Navigation Links
New type of gene that regulates tumor suppressor PTEN identified
Date:2/24/2013

Researchers at Karolinska Institutet in Sweden have identified a new so-called pseudogene that regulates the tumour-suppressing PTEN gene. They hope that this pseudogene will be able to control PTEN to reverse the tumour process, make the cancer tumour more sensitive to chemotherapy and to prevent the development of resistance. The findings, which are published in the scientific journal Nature Structural and Molecular Biology, can be of significance in the future development of cancer drugs.

The development of tumours coincides with the activation of several cancer genes as well as the inactivation of other tumour-suppressing genes owing to damage to the DNA and to the fact that the cancer cells manage to switch off the transcription of tumour-suppressor genes. To identify what might be regulating this silencing, the researchers studied PTEN, one of the most commonly inactivated tumour-suppressor genes. It has long been believed that the switching-off process is irreversible, but the team has now shown that silenced PTEN genes in tumour cells can be 'rescued' and re-activated by a 'pseudogene', a type of gene that, unlike normal genes, does not encode an entire protein.

"We identified a new non-protein encoding pseudogene, which determines whether the expression of PTEN is to be switched on or off," says research team member Per Johnsson, doctoral student at Karolinska Institutet's Department of Oncology-Pathology. "What makes this case spectacular is that the gene only produces RNA, the protein's template. It is this RNA that, through a sequence of mechanisms, regulates PTEN. Pseudogenes have been known about for many years, but it was thought that they were only junk material."

No less than 98 per cent of human DNA consists of non-protein encoding genes (i.e. pseudogenes), and by studying these formerly neglected genes the researchers have begun to understand that they are very important and can have an effect without encodin
'/>"/>

Contact: The Press Office
pressinfo@ki.se
46-852-486-077
Karolinska Institutet
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study identifies liver gene that regulates cholesterol and fat blood levels
2. Testosterone regulates solo song of tropical birds
3. Zebrafish research shows how dietary fat regulates cholesterol absorption
4. Gut microbiota regulates bile acid metabolism
5. Law that regulates shark fishery is too liberal: UBC study
6. Researchers at IRB Barcelona discover a general mechanism that accelerates tumor development
7. Omega-3s inhibit breast cancer tumor growth, study finds
8. Researchers in Manchester find genetic key to preventing spine tumors
9. Research improving breast cancer treatment by targeting tumor initiating cells
10. Tumor blood vessels prevent the spread of cancer cells
11. Compound stimulates tumor-fighting protein in cancer therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/17/2015)... Aug. 17, 2015  NXT-ID, Inc. (NASDAQ: NXTD ... focused on the growing mobile commerce market and creator ... campaign for Q4 2015. The new marketing campaign is ... of Amplitude Marketing Group ( http://amplitudemarketing.com/ ) and TPMG ... a leader in retail driven marketing and brand awareness ...
(Date:8/12/2015)... , August 12, 2015 ... of mobile payment innovation and advanced biometrics technology is ... the way consumers rely on using their credit cards, ... reinventing the future for payment services led by companies ... NXTD ), :  Google, Inc. (NASDAQ: GOOG ), ...
(Date:8/12/2015)... , Aug. 12, 2015  Synaptics Inc. (NASDAQ: ... interface solutions, today announced that four of its ... solution, have officially been named FIDO Certified™ by ... of the certification, Synaptics, Natural ID™ fingerprint solutions ... Authentication Framework (UAF) standard and are interoperable among ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 2NXT-ID, Inc. Launches Sales Campaign for Wocket Smart Wallet with Award Winning Marketing Team 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3
... it, bread that contains critical nutrients could help combat ... of a group of Johns Hopkins University undergraduate students ... so that it yields beta carotene, the orange substance ... turns into vitamin A. The students, project ...
... likely, you would be disgusted if confronted with a ... worms. Or a particularly bloody wound. Or a horribly ... disgust you feel may lend important insight into your ... scientists closely measured people,s physiological reactions as they looked ...
... -- Low levels of a brain protein that regulates gene ... disorder, a complex and sometimes disabling psychiatric disease. As reported ... journal of The International Society for Bipolar Disorders, levels of ... of the brain in postmortem samples from patients with bipolar ...
Cached Biology News:Students coax yeast cells to add vitamins to bread 2Students coax yeast cells to add vitamins to bread 3Students coax yeast cells to add vitamins to bread 4That's gross!: Study uncovers physiological nature of disgust in politics 2Gene regulatory protein is reduced in bipolar disorder 2Gene regulatory protein is reduced in bipolar disorder 3
(Date:8/31/2015)... DUBLIN , Aug. 31, 2015 Research ... of the "Middle East & Africa Biomedical Sensors ... to their offering. The ... is estimated at $0.84 billion by 2018 at a ... The near future will bring Biomedical sensors that are ...
(Date:8/31/2015)... 2015  RXi Pharmaceuticals Corporation (NASDAQ: RXII ... developing innovative therapies primarily in the areas of ... review period following the filing of the Company,s ... the U.S. Food and Drug Administration (FDA) has ... Logo -  http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
(Date:8/31/2015)... , Aug. 31, 2015 FLX Bio, Inc., ... of novel cancer immunotherapies, announced today that it has ... Executive Officer and William Ho , M.D., Ph.D., ... an experienced management team led by veterans of Flexus ... Ph.D., Chief Scientific Officer; Jay Powers , Ph.D., ...
(Date:8/31/2015)... ... August 31, 2015 , ... Regulatory ... in the drug development approval process. Thus, innovator companies must understand what will ... Inc., a Chicago-based CMO, has been hosting multiple educational panels and seminars for ...
Breaking Biology Technology:Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 2RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 3RXi Pharmaceuticals Announces Advancements in its Ophthalmology Clinical Program with RXI-109 4FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 2FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 3FLX Bio Announces Senior Management Hires and Initiation of Phase 1 Trial of FLX925 4Regis Shares Expert Advice on Impurities in Drug Development 2Regis Shares Expert Advice on Impurities in Drug Development 3
... , SAN DIEGO, Calif., INDIANAPOLIS, Ind., and CAMBRIDGE, ... ), Eli Lilly and Company (NYSE: LLY ) and Alkermes, ... 20 studies at the 45th Annual Meeting of the European Association for ... 29 to Oct. 2. The companies will present the latest research findings ...
... ... million round of funding. Participating investors included CTTV Investments LLC, the venture capital ... , ... Francisco, CA (PRWEB) September 24, 2009 -- LS9, Inc., the Renewable Petroleum Company™, today ...
... , , PHILADELPHIA and LONDON, ... -- researchers likely to be in contention for Nobel honors -- in anticipation ... be announced from October 5-12. , , Thomson Reuters ... Nobel Prize winners. , , Each year, data ...
Cached Biology Technology:Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 2Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 3Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 4Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 5Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 6Amylin and Lilly to Present More than 20 Studies for Exenatide at EASD 2009 7LS9 Secures $25 Million in Latest Round of Funding 2LS9 Secures $25 Million in Latest Round of Funding 3Thomson Reuters Predicts Nobel Laureates 2Thomson Reuters Predicts Nobel Laureates 3Thomson Reuters Predicts Nobel Laureates 4Thomson Reuters Predicts Nobel Laureates 5Thomson Reuters Predicts Nobel Laureates 6
... Complete kit for stabilizing 1.5mg of purified ... optimised for the stabilization of aqueous RNA ... methods such as guanidine, phenol/chloroform, silica, oligo ... StabMRT Kits contain all the necessary components ...
... stabilizing 50g of purified RNA samples for RT-PCR ... all of the advantages and applications you expect ... RNA can be used for enzymatic applications such ... been optimised for the stabilization of aqueous RNA ...
Blasticidin resistance gene (bsr), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
Puromycin resistance gene (pac), provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
Biology Products: