Navigation Links
New tool for mining bacterial genome for novel drugs
Date:1/25/2013

Vanderbilt biochemists have discovered that the process bacteria undergo when they become drug resistant can act as a powerful tool for drug discovery.

Their findings reported this week in the Online Early Edition of the Proceedings of the National Academy of Sciences should give a major boost to natural products drug discovery the process of finding new drugs from compounds isolated from living organisms by substantially increasing the number of novel compounds that scientists can extract from individual microorganisms.

Bacteria have traditionally been the source of important drugs such as antibiotics and anticancer agents. Researchers looking for new bacterially synthesized drugs have long known that bacterial genomes contain a large number of "silent genes" that contain the instructions for making drug-like compounds. But, until now, scientists have found it is very difficult to find ways to turn on the production of these compounds, known as secondary metabolites.

While investigating how bacteria develop drug resistance, Vanderbilt biochemists Brian Bachmann and John McLean discovered that strains of antibiotic-resistant bacteria express hundreds of compounds not produced by their progenitors, many of which are potential secondary metabolites.

"It's as if the bacteria respond to the assault by the antibiotic with a 'save-all-ships' strategy of turning on hundreds of silent genes," said Bachmann, associate professor chemistry at Vanderbilt.

"This technique is something like fracking in the natural gas industry. We've known for a long time that there were large amounts of underground natural gas that we couldn't extract using conventional methods but now we can, using hydraulic fracturing technology. In a similar fashion we think we can use bacteria's antibiotic resistance to intensively mine the bacterial genome for new drug leads," he said.

The original purpose of the study was to take the most det
'/>"/>

Contact: David Salisbury
david.salisbury@vanderbilt.edu
615-343-6803
Vanderbilt University
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Supplements and cows milk play biggest roles in determining vitamin D levels in children
2. Mining ancient ores for clues to early life
3. Minimizing mining damage with manure
4. Mining cleanup benefits from Texas A&M expertise
5. Study: Odd biochemistry yields lethal bacterial protein
6. Antibacterial agent used in common soaps found in increasing amounts in freshwater lakes
7. Stopping smoking reduces risk of bacterial pneumonia in people with HIV
8. Study quantifies the size of holes antibacterials create in cell walls to kill bacteria
9. RIT scientists decode 3 bacterial strains common to grapevines and sugarcane
10. OU study suggests the bacterial ecology that lives on humans has changed in the last 100 years
11. New edition of Bacterial Genetics text available
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/5/2014)... Santamaria, associate professor of biology in the UTSA ... in the nation selected to receive a two-year ... for Exploratory Research (EAGER). The funding supports President ... researchers to create new technology that will demystify ... complex behaviors in neuroscience are broken into the ...
(Date:11/4/2014)... of death at the right time might actually help ... that could help in understanding animal populations, pest control ... paper in the journal Trends in Ecology and ... conclude that the kind of positive population effect an ... mortality, depends on the size and developmental stage of ...
(Date:11/4/2014)... 2014   3D ... Fuel3D , a developer of 3D scanning ... totaling $6.4 million (£4 million). This funding builds on the ... year and paves the way for the commercial launch of ... funding round was led by Chimera Partners and will be ...
Breaking Biology News(10 mins):UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3When less is more: Death in moderation boosts population density in nature 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3
... (Santa Barbara, Calif.) The Earth is in the midst ... with nearly 50 percent of all species disappearing, scientists say. ... Barbara are working day and night to determine which species ... flowering plants, is published this week in the Proceedings ...
... when they stumbled on small sugar molecules lurking in the ... be there, but they certainly weren,t supposed to be repeatedly ... and off. The conventional wisdom was that the job ... their actions -- fell to phosphates, in a common ...
... Louis, Oct.20, 2008 Researchers have shown that self-induced breaks ... genes that cause the cells to travel from where they,re ... Scientists have known for two decades or more that ... splits in both of the two strands. However, the new ...
Cached Biology News:Current mass extinction spurs major study of which plants to save 2Current mass extinction spurs major study of which plants to save 3Johns Hopkins researchers detect sweet cacophony while listening to cellular cross-talk 2Seemingly suicidal stunt is normal rite of passage for immune cells 2Seemingly suicidal stunt is normal rite of passage for immune cells 3
(Date:11/21/2014)... (PRWEB) November 20, 2014 The ... public policy research organization representing leading California academic ... and PwC US today released a ... life sciences industry growth. The trend shows a ... 2015 California Biomedical Industry Report indicates ...
(Date:11/21/2014)... Dallas, Texas (PRWEB) November 21, 2014 ... China Sodium Ferrocyanide Industry” is a professional and ... it provides Sodium ferrocyanide information, like its ... well as industry overview. This report covers the ... well as global (such as the US, Europe, ...
(Date:11/21/2014)... GUELPH, ON , Nov. 20, 2014 /PRNewswire/ - BIOREM Inc. (TSXV: ... month and nine month periods ended September 30, 2014.  Biorem,s complete ... SEDAR ( www.sedar.com ). Financial Summary:Three-months ended ... CDN$,000 except per share data) , 2014 , ... , 2,282 , 5,281 , 6,715 ...
(Date:11/18/2014)... (PRWEB) November 17, 2014 Athena Signature Series: ... , Dr. Beverly Emerson, a professor in the Regulatory Biology ... Her most recent discovery points to an “off switch” for ... career and how her local research is making a global ... her findings and then join host Cheryl K. Goodman, CEO ...
Breaking Biology Technology:California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 2California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 3California Healthcare Institute and PwC Report Boom in California’s Biomedical Industry 4Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 2Sodium Ferrocyanide Market: Analysis for Global & China Regions Development Trends Available at DeepResearchReports.com 3Biorem Reports Third Quarter Results 2Biorem Reports Third Quarter Results 3
... mothers are being pooled to place ads on their round, ... this is how news is created. To some, this is ... a process that ensures a top spot on the list ... There is no limit to these weird processes. , ,Roy ...
... Healthcare reported Monday that it has signed a ... System to develop new, minimally invasive surgery techniques. ... Healthcare's surgical navigation tools, the InstaTrak 3500 Plus and ... therapeutic and surgical intervention for the brain and spine. ...
... company that uses Medical College of Wisconsin technologies and ... for development of diagnostics for sepsis and pneumonia. , ... grant, which will come over the next five years, ... miniaturize those methods, and demonstrate the performance of this ...
Cached Biology Technology:A final word on branding 2A final word on branding 3A final word on branding 4A final word on branding 5
XA7 B6...
... MEGAscript RNAi Kit is optimized ... mass amounts of ready-to-use dsRNA ... systems. The MEGAscript RNAi Kit ... high-yield transcription technol-ogy and includes ...
... as building blocks, Parker can create ... solutions that are ideal for pick-and-place ... ,system, Parker can also integrate pneumatic ... and ,guarding., Standard or custom ...
... the smallest electronic pressure controller available measuring ... configured this unit specifically for the analytical ... in carrier gas flow control, microfluidic flow ... hydro-dynamic focusing, the OEM-EPC offers external pressure ...
Biology Products: