Navigation Links
New ways to disarm deadly South American hemorrhagic fever viruses
Date:3/8/2010

This release is available in Spanish.

New World hemorrhagic fevers are emerging infectious diseases found in South America that can cause terrible, Ebola-like symptoms. Current treatments are expensive and only partially effective.

Now, Howard Hughes Medical Institute (HHMI) researchers have discovered exactly how one type of New World hemorrhagic fever virus latches onto and infects human cells, offering a much-needed lead toward new treatments.

"New World hemorrhagic fevers are nasty, serious, and often fatal diseases," says Stephen C. Harrison, an HHMI investigator at Harvard Medical School and senior author of the report, published March 7, 2010, in Nature Structural & Molecular Biology. "The need for new interventions is high."

Arenaviruses, the infectious agents that cause New World hemorrhagic fevers, circulate naturally in rodents and can infect people who are in close contact with the animals. Symptoms include severe inflammation and bleeding from the mouth, nose, eyes, and other orifices. Most outbreaks occur in rural regions of Bolivia, Venezuela, Argentina, and Brazil. "The outbreaks of New World hemorrhagic fever tend to be brief and brutal, with mortality rates of 20 to 30 percent," says Jonathan Abraham, an M.D./Ph.D. candidate at Harvard University and first author of the paper. "These viruses aren't a huge public health issue yet, but you could say the New World hemorrhagic fevers are an emerging disease threat."

Researchers have known about these viruses since the 1960s, but the molecular basis of the disease has only been tackled recently, says Abraham, whose graduate studies are funded by HHMI through a Gilliam Fellowship for Advanced Study. The Gilliam Fellowships program currently supports the doctoral education of 30 exceptional students from disadvantaged backgrounds.

In 2007, Abraham
'/>"/>

Contact: Andrea Widener
widenera@hhmi.org
301-215-8807
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Scientists ramp up ability of poplar plants to disarm toxic pollutants
2. Ebola virus disarmed by excising a single gene
3. Disarming specialized stem cells might combat deadly ovarian cancer
4. Scripps research team blocks bacterial communication system to prevent deadly staph infections
5. Northwestern to expose most deadly infectious diseases in 3-D
6. Best treatment identified to reduce deadly Staph infections
7. Research unveils new hope for deadly childhood disease
8. Deadly genetic disease prevented before birth in zebrafish
9. Ayurvedic nightshade deadly for dengue mosquito
10. Sydney harbors deadly diet for sea creatures
11. New vaccine may give long-term defense against deadly bird flu and its variant forms
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... in almost any aquatic environment on Earth, but when ... are pushed to the limit. The amount of time ... for how different species cope in the future, reveals ... Gothenburg, published in the scientific journal Proceedings of ... apace thanks to increasing levels of greenhouse gases in ...
(Date:9/30/2014)... research, involving mice and published in the October 2014 ... , suggests that just because you can do ... team of Italian scientists have found that using marijuana ... immune system. This damage may result in autoimmune diseases ... bowel disease and rheumatoid arthritis in adulthood. , "I ...
(Date:9/30/2014)... with IVF? Here,s some hope: A new research report ... FASEB Journal , explains how scientists developed a ... which induced embryo development in human and mouse eggs ... the sperm cell during fertilization. , "We believe that ... shift in our understanding of human fertilization by providing ...
Breaking Biology News(10 mins):Shape up quickly -- applies to fish, too! 2Adolescent exposure to thc may cause immune systems to go up in smoke 2Synthetic sperm protein raises the chance for successful in vitro fertilization 2
... viruses is also involved in keeping cancer cells alive, researchers ... anti-viral molecule, called TBK-1, was found to be essential for ... a treatment for fighting cancer, the researchers report in today's ... that this mechanism is involved in cancer cell survival, even ...
... to transform into a new life, or into new cells ... in the mechanics - in how a single cell can ... this week in the Proceedings of the National Academy ... human egg. The identification opens the way to understanding these ...
... of different types of nerve cells by neural stem ... much of one kind of cell and too little ... brain malformations. In the October 6 issue of Cell, ... report discovering a new molecular pathway that influences the ...
Cached Biology News:Natural anti-viral enzyme helps keep cancer cells alive, researchers find 2Scientists crack genetic secrets of human egg 2Novel pathway regulates timing of brain cell development 2
(Date:10/1/2014)... Greifensee, Switzerland (PRWEB) October 01, 2014 ... influence the quality of the final product. However, ... most regulated, regulatory frameworks such as Good Manufacturing ... is the responsibility of the manufacturer to interpret ... ensure consistent weighing performance quality. METTLER TOLEDO experts ...
(Date:10/1/2014)... Today the National Institutes of ... for the Brain Research through Advancing Innovative Neurotechnologies ... and revolutionize new methods of understanding the complexities ... This first round of grants totaling $46 million ... to more than 100 investigators in 15 states ...
(Date:10/1/2014)... Francisco, California (PRWEB) October 01, 2014 ... from the National Science Foundation to expand their bioCAD/CAM ... to build and modify DNA. The Small Business Innovation ... commercialize the “j5” technology under exclusive license from the ... Joint BioEnergy Institute , an LBNL laboratory that ...
(Date:9/30/2014)... a well-known optical phenomenon called thin-film interference, a ... the ability to "paint" ultra-thin coatings onto a ... making future, flexible electronic devices, creating advanced solar ... ships and spacecraft with extremely lightweight decorative logos. ... it becomes iridescent, revealing a myriad of colors ...
Breaking Biology Technology:Comply with Weighing-Related Regulations in Pharma Manufacturing 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3TeselaGen Receives $750k NSF SBIR Phase II Award 2TeselaGen Receives $750k NSF SBIR Phase II Award 3Taking thin films to the extreme 2
... 2011 Reaction Biology Corporation ("RBC"), a leading ... epigenetics, today announced the rollout of a new ... initial offerings will emphasize the histone methyltransferases (HMTs), ... no previous commercial source. The ...
... Fla., Oct. 24, 2011 GeneLink BioSciences, Inc. ... leading consumer genomics biotech company, today announced that it ... Deloitte,s ranking of 500 of the fastest growing technology, ... North America. GeneLink grew 4,363 percent during the period ...
... Products, Inc. (NASDAQ: CBPO, "China Biologic" or the "Company"), ... People,s Republic of China, today announced that it has ... "200 Best Under a Billion" for the year 2011. ... for the year 2009. According to Forbes ...
Cached Biology Technology:Reaction Biology Launches Recombinant Methyltransferase Line 2GeneLink BioSciences, Inc. Ranked Number 33 Fastest Growing Company in North America on Deloitte's 2011 Technology Fast 500™ 2GeneLink BioSciences, Inc. Ranked Number 33 Fastest Growing Company in North America on Deloitte's 2011 Technology Fast 500™ 3China Biologic Named to Asia's "200 Best Under a Billion" by Forbes Asia 2China Biologic Named to Asia's "200 Best Under a Billion" by Forbes Asia 3
...
... from vaccinia virus is a type I ... negative superhelical turns (also called right- and ... product of the reaction is a covalently ... negative superhelical turns. DNA Topoisomerase I does ...
Applications include ELISA, immunochemistry, and Western blotting. Working Concentrations: ELISA: 0.005-0.05 U/ml, immunohisto/cytochemistry: 0.25-0.5 U/ml, Western blot: 0.1-0.25 U/ml....
...
Biology Products: