Navigation Links
Newly found protein helps cells build tissues
Date:4/2/2012

PROVIDENCE, R.I. [Brown University] As they work together to form body parts, cells in developing organisms communicate like workers at a construction site. The discovery of a new signaling molecule in flies by Brown University biologists not only helps explain how cells send many long-haul messages, but also provides new clues for researchers who study how human development goes awry, for instance in cases of cleft lip and palate.

For all the diversity of life, animal cells employ only a small set of proteins to send those jobsite signals that coordinate construction. For that reason, said Kristi Wharton, associate professor of molecular biology, cell biology and biochemistry, studying these proteins and pathways in fruit flies can allow biologists and physicians to explain how development and other cellular processes occur in a wide variety of creatures and tissues.

"We are interested in how the pattern of a hand forms or how the pattern of a wing forms," Wharton said. "How do cells know their position in a developing tissue?"

In humans a key family of the signaling molecules that convey such messages are bone morphogenic proteins (BMPs). In fruit flies the directly analagous proteins carry the name "glass-bottom boat" (Gbb), because a mutant form makes larvae appear clear instead of milky white. To date, the conventional wisdom has been that signaling comes from a fly form of BMP known as Gbb15.

"The thought for the longest time is that this smaller protein is the only product that is formed and important for signaling," Wharton said. "But we found another form of this signaling molecule that was not previously known."

Wharton and former postdoctoral fellow Takuya Akiyama introduce the new molecule, Gbb38, in the April 3 edition of the journal Science Signaling. Experiments showed that in tissues where it was abundant, particularly parts of the wing, Gbb38 proved responsible for more signaling activity tha
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Newly-discovered mechanism can explain the Beckwith-Wiedemann syndrome
2. Newly identified gene powerful predictor of colon cancer metastasis
3. Newly found enzymes may play early role in cancer
4. Obesity starts in the head? 6 newly discovered genes for obesity have a neural effect
5. UC Davis research shows that newly discovered drug reduces heart enlargement
6. Newly described contaminant sources in Katrina-flooded homes pose health risks
7. DNA evidence is in, newly discovered species of fish dubbed H. psychedelica
8. Newly discovered gene plays vital role in cancer
9. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
10. Newly discovered reactions from an old drug may lead to new antibiotics
11. Newly discovered snow roots are evolutionary phenomenon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/18/2014)... Nov. 18, 2014  The Secure Identity & ... today jointly announce the formation of The Airport ... its Identity and Biometric Entry and Exit ... received official support from BORDERPOL, the international non-profit ... and provide expertise regarding border security, traveler and ...
(Date:11/18/2014)... 18, 2014   EyeLock Inc. , a ... MorphoTrust USA (Safran), a leading U.S. ... a strategic partnership to offer comprehensive biometric identity ... (MVA), airport screening and financial services markets. ... serves consumers through a nationwide network of 1,100 ...
(Date:11/11/2014)...  Forensicon, Inc., a Chicago -based ... the promotion of Yaniv Schiff from Senior ... Schiff,s new role as Director, he will lead company ... examiners and provide leadership within the company,s digital forensics ... Schiff joined Forensicon in 2006 ...
Breaking Biology News(10 mins):Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 2EyeLock, MorphoTrust Form Strategic Partnership to Pursue Commercial Enterprise Deployments 3Yaniv Schiff Promoted to Director of Digital Forensics at Forensicon, Inc. 2
... calories leads to a longer life, scientists have proved. ... time that such a diet also can maintain physical ... to physical disability and loss of independence. The study, ... that the diet reduces the amount of visceral fat, ...
... to their social behavior, people sometimes act like monkeys, ... monkey that shares with humans strong tendencies for nepotism ... an expert on primate behavior and an Associate Professor ... University of Chicago. After humans, rhesus macaques are ...
... at Case Western Reserve Universitys School of Medicine ... remarkable discovery with a natural product derived from ... a broad set of applications in various joint, ... bowel syndrome., The publication revealed that Progrado, an ...
Cached Biology News:Severely restricted diet linked to physical fitness into old age 2Humans and monkeys share Machiavellian intelligence 2Humans and monkeys share Machiavellian intelligence 3Natural product discovery by Cleveland medical researchers blocks tissue destruction 2
(Date:11/27/2014)... November 26, 2014 Biomedical devices that ... systems to enable 3D manufacture at the micro-nanoscale, and ... are among finalists in nine categories for the ... are sponsored by SPIE, the international society for ... , Winners will be announced by industry leaders on ...
(Date:11/26/2014)... Dallas, Texas (PRWEB) November 26, 2014 ... Bifluoride Industry” is a professional and in-depth research ... Ammonium Bifluoride information, like its definition, classification, application, ... overview. This report covers the international market analysis, ... (such as the US, Europe, Asia, China, Japan ...
(Date:11/26/2014)... YORK , Nov. 26, 2014 The ... may indicate the company is looking to expand in ... further sales.  The healthcare market research firm says that  ... to Kalorama Information,s biennial survey of the IVD market ... and any change in its composition would likely affect ...
(Date:11/26/2014)... On January, 14, 2015, UMBC’s Biotechnology ... science community to the UMBC campus for a discussion ... Protein Society, will take place from 9 a.m. to ... Through discussion, presentations and workshops, the free symposium will ... role in the industry and the future of protein ...
Breaking Biology Technology:Finalists Named for 2015 Prism Awards for Photonics Innovation 2Finalists Named for 2015 Prism Awards for Photonics Innovation 3Finalists Named for 2015 Prism Awards for Photonics Innovation 4Finalists Named for 2015 Prism Awards for Photonics Innovation 5Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 2Ammonium Bifluoride Market International Analysis of Manufacturing, Technology & Trends Now at ReportsnReports.com 3Kalorama: Sale of Three Siemens Healthcare Units Raises Questions About Firm's IVD Future 2
... challenge in the world, and we have to do something ... be attributed to transportation (27 percent), industry (25 percent), and ... U.S. Energy Information Administration statistics published in 2003. ... Fermi Labs . He also said the only way for ...
... operate in the clean technology industry are becoming more attractive ... opportunity to impress the 600 investors that are expected to ... San Francisco. , , Orion Energy Systems of Plymouth ... emerging clean technology companies that will present company overviews during ...
... customer information? Upgrading major software applications? More importantly, ... that you know that technology decisions are being ... are becoming increasingly dependent on information technology (IT) ... just to operate. But for IT to help, ...
Cached Biology Technology:Energy conservation might take us farther than renewable fuels 2Energy conservation might take us farther than renewable fuels 3Energy conservation might take us farther than renewable fuels 4Energy conservation might take us farther than renewable fuels 5Energy conservation might take us farther than renewable fuels 6Are your business and technology goals aligned? 2Are your business and technology goals aligned? 3
...
... Application: Pyronin Y is most widely ... to selectively and differentially stain nucleic ... a dichromatic dye solution, Pyronin Y ... stains DNA green. Chem ...
... kit is designed for the fast and ... plasmids at any position (for the generation ... cassette is designed to allow neomycin / ... It combines a prokaryotic promoter (gb2) for ...
... first instrument to offer true walk-away automation of ... isolate cells by either positive or negative selection, ... samples at one time. RoboSep is easily controlled ... user interface makes it simple and fast to ...
Biology Products: