danforth Plant Science Center, and is used to ...
(Date:9/18/2014)... Sept. 18, 2014 /PRNewswire/ - Oncothyreon Inc. (NASDAQ: ... announced concurrent but separate underwritten offerings of 10,000,000 shares ... public of $2.00 per share, for expected gross proceeds ... A Convertible Preferred Stock at a price to the ... of $20 million. Each share of Series A Convertible ...
Breaking Biology Technology:Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3Kultevat obtains license of gene switch technology 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 2Oncothyreon Prices $40 Million Concurrent Public Offerings of Common Stock and Preferred Stock 3
... - Jason Smith acknowledges he's on a personal mission. The ... of the Peak Ridge Capital Group, wants to bridge the gap ... passion for investing in innovative Midwestern technology companies is one of ... in the morning and it is one of the first things ...
... Wis. - Broadlook Technologies , an Internet ... as the firm's chief operations officer. , ,Meier brings ... sectors, and he will be responsible for helping the ... programs. , ,"I believe in Greg, and he believed ...
... Madison, Wis. - A University of Wisconsin-Madison ... return in the nation, according to BusinessWeek 's latest ... class of 2006 paid $186,800 for their MBAs and started ... even in four and a half years, not counting lost ...
Cached Biology Technology:Investor links East Coast funds to Midwest tech 2Investor links East Coast funds to Midwest tech 3UW-Madison MBA program ranked among best for investment return 2
Comp Dim: chamber diam. depth 20 2.8 mm chamber maximum volume 720 μL...
... vitro diagnostic assays, all EIA/RIA plates are ... binding, high optical clarity and low background ... of the Certified Surface Chemistry Programme, which ... QA release specifications. Linkage: This CLS number ...
... Lipid adsorption and clarification reagent; ... the purification of antibodies, proteins, nucleic ... has negligible cross-reactivity, and improves downstream ... a solid-phase, non-ionic adsorbent supplied as ...
... The lyophilization stabilizer is designed to ... and for long-term storage. There ... ingredients. It is a convenient ... 7.2, and is superior to other ...
Biology Products: