Navigation Links
Nice genes! What makes you genetically compatible with your partner?
Date:8/23/2013

A University of Manchester professor and his wife have had their own DNA analysed for compatibility as part of the research for a new book out on 1 October in the US and next week in the UK.

Professor Daniel Davis and his wife Katie's experience is documented in The Compatibility Gene, published by Oxford University Press in the US and Penguin in the UK, which discusses how our crucial compatibility genes may influence finding a life partner as well as our health and individuality.

Professor Davis said: "We each possess a similar set of around 25,000 human genes. Some of our genes vary from person to person, like those that give us a particular eye or hair colour. But my book is about the few genes our compatibility genes that vary the most between each of us. First and foremost these are immune system genes; they control how we combat disease. But recent research shows that they may be even more important than we once thought there is evidence that they can influence how our brains are wired, how attractive we are, even how likely we are to reproduce.''

"I'm used to writing academic papers looking at particular cells and genes but I had to write this book to highlight the wonder of this new research take stock of the big picture - and make this fascinating new science accessible to everyone."

The book explains how research has radically transformed knowledge of the way our bodies work - with profound consequences for medical research and ethics. The story begins with a small band of scientific pioneers who, during the Second World War, struggled to understand the mysteries of transplants and grafts. And continues to the Swiss zoologist who had people rank the sexiness of smells from worn T-shirts - and found the results related to our compatibility genes. Very recent experiments discussed in the book show that these same genes may also influence the likelihood of problems in pregnancy.

Professor Davis, Director of Research at the University of Manchester's Collaborative Centre for Inflammation Research, said finding out more about his and his wife's genetic make-up had been a surprisingly nerve-wracking experience. The couple had their saliva sent to the Anthony Nolan Trust a UK charity that helps match transplantation donors and recipients.

"The tubes were bar- coded and shuffled down a series of robotic instruments that first isolated the DNA and then made copies of our compatibility genes," Professor Davis said. "Small beads, each having a different short piece of DNA attached, were added to a solution containing our genes. Beads with DNA just right to bind to one of our compatibility genes are picked out by a sensor, revealing which versions of these genes we have."

Professor Davis discovered his compatibility genes were quite rare, while his wife's were more common. One group of his genes were frequently found in Europe, particularly Eastern Europe, while the other set were common in India or Australia. His wife found she had a gene which would be helpful if she ever suffered an infection with HIV but which also increased her susceptibility to the auto-immune disease ankylosing spondylitis.

He said: "It's not that any of my individual genes are unusual, but the combination of them is rare because they are usually found in different parts of the world. After being pleased that my genes were quite rare - which according to those smelly T-shirt experiments would mean lots of women would like my scent - I then realised this might not be so useful if I ever needed a transplant. In fact the advice they gave me was: Just don't get ill!"

So does the book reveal the perfect set of genes? Professor Davis concludes: "Overall, nobody has a better or worse set of compatibility genes: there's no hierarchy in the system. The fact that we differ is what's important; the way our species has evolved to survive disease requires us to be different."


'/>"/>

Contact: Alison Barbuti
alison.barbuti@manchester.ac.uk
44-016-127-58383
University of Manchester
Source:Eurekalert

Related biology news :

1. The loss of a protein makes jump the tumor to the lymph node
2. Why spring is blooming marvelous (and climate change makes it earlier)
3. UH makes Princeton Reviews Green List 3 years in a row
4. Modern hybrid corn makes better use of nitrogen, study shows
5. Same gene that stunts infants growth also makes them grow too big
6. Cystic fibrosis makes airways more acidic, reduces bacterial killing
7. Diabetes drug makes brain cells grow
8. UCLA research makes possible rapid assessment of plant drought tolerance
9. Queens University Belfast makes significant cancer breakthrough
10. Waste cooking oil makes bioplastics cheaper
11. Treatment with fungi makes a modern violin sound like a Stradiavarius
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... 2016  The American College of Medical Genetics and Genomics ... as one of the fastest-growing trade shows during the ... Bellagio in Las Vegas . ... growth in each of the following categories: net square feet ... of attendees. The 2015 ACMG Annual Meeting was ranked 23 ...
(Date:6/22/2016)... -- On Monday, the Department of Homeland Security (DHS) ... for the Biometric Exit Program. The Request for Information ... explains that CBP intends to add biometrics to confirm ... States , in order to deter visa overstays, ... Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... , June 20, 2016 Securus ... justice technology solutions for public safety, investigation, corrections ... the prisons involved, it has secured the final ... (DOC) facilities for Managed Access Systems (MAS) installed. ... additional facilities to be installed by October, 2016. ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... Brooklyn, NY (PRWEB) , ... June 24, 2016 , ... ... 15mm, machines such as the Cary 5000 and the 6000i models are higher end ... height is the height of the spectrophotometer’s light beam from the bottom of the ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
(Date:6/23/2016)... 2016  The Biodesign Challenge (BDC), a university competition ... harness living systems and biotechnology, announced its winning teams ... New York City . The ... projects at MoMA,s Celeste Bartos Theater during the daylong ... senior curator of architecture and design, and Suzanne ...
(Date:6/23/2016)... 2016 Apellis Pharmaceuticals, Inc. today announced ... of its complement C3 inhibitor, APL-2. The trials ... dose studies designed to assess the safety, tolerability, ... in healthy adult volunteers. Forty subjects ... single dose (ranging from 45 to 1,440mg) or ...
Breaking Biology Technology: