Navigation Links
New technique eliminates toxic drugs in islet transplant in diabetic mice
Date:11/20/2008

unrong Luo, assistant professor of medicine in nephrology at the Feinberg School, was co-principal investigator for the study.

In the study, researchers took a type of white blood cell from the islet donor's spleen, called splenocytes, and treated them with a chemical that masked the cells' identity. They then injected these chemically treated cells into diabetic mice before and after the mice underwent islet cell transplantation. As a result, the immune system of the mice didn't try to reject the cells, because it didn't perceive them as foreign and dangerous.

When the same test was done without pre-treated cells, the immune system rejected the transplanted islets within 15 days.

In an upcoming study, Miller and Luo will work with mice that have autoimmune disease that destroys their islet cells, as occurs in type 1 diabetes. Researchers will use therapies that prevent the autoimmune system's response against its own beta cells (which are part of the islets) as well as prevent the recipient's immune responses against the transplanted islet cells.

"We have ways we can do both," Miller said. "Hopefully this next study will show we can take combined therapies for underlying autoimmune disease and transplanted islets. If we do that together, we hopefully can cure an animal who became diabetic from autoimmune disease." If successful, the next step would be testing the technique on human subjects.

Miller said this technique also has applications for treating other autoimmune diseases such as multiple sclerosis.


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
7. New X-ray technique targets terrorists and tumors
8. Technique controls nanoparticle size, makes large numbers
9. New technique could dramatically lower costs of DNA sequencing
10. New techniques create butanol
11. New radar satellite technique sheds light on ocean current dynamics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/27/2014)... NEW YORK , Aug. 27, 2014 /PRNewswire/ ... report is available in its catalogue: ... http://www.reportlinker.com/p02316674/Law-Enforcement-Biometrics-Market-in-North-America-2014-2018.html ... to assess individuals on the basis of their ... and identification of both physiological traits such as ...
(Date:8/27/2014)... PITTSBURGHLearning a new skill is easier when it is ... a trained pianist might learn a new melody more ... , Neural engineers from the Center for the Neural ... of Pittsburgh and Carnegie Mellon Universityhave discovered a fundamental ... happens. Published as the cover story in the Aug. ...
(Date:8/27/2014)... the greatest risk to Europe based upon a proxy ... researchers using a ,big data, approach to scientific research. ... and Global Health ranked the top 100 pathogens affecting ... a system which, they believe, will help governments across ... of infectious diseases, including as a result of climate ...
Breaking Biology News(10 mins):Law Enforcement Biometrics Market in North America 2014-2018 2Law Enforcement Biometrics Market in North America 2014-2018 3Law Enforcement Biometrics Market in North America 2014-2018 4Law Enforcement Biometrics Market in North America 2014-2018 5Pitt and Carnegie Mellon engineers discover why learning can be difficult 2Pitt and Carnegie Mellon engineers discover why learning can be difficult 3Big data approach identifies Europe's most dangerous human and domestic animal pathogens 2
... as 50 percent of all human protein-coding genes are ... onset and progression of cancer, others can actually suppress ... cancer therapy. They can also serve as potential biomarkers ... Cancer Biomarkers , investigators report on non-coding miRNAs ...
... have created stunning images of the branching patterns of individual ... eLife on Dec. 18, details the arrangement of ... branching patterns define ten distinct groups that, the researchers say, ... could hold clues for pain management and other areas of ...
... inexpensive new source of a widely used chemical for plastics, ... Succinic acid, traditionally drawn from petroleum, is one focus of ... 2004, the Department of Energy named succinic acid one of ... biological means and turned into high-value materials. Several ...
Cached Biology News:MicroRNAs present exciting opportunities for cancer therapy and diagnosis 2MicroRNAs present exciting opportunities for cancer therapy and diagnosis 3Why our backs can't read braille 2Why our backs can't read braille 3Soybeans a source of valuable chemical 2
(Date:8/27/2014)... DUBLIN , Aug. 27, 2014 ... "Global Stable Isotope Ratio Mass Spectrometer Industry Report ... The Global Stable Isotope Ratio Mass Spectrometer Industry Report ... current state of the global isotope ratio mass spectrometer ... of the industry including definitions, classifications, applications and industry ...
(Date:8/27/2014)... Boca Raton, FL (PRWEB) August 27, 2014 ... that are applied through the use of a handheld ... consumers across the United States. , The brand ... care unit. BIOEQUA researchers were surprised to learn that ... to be made extremely small and delivered directly to ...
(Date:8/27/2014)... 2014 WriteResult, LLC – a premier ... again shown superiority when it comes to meeting the ... ePRO portion of their most recent study closeout on-time ... chose WriteResult’s digital writing platform to collect Patient Reported ... to complete drew data from a number of assessments ...
(Date:8/26/2014)... San Diego, CA, and Bellingham, WA (PRWEB) August ... nanoscience and optical engineering, visions for next-generation wearable ... Light 2015 among numerous highlights at this year’s ... in the San Diego, California, Convention Center. More ... suppliers last week attended conferences, courses, an exhibition, ...
Breaking Biology Technology:Global Stable Isotope Ratio Mass Spectrometer Industry Report 2014 2BIOEQUA'S EQUA ESSENTIAL Product Line Redefines Skin Care & Now Available in America 2A Perfect Record: WriteResult Maintains a 100% On-Time ePRO Record with Latest Irritable Bowel (IBS) Study Data Lock 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 2Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 3Brighter, Busier SPIE Optics + Photonics Draws International Crowd to San Diego 4
... attract the presence of major pharmaceutical companies from out ... own environment, said a panel assembled Monday night by ... building the future today in Wisconsin has to do ... CEO Irene Hrusovsky. , ,Woody Hydrick, a senior consultant ...
... the next ten years, according to a proposal that has ... Senate for a vote this month. State Senator Joe Leibham, ... that would be regulated similarly to airports. , ,Leibhams bill, ... private space travel in the area, receive any potential federal ...
... the lineup for DEMO 2006 nears, Ive had plenty of ... launch. , ,Does a product in "beta" variously defined ... qualify as launch-ready? Must I have customers in the queue ... a shipping product that we've only talked about with our ...
Cached Biology Technology:Panel stresses drawing outside biotech firms to state 2Space port could open in Sheboygan in next 10 years 2Space port could open in Sheboygan in next 10 years 3When do you go from "beta" to "product launch"? 2When do you go from "beta" to "product launch"? 3
... in heart tissues, and is produced ... conditions. Treatment of cells with ... TIMP-4 in some cell types, but ... require concentration of cell culture media ...
Goat polyclonal to HSPC150 ( Abpromise for all tested applications). entrezGeneID: 29089...
Anti-MMP-13 Collagenase-3, amino terminal end of active enzyme; rabbit host...
...
Biology Products: