Navigation Links
New ways to disarm deadly South American hemorrhagic fever viruses
Date:3/8/2010

was working with Boston Children's Hospital virologist Hyeryun Choe when he was co-first author on a report in Nature identifying the human cell surface receptor that the Machupo virus, an arenavirus, grabs to gain access to the human cell it is infecting. The receptor, called transferrin receptor 1, offers a handhold for Machupo virus as it invades cells in the body. Nearly every human cell displays the transferrin receptor, which ferries iron into cells.

Abraham then brought the project to Harrison, who had mentored the young scientist in 2004 as part of HHMI's Exceptional Research Opportunities Program (EXROP), which places undergraduate students from disadvantaged backgrounds in the laboratories of HHMI investigators and HHMI professors. The pairing was fortuitous. In Choe's laboratory, Abraham had developed methods to produce the Machupo virus surface protein, which links to the human transferrin receptor. Meanwhile, Harrison had stocks of purified transferrin receptor because he had previously worked to image the molecule and understood its molecular structure.

Together, the pair made batches of the Machupo surface protein bound to the transferrin receptor and then set about creating an image showing how the two molecules connected. They used x-ray crystallography, a technique in which protein crystals are bombarded with x-ray beams. As the x-rays pass through and bounce off of atoms in the crystal, they produce a diffraction pattern, which can then be analyzed to determine the three-dimensional shape of the protein. After a data collection trip to the powerful x-ray beam at Argonne National Laboratory in Illinois, Abraham and Harrison were able to examine the atomic structure of the Machupo surface protein attached to the transferrin receptor.

The images show that the Machupo surface protein binds to the transferrin receptor in a surprising wayusing a loop called the apical domain. The biological function of this loop in hu
'/>"/>

Contact: Andrea Widener
widenera@hhmi.org
301-215-8807
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists ramp up ability of poplar plants to disarm toxic pollutants
2. Ebola virus disarmed by excising a single gene
3. Disarming specialized stem cells might combat deadly ovarian cancer
4. Scripps research team blocks bacterial communication system to prevent deadly staph infections
5. Northwestern to expose most deadly infectious diseases in 3-D
6. Best treatment identified to reduce deadly Staph infections
7. Research unveils new hope for deadly childhood disease
8. Deadly genetic disease prevented before birth in zebrafish
9. Ayurvedic nightshade deadly for dengue mosquito
10. Sydney harbors deadly diet for sea creatures
11. New vaccine may give long-term defense against deadly bird flu and its variant forms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/2/2015)... 2, 2015  Businesses have a new option ... Tharon Rankins Enterprises has announced the launch of ... way for businesses to protect their customers, personal ... Beconux is a biometric transaction processing ... similarly to an ATM machine, the new system ...
(Date:2/24/2015)... NEW YORK , Feb. 24, 2015 This report ... Thousands by the following Segments: Face Biometrics, and Voice Biometrics. The ... , Japan , Europe ... & Africa , and Latin ... period 2013 through 2020. Also, a seven-year historic analysis is provided ...
(Date:2/18/2015)... 2015  Cepheid (NASDAQ: CPHD ) today announced ... and invited investors to participate via webcast. , Cowen ... Tuesday, March 3, 2015 at 11.20 a.m. Eastern Time ... FL Wednesday, March 4, 2015 at 10.25 a.m. ... live webcasts for these events, please visit Cepheid,s website at ...
Breaking Biology News(10 mins):Personal Data Protection Company Launches New Product 2World Face and Voice Biometrics Industry 2World Face and Voice Biometrics Industry 3World Face and Voice Biometrics Industry 4World Face and Voice Biometrics Industry 5World Face and Voice Biometrics Industry 6World Face and Voice Biometrics Industry 7World Face and Voice Biometrics Industry 8World Face and Voice Biometrics Industry 9World Face and Voice Biometrics Industry 10World Face and Voice Biometrics Industry 11World Face and Voice Biometrics Industry 12World Face and Voice Biometrics Industry 13World Face and Voice Biometrics Industry 14World Face and Voice Biometrics Industry 15World Face and Voice Biometrics Industry 16Cepheid to Webcast Upcoming Financial Presentations 2
... Southampton Centre for Biomedical Research, established by the ... the University of Southampton, have been awarded 17m ... research facilities. The funding, which is ... NHS and university partnerships, has secured the future ...
... Ga. A research team from Rollins College in Florida ... the source of the coral-killing pathogen that causes white pox ... in the Caribbean, elkhorn coral was listed for protection under ... to white pox disease. The team,s findings have just been ...
... fecal material -- in particular, dog fecal material -- may ... Detroit,s wintertime air, says a new University of Colorado Boulder ... four Midwestern cities in the experiment, two cities had significant ... feces being the most likely source. "We found ...
Cached Biology News:Southampton researchers awarded $28 million to progress pioneering nutrition and respiratory research 2Human pathogen killing corals in the Florida Keys 2Human pathogen killing corals in the Florida Keys 3New CU-Boulder study reveals bacteria from dog feces in outdoor air of urbanized air 2New CU-Boulder study reveals bacteria from dog feces in outdoor air of urbanized air 3
(Date:3/3/2015)... SAN DIEGO , March 3, 2015  Halozyme Therapeutics, ... the Barclays 2015 Global Healthcare Conference in Miami, ... ET/10:05 a.m. PT. David A. Ramsay , Chief Financial ... will be webcast through the "Investors" section of Halozyme,s corporate ... made available for 90 days following the event. To access ...
(Date:3/3/2015)... LEXINGTON, Ky. (PRWEB) March 03, 2015 ... aligning their schedules for one event: the Alltech REBELation ... USA, from May 17-20. Now in its 31st year, ... people from 70 countries, and the opportunity to join ... week, March 7 at 11:59 p.m. EST, at which ...
(Date:3/3/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rcv4lq/gene_therapy ... Therapy Market, 2015 - 2025" report to their ... report provides an extensive study on the marketed and ... carried out in this field for over a decade ... in Asian markets; one approved in the EU). There ...
(Date:3/3/2015)... March 3, 2015 /CNW/- SQI Diagnostics Inc. (TSX:V: SQD), ... technologies and products for advanced microarray diagnostics, today ... CFE  to its Management team. In his capacity ... its transition from a development stage to a ... advance the Company,s capital market strategy and to ...
Breaking Biology Technology:Halozyme Therapeutics To Present At The Barclays 2015 Global Healthcare Conference 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 2World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 3World-renowned Leaders, Authors and Businesspeople Join the Alltech REBELation 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 2Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 3Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 4Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 5Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 6Global Gene Therapy Market Report 2015-2025 - Extensive Study on the Marketed and Pipeline Gene Therapies 7SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3
... 8, at approximately 11:26 a.m. EDT, the space shuttle Atlantis ... 39A, for one last mission. While the STS-135 flight marks ... trip may open a new era of research into infectious ... Nickerson, and Roy Curtiss III, along with their colleagues at ...
... Showcasing new tools for widespread development of ... National Institute of Standards and Technology (NIST) have demonstrated ... of an engineered mechanical object down to the quantum ... a Nature paper posted online July 6,* ...
... 2011 ,   ... development and marketing of gene signature-based,diagnostic assays based ... a Research Agreement with Johnson & Johnson,Pharmaceutical Research ... the agreement Skyline,using its proprietary knowledge and technologies ...
Cached Biology Technology:Final countdown: Atlantis to carry next-generation vaccine candidate on last space voyage 2Final countdown: Atlantis to carry next-generation vaccine candidate on last space voyage 3Final countdown: Atlantis to carry next-generation vaccine candidate on last space voyage 4NIST mechanical micro-drum cooled to quantum ground state 2NIST mechanical micro-drum cooled to quantum ground state 3NIST mechanical micro-drum cooled to quantum ground state 4Skyline Diagnostics Establishes Research Collaboration With Janssen 2
MpV17 transgene, murine homolog, glomerulosclerosis...
GEL FILTRATION CAL KIT HMW, 1 EA. *Category: Gel Filtration Gels....
... custom siRNA service provides the premium quality ... research. Custom siRNAs can be readily ordered ... target sequence, or by providing the sense ... Ambion's Silencer Validated and ...
Human FGF R2 (alpha isoforms) MAb (Clone 98706)...
Biology Products: