Navigation Links
Newly identified small-RNA pathway defends genome against the enemy within
Date:3/16/2014

Cold Spring Harbor, NY Reproductive cells, such as an egg and sperm, join to form stem cells that can mature into any tissue type. But how do reproductive cells arise? We humans are born with all of the reproductive cells that we will ever produce. But in plants things are very different. They first generate mature, adult cells and only later "reprogram" some of them to produce eggs and sperm.

For a plant to create reproductive cells, it must first erase a key code, a series of tags attached to DNA across the genome known as epigenetic marks. These marks distinguish active and inactive genes. But the marks serve another critical role. They keep a host of damaging transposons, or "jumping genes," inactive. As the cell wipes away the epigenetic code, it activates transposons, placing the newly formed reproductive cell in great danger of sustaining genetic damage.

Today, researchers at Cold Spring Harbor Laboratory (CSHL) led by Professor and HHMI Investigator Robert Martienssen announce the discovery of a pathway that helps to keep transposons inactive even when the epigenetic code is erased.

"Jumping genes" were first identified more than 50 years ago at CSHL by Nobel-prize winning researcher Barbara McClintock. Subsequent study revealed that jumping genes (or transposable elements) are long, repetitive stretches of DNA. They resemble remnants of ancient viruses that have inserted themselves into their host DNA. When active, transposons copy themselves and jump around in the genome. They can insert themselves right in the middle of genes, thus interrupting them. Scientists have found that more than 50% of the human genome is made up of transposons. Remarkably, in plants, up to 90% of the genome is composed of these repetitive sequences.

When a transposon is activated, it can insert itself within critical genes, disrupting gene function and causing infertility and many diseases. To combat this ever present threat from
'/>"/>

Contact: Jaclyn Jansen
jjansen@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Newly discovered catalyst could lead to the low-cost production of clean methanol
2. Newly discovered marsupial the victim of fatal attraction
3. Newly discovered signaling pathway could impact a variety of autoinflammatory diseases
4. Newly discovered human peptide may become a new treatment for diabetes
5. Attention Vical Incorporated Investors: Vical Misled Investors According to a Newly Filed Class Action
6. Newly identified proteins make promising targets for blocking graft-vs.-host disease
7. UF: Newly discovered tiger shark migration pattern might explain attacks near Hawaii
8. Newly discovered ocean plume could be major source of iron
9. Newly discovered switch plays dual role in memory formation
10. Newly discovered bacterial partnership changes ocean chemistry
11. ACLS Online Renewal Course from United Medical Education Now Features Newly-Updated Course Materials
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Newly identified small-RNA pathway defends genome against the enemy within
(Date:8/10/2015)... , August 10, 2015 ... Eye Tracking Technology for more than two decades, announces ... for integration into all consumer display formats. The SMI ... integration of eye tracking into consumer tablets, laptops, desktop ... smart glasses. Omnivision,s leading sensor technology contributes to the ...
(Date:8/5/2015)... , August 5, 2015 ... & Access Management Market by Software, Services, Vertical (BFSI, Airport, ... & Geography - Global Forecast to 2020", published by ... Management Market globally into various segments. The global PIAM ... 2014 to $546.2 Million by 2019, at a CAGR ...
(Date:8/3/2015)... , Aug. 3, 2015 Synaptics, Inc. ... interface solutions, today announced that members of the executive ... the Pacific Crest Global Technology Leadership Forum on Tuesday, ... conference will be held at the Sonnenalp Resort in ... The presentation may include forward-looking information. An audio webcast ...
Breaking Biology News(10 mins):SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 2Physical Identity and Access Management Market Worth $546.2 Million by 2019 3Physical Identity and Access Management Market Worth $546.2 Million by 2019 4
... in joining the growing number of U.S. regions planning ... innovation clusters. Water clusters build networks of universities, ... development and protection one of the world,s most precious ... for a regional water cluster, the College of Engineering ...
... it takes some fluorescent protein and a tiny microscope implanted ... technique for observing hundreds of neurons firing in the brain ... that activity to long-term information storage. The unprecedented work could ... diseases such as Alzheimer,s. The researchers first used a ...
... be deadly. Thanks to a nearly $2 million grant, a ... will be working to better understand chronic hepatitis E ... the college,s Virginia Tech campus, received the five-year ... lab in the Center for Molecular Medicine and Infectious ...
Cached Biology News:University of Arizona Engineering College pursues water technology innovation cluster 2University of Arizona Engineering College pursues water technology innovation cluster 3University of Arizona Engineering College pursues water technology innovation cluster 4Stanford researchers develop tool for reading the minds of mice 2Virology researcher awarded nearly $2 million to study chronic hepatitis E 2Virology researcher awarded nearly $2 million to study chronic hepatitis E 3
(Date:9/1/2015)... ... September 01, 2015 , ... Industry ... Development, Asia Pacific. In this newly-created position, Gibbs will lead iLab’s business operations ... iLab’s suite of tools. This entails not only introducing iLab to potential partners ...
(Date:8/31/2015)... ... August 31, 2015 , ... The Global Supply Chain ... management and resiliency practitioners with luminaries and thought leaders to advance the professional ... for their innovations and performance excellence. At that time its principle sponsor, ...
(Date:8/31/2015)... Research and Markets ( http://www.researchandmarkets.com/research/k6lcp2/mexico_biomedical ) has ... Market - Growth, Trends & Forecasts (2014-2020)" report ... Biomedical Sensors market is estimated at $0.20 billion by ... 2014-2020 The near future will bring biomedical ... each individual. These sensors can be set to trigger ...
(Date:8/31/2015)... MARLBOROUGH, Mass. , Aug. 31, 2015 /PRNewswire/ ... biotechnology company focused on discovering and developing innovative ... ophthalmology, today announced that the 30-day review period ... Drug (IND) for ocular indications with the U.S. ... the IND is now active. ...
Breaking Biology Technology:iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 2iLab Solutions Hires Gerard Gibbs, Director of Business Development, Asia Pacific 3Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 2Global Supply Chain Resiliency Council Announces Incorporation and Web Site Launch 3Mexico Biomedical Sensors Market Report 2015-2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4
... One temperature cycler can meet the needs of an ... Jason Capodanno ,Michael Steege Michael Rahilly ,Stratagene ... Infinity,temperature cycler, # a new temperature ... readily interchanged without,the use of tools and are currently ...
... Stratagenes custom molecular beacon synthesis assists in detecting SNPs,quickly ... Fei Bao , ... We used Stratagenes custom molecular beacons ... a region of chromosome,10q25.1 and showed clear discrimination among the ...
... the tempest thermoshaker , Jeff Braman ,Stratagene , , ... tempest Thermoshaker , , ... 96-deep-well, round-bottom plate were used to cultivate ... and mid-log phase rates of bacterial growth, ...
Cached Biology Technology:New Temperature Cycler Features Interchangeable Blocks 2New Temperature Cycler Features Interchangeable Blocks 3New Temperature Cycler Features Interchangeable Blocks 4New Temperature Cycler Features Interchangeable Blocks 5Genotyping Single Nucleotide Polymorphisms with Molecular Beacons 2Genotyping Single Nucleotide Polymorphisms with Molecular Beacons 3Genotyping Single Nucleotide Polymorphisms with Molecular Beacons 4Genotyping Single Nucleotide Polymorphisms with Molecular Beacons 5Genotyping Single Nucleotide Polymorphisms with Molecular Beacons 6High-Throughput Cultivation of Bacterial Clones 2High-Throughput Cultivation of Bacterial Clones 3
...
Anti-human L-Ficolin, Clone GN4, Monoclonal Antibody...
Jak3 Antibody Ship: Hot Store: -20 C...
B3GALT2 Immunogen: B3GALT2 (NP_003774, 324 a.a. ~ 423 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Biology Products: