Navigation Links
New treatment boosts bone healing and regrowth

BIRMINGHAM, Ala. A drug originally used to treat iron poisoning can significantly boost the bodys own ability to heal and re-grow injured bones, according to researchers at the University of Alabama at Birmingham (UAB).

The researchers injected the drug deferoxamine (DF), which is designed to reduce iron overload, into injured mouse bones. They found DF triggered the growth of new blood vessels, which in turn kicked off bone re-growth and healing.

In the study, bone density surrounding the injury more than doubled to 2.6 cubic millimeters in treated bones compared to 1.2 cubic millimeters in untreated bones, the researchers said. The new blood vessel growth and bone healing was achieved through a cell pathway that helps the body respond to low oxygen levels, a common problem when blood supply is affected by bone fracture and disease.

Findings on this cell pathway have broad implications for improving treatment of bone fractures, bone disease and other musculoskeletal disorders, said Shawn Gilbert, M.D., an assistant professor of orthopedic surgery in the UAB School of

Medicine, and Chao Wan, M.D. Ph.D., an instructor in the UAB Department of Pathology, both co-authors on the study.

With DF activating this pathway, weve proven a significant point it is possible to explore new, safe and more affordable ways kick-start bone repair, Gilbert said.

Current treatments use complex proteins, which are expensive to make and cost thousands of dollars per dose. The type of agent used in this study is a simple, small molecule drug that costs hundreds, not thousands, Gilbert said.

The UAB findings are published in the online version of the journal Proceedings of the National Academy of Sciences and will soon appear in a print edition.

The results from this study are a milestone for future studies looking at other compounds and agents to improve new-blood-vessel growth in skeletal and other tissues that need adequate blood supply to regenerate, Wan said.

The UAB tests were performed in conjunction with a bone lengthening procedure commonly used in children and adults, and has proven to aid bone healing. The study mice were anesthetized for surgery, and one leg bone was cut clean through and a pulling device attached temporarily to stretch the bone gap for the next 10 days.

During the stretching, the bone gap was injected with five DF doses. Two weeks after the last DF dose, X-rays of the mice legs were taken to measure bone regeneration.

DF is a drug that binds to excess iron in the body and helps with excretion through the bowels and bladder, a process sometimes called iron chelation. DF is used to treat a variety of medical conditions, including iron overload, transfusion-related blood poisoning and in combination with dialysis.

In the findings on post-treatment increased bone density, the UAB researchers found significant increases in the number of new blood vessels, and excellent connectivity between those vessels. The new blood vessels are required regenerate bone of equal or better strength than the original bones.

Gilbert said it follows that this cell pathway is a prime target for future human studies using DF and other drugs to strengthen the bodys bone-healing potential, especially since poor blood supply is common in fractures and bone disease.


Contact: Troy Goodman
University of Alabama at Birmingham

Related biology news :

1. Nicotinic receptors may be important targets for treatment of multiple addictions
2. A new radiation therapy treatment developed for head and neck cancer patients
3. Restoring sight, advances in fertility treatments and better visibility for pilots at FIO
4. Presence of gene mutation helps guide thyroid cancer treatment
5. U of M begins nations first clinical trial using T-reg cells from cord blood in leukemia treatment
6. New genetic research into nicotine addiction shows promise for personalized treatment
7. Interleukin-8, key marker for colorectal cancer treatment
8. New class of drug offers hope to treatment-resistant AIDS patients
9. Paradigm shift in Alzheimerss research: new treatments
10. New research on structure of bones raises questions for treatment of osteoporosis
11. Major genetic breakthrough for ankylosing spondylitis brings treatment hope
Post Your Comments:
(Date:10/29/2015)... Today, LifeBEAM , a leader ... a global leader in technical performance sports clothing ... advanced bio-sensing technology. The hat will allow fitness ... biometrics to improve overall training performance. As a ... bring together the most advanced technology, extensive understanding ...
(Date:10/27/2015)... 27, 2015 Munich, Germany ... Mapping technology (ASGM) automatically maps data from mobile eye ... , so that they can be quantitatively analyzed ... Munich, Germany , October 28-29, 2015. SMI,s ... from mobile eye tracking videos created with SMI,s ...
(Date:10/26/2015)... , October 26, 2015 ... --> adds Biometrics Market ... 2021 as well as Emerging Biometrics ... reports to its collection of IT ... . --> ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Israel , Nov. 24, 2015  Tikcro Technologies Ltd. (OTCQB: TIKRF) ... on December 29, 2015 at 11:00 a.m. Israel ... Electra Tower, 98 Yigal Allon Street, 36 th Floor, ... of Eric Paneth and Izhak Tamir to the ... Rami Skaliter as external directors; , approval of an amendment to ...
(Date:11/24/2015)... , Nov. 24, 2015  Twist Bioscience, ... that Emily Leproust, Ph.D., Twist Bioscience chief executive ... Healthcare Conference on December 1, 2015 at 3:10 ... in New York City. --> ... . Twist Bioscience is on Twitter. Sign ...
(Date:11/24/2015)... ... , ... InSphero AG, the leading supplier of easy-to-use solutions for production, culture, ... serve as Chief Operating Officer. , Having joined InSphero in November 2013 ... was promoted to Head of InSphero Diagnostics in 2014. There she has built ...
(Date:11/24/2015)... Nov. 24, 2015 /CNW Telbec/ - ProMetic Life Sciences Inc. ... that Mr. Pierre Laurin , President and Chief Executive ... the upcoming Piper Jaffray 27 th Annual Healthcare Conference ... December 1-2, 2015. st , at 8.50am ... meetings throughout the day. The presentation will be available live ...
Breaking Biology Technology: