Navigation Links
New telemetry implants expected to change how large animal toxicology studies are conducted
Date:12/11/2014

ST. PAUL, Minn., Dec. 10, 2014 /PRNewswire/ -- Data Sciences International (DSI), the global leader in wireless physiologic monitoring, has released a new series of digital telemetry implants to meet the changing needs of preclinical toxicology researchers. M series, part of the PhysioTel™ Digital platform, was designed to help toxicologists collect the best possible physiologic data when incorporating functional endpoints into repeat-dose toxicology studies.

Adding functional endpoints to toxicology studies has evolved from short ECG strips from restrained animals to external telemetry, to now a growing acceptance of implantable telemetry. M series implants can collect blood pressure, ECG, temperature, and activity for hours, days, or weeks in unrestrained animals while avoiding confounding artifacts that could affect the detection and interpretation of study-related pathology endpoints.

Recent cardiovascular studies1, 2 have shown that housing and monitoring multiple animals in a single enclosure reduced animal stress, resulting in decreased resting blood pressure and heart rate. The combination of normalized baseline values and cleaner digital signals yielded more precise data on the functional drug effects being examined.

"This newest iteration of DSI's breakthrough PhysioTel Digital telemetry platform will provide a dramatic step forward in the researcher's ability to collect high-quality physiologic signals from unrestrained, conscious experimental animals in a low-stress environment," said R. Dustan Sarazan, DVM, Ph. D., Chief Scientific Officer of DSI.

PhysioTel Digital also offers significant labor savings compared to other collection methods. The system eliminates the need to train and jacket animals. It also reduces animal handling, equipment maintenance and data analysis time due to decreased data variability.

Because M series implants are small, low-cost, and have built-in traceability features, they are also expected to have applications in infectious disease research, basic research, vaccine development and drug discovery.

"I believe that the improvements in scientific rigor, animal welfare (reduction and refinement), and clinically translatable physiologic data provided by this new system will quickly make competing technologies as obsolete as the dial telephone," said Sarazan.

ABOUT DSI

DSI is a pioneering biomedical research company focused on preclinical systems physiology and pharmacology. The recognized global leader in physiologic monitoring, DSI offers telemetry, pulmonary solutions, software and services that help advance science. DSI serves many industries including: Pharmaceuticals, Academia, Contract Research Organizations, Biological and Chemical Defense, the Medical Device Industry, Government, and Biotechnology companies. Solutions are tailored specifically to meet the unique research needs of its customers. 

Visit http://www.datasci.com for more about the company.

1 Kreckler, L.M., Grosh, J., Schneider, J. & Foley, C.M. (2014, March). "Assessment of ECG and Hemodynamic   Changes in Nonhuman Primates Given Four Reference Compounds in Pen or Individual Housing." Poster session presented at the Society of Toxicology Meeting and ToxExpo™, Phoenix, AZ.

2 Stutler, S.A. & Cox, D.M. (2012). "Use of novel telemetry devices to collect individually discernible data sets from socially housed rhesus macaques (Macaca mulatta)." International Journal of Toxicology, 32 (1) 71.

Contact: Nancy Linden, nlinden@datasci.com, 651-414-5454


'/>"/>
SOURCE Data Sciences International
Copyright©2014 PR Newswire.
All rights reserved

Related biology news :

1. Louisiana Tech University researchers use 3D printers to create custom medical implants
2. Bioengineer receives $2.9 million grant to improve brain implants
3. New gel to promote bone growth on implants used in surgical procedures
4. Silk-based surgical implants could offer a better way to repair broken bones
5. Cochlear implants -- with no exterior hardware
6. Study finds natural compound can be used for 3-D printing of medical implants
7. New research association started: Magnesium implants shall facilitate bone fracture healing
8. Non-slip tracheal implants
9. Scientists sniff out unexpected role for stem cells in the brain
10. An unexpected bonus
11. Scientists discover RNA modifications in some unexpected places
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2019)... ... September 30, 2019 , ... USDM Life ... of life science organizations to accelerate innovation and maximize productivity, announces that David ... , What: Just 30 days to 21 CFR Part 11 compliance with Box, ...
(Date:9/25/2019)... ... 2019 , ... The esteemed dental implant specialists at DIA ... a variety of procedures, including single tooth replacement, new “teeth-in-a-day” immediately functioning dental ... offer patients permanent tooth replacement solutions that look and function very similar ...
(Date:9/24/2019)... ... September 23, 2019 , ... Global molecular diagnostics company ... Holotype HLA and other Omixon products will be featured among 10 posters and ... Histocompatibility and Immunogenetics (ASHI) in Pittsburgh, PA. Omixon’s Lunch Symposium on Thursday ...
Breaking Biology News(10 mins):
(Date:9/24/2019)... ... 24, 2019 , ... Drug resistance has been declared as one of the ... becoming one of the most serious concerns. Hong Kong cannot be spared from the ... (CA-MRSA), or a seven-fold of the figure in 2007 – the year the disease ...
(Date:9/24/2019)... ... September 24, 2019 , ... The Grain Foods ... its Scientific Advisory Board. Dr. Holscher is an Assistant Professor of Nutrition in ... Sciences at the University of Illinois Urbana-Champaign, where she has affiliate appointments with ...
(Date:9/17/2019)... N.J. (PRWEB) , ... September 17, 2019 , ... ... announced that Julie Delaney, Director, Project and Clinical Supplies Management, Asia Pacific (APAC) ... the One Farrer Hotel, Singapore, on Sept. 25-26, 2019. , On Thursday, Sept. ...
(Date:9/17/2019)... ... ... Jennifer Hermansky and Fang Xie, Ph.D. , attorneys from ... Rising Stars. Hermansky and Xie, named an Immigration Rising Star and a Life Sciences ... areas. The list highlights attorneys “whose legal accomplishments transcend their age,” according to Law360. ...
Breaking Biology Technology: