Navigation Links
New type of drug shrinks primary breast cancer tumors significantly in just 6 weeks
Date:4/17/2008

Berlin, Germany: A drug that targets the cell surface receptors that play an important role in many types of cancer can bring about significant tumour regression in breast cancer after only six weeks of use, a scientist told the 6th European Breast Cancer Conference (EBCC-6) today (Thursday 17 April). Dr. Angel Rodriguez, from the Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, USA, said that the work demonstrated for the first time that the tyrosine kinase inhibitor lapatinib could decrease tumour-causing breast cancer stem cells in the primary breast cancers of women receiving neoadjuvant treatment (treatment given before the primary surgery for the disease).

Dr. Rodriguez and colleagues studied 45 patients with locally advanced breast cancer in which the gene HER-2 was over-expressed. The patients received lapatinib for six weeks, followed by a combination of weekly trastuzumab and three-weekly docetaxel, given over 12 weeks, before primary surgery. Biopsies were performed at the time of diagnosis and also after six weeks of lapatinib and cells from the tumours were obtained and analyzed.

We saw significant tumour regression after six weeks of single agent lapatinib, said Dr. Rodriguez. Bi-dimensional tumour measurements showed a median decrease of minus 60.8%. We had previously showed that tumour-causing breast cancer stem cells were resistant to conventional preoperative chemotherapy; indeed, residual cancers that were exposed to such chemotherapy showed an increase in tumour-causing cells and enhanced tumour initiation by the formation of mammospheres, small tumours that form when tumour-causing cells are cultured in a test tube, which reflect the capacity of the cells to self-renew. So we were excited to see that the results with lapatinib were different.

Dr. Rodriguezs results suggest that specific signalling inhibitors of the pathways responsible for stem cell self-renewal could provide a poss
'/>"/>

Contact: Mary Rice
mary@mrcommunication.org
ECCO-the European CanCer Organisation
Source:Eurekalert

Page: 1 2

Related biology news :

1. Single-largest biodiversity survey says primary rainforest is irreplaceable
2. UNH becomes first university in nation to use landfill gas as primary energy source
3. New chemotherapy combo produces side effects, but no extra efficacy, in early breast cancer patients
4. Standard chemo works better against metastatic BRCA1/2 breast cancer than against sporadic tumors
5. Pregnant patients lose out in breast cancer treatment; a new approach is needed
6. Improving care and knowledge in translational research to fight breast cancer
7. Evidence now suggests eating soy foods in puberty protects against breast cancer
8. T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role
9. MU researcher links hormone replacement therapy to breast cancer
10. Gene variant increases breast cancer risk
11. High levels of estrogen associated with breast cancer recurrence
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... USA One of the most diverse families in ... Lucinidae (or lucinids) -- originated more than 400 million ... life habits like those of its modern members. This ... University of Hawaii, published online on 25 July 2014, ... significant symbiotic relationships. , At is origin, the Lucinidae ...
(Date:8/1/2014)... a more effective way to control the condition, thanks ... National University of Singapore (NUS). , The team, led ... Pharmacology at the NUS Yong Loo Lin School of ... PhD graduate from the Saw Swee Hock School of ... herbal-based anti-malarial drug, can be used to control asthma, ...
(Date:8/1/2014)... study, including two Simon Fraser University research associates, ... policymakers must collaborate closely on minimizing damage to ... Popescu and Maureen Ryan, David H. Smith Conservation ... among eight international co-authors of the newly published ... Environment . , Shale gas development is the ...
Breaking Biology News(10 mins):Symbiotic survival 2Symbiotic survival 3Symbiotic survival 4Symbiotic survival 5Symbiotic survival 6Symbiotic survival 7Symbiotic survival 8Symbiotic survival 9Symbiotic survival 10Symbiotic survival 11Symbiotic survival 12Symbiotic survival 13Symbiotic survival 14NUS study shows effectiveness of common anti-malarial drug in controlling asthma 2Scientists warn time to stop drilling in the dark 2Scientists warn time to stop drilling in the dark 3
... where and how some plant seeds store iron, a valuable ... plants. Their research helps address the worldwide problem of iron ... iron is stored in the developing vascular system of the ... particular, iron is stored in the vacuole, a plant cell's ...
... evaluated improvements in the end-of-life care in intensive care ... special supplement to Critical Care Medicine, the journal of ... dedicated entirely to end-of-life care in the critical care ... critically ill and dying patients in the ICU remains ...
... factor known to be important for the survival of ... motor neurons ?critical brain cells that connect the cerebral ... motor neuron diseases like amyotrophic lateral sclerosis (ALS or ... of Nature Neuroscience, two investigators from Massachusetts General Hospital ...
Cached Biology News:Plant studies reveal how, where seeds store iron 2End-of-life care can be improved 2End-of-life care can be improved 3Growth factor stimulates rapid extension of key motor neurons in brain 2
(Date:8/1/2014)... AACC, a global scientific and medical professional ... an updated brand identity today that reflects the organization,s ... healthcare environment and continue to do what they do ... the care they need. " The ... essential role in saving lives and making people healthier," ...
(Date:8/1/2014)... 2014 Once a decision has been ... webinar will discuss how to define your tolerance for ... Bob Allen, Senior Director of Facilities Integration at Fluor ... Fluor Industrial Services, and special guest Carrier Li, Director ... Amgen, as they provide an examination of the Conceptual ...
(Date:7/31/2014)... (PRWEB) July 31, 2014 Food ... are increasingly searching for food alternatives that offer ... benefits. The food ingredient market has numerous players ... such as Vital Force Technology (VFT). VFT ... than 4,000 energetic patterns, all tested to produce ...
(Date:7/31/2014)... Alan Turing, the British mathematician (1912-1954), is famous for ... the 20th century. In 1936 he published a paper, ... first formal concept of a computer algorithm. He next ... designing the machines which cracked the German military codes, ... crucial battles. And in the late 1940,s he turned ...
Breaking Biology Technology:AACC Debuts Refreshed Brand Identity 2Defining Low Cost in Your Solution for Future Facilities, New Webinar for Pharma, Biotech, Medical Device and Healthcare Companies, Hosted by Xtalks 2Functional Ingredient Manufacturer – Vital Force Technology Infuses Raw Materials & Ingredients with Subtle Energy Formula 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 2A mathematical theory proposed by Alan Turing in 1952 can explain the formation of fingers 3
... awards recognize outstanding journalism demonstrating the essential role ... , , ... 16 The Foundation for Biomedical Research (FBR) today announces the ... named in honor of FBR,s late chairman Dr. Michael E. DeBakey ...
... , AKRON, Ohio , June 16 On Wednesday, ... Ohio promises to inspire renewed hope for new jobs in ... coatings industries will share their insight on innovation, global commerce and the new ... at www.ohio.com/jobgrowth . , , ...
... and SAN DIEGO , June 16 ... Biosciences, Inc. (Nasdaq: NBIX ) today announced that ... and commercialize elagolix for the treatment of endometriosis-related pain. ... antagonist, which has recently completed a phase IIb study ...
Cached Biology Technology:2010 Michael E. DeBakey Journalism Awards Announced 2Free Web Cast On Fueling Ohio's New Job Growth 2Abbott and Neurocrine Announce Global Agreement to Develop and Commercialize Elagolix for the Treatment of Endometriosis 2Abbott and Neurocrine Announce Global Agreement to Develop and Commercialize Elagolix for the Treatment of Endometriosis 3Abbott and Neurocrine Announce Global Agreement to Develop and Commercialize Elagolix for the Treatment of Endometriosis 4Abbott and Neurocrine Announce Global Agreement to Develop and Commercialize Elagolix for the Treatment of Endometriosis 5
DDO Immunogen: DDO (NP_003640, 270 a.a. ~ 370 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
... Immunogen: Goats were immunized ... Antibody was isolated by affinity chromatography using ... anti- human T7 affinity purified antibodies were ... method. Specificity: Antibody ...
Recognizes the VZV nucleocapsid by indirect immunofluorescence and immunoprecipitation. Shows cross-reactivity to HSV....
Duck polyclonal to Cobra venom - Fab Fragment ( Abpromise for all tested applications). Antigen: Snake Venom of N. naja arta...
Biology Products: