Navigation Links
New technique eliminates toxic drugs in islet transplant in diabetic mice
Date:11/20/2008

unrong Luo, assistant professor of medicine in nephrology at the Feinberg School, was co-principal investigator for the study.

In the study, researchers took a type of white blood cell from the islet donor's spleen, called splenocytes, and treated them with a chemical that masked the cells' identity. They then injected these chemically treated cells into diabetic mice before and after the mice underwent islet cell transplantation. As a result, the immune system of the mice didn't try to reject the cells, because it didn't perceive them as foreign and dangerous.

When the same test was done without pre-treated cells, the immune system rejected the transplanted islets within 15 days.

In an upcoming study, Miller and Luo will work with mice that have autoimmune disease that destroys their islet cells, as occurs in type 1 diabetes. Researchers will use therapies that prevent the autoimmune system's response against its own beta cells (which are part of the islets) as well as prevent the recipient's immune responses against the transplanted islet cells.

"We have ways we can do both," Miller said. "Hopefully this next study will show we can take combined therapies for underlying autoimmune disease and transplanted islets. If we do that together, we hopefully can cure an animal who became diabetic from autoimmune disease." If successful, the next step would be testing the technique on human subjects.

Miller said this technique also has applications for treating other autoimmune diseases such as multiple sclerosis.


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
7. New X-ray technique targets terrorists and tumors
8. Technique controls nanoparticle size, makes large numbers
9. New technique could dramatically lower costs of DNA sequencing
10. New techniques create butanol
11. New radar satellite technique sheds light on ocean current dynamics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... animal species for food or commercial food sale, has ... the decline of many species of primates and other ... than half of the species being consumed are birds, ... not only the meat made available for sale but ... by hunters and brought to villages for consumption, we ...
(Date:7/24/2014)... current biodiversity, the product of 3.5 billion years of ... history of life. But it may be reaching a ... literature and analysis of data published in Science ... loss and decline of animals is contributing to what ... sixth mass biological extinction event. , Since 1500, more ...
(Date:7/24/2014)... a low vision specialist at The University of Texas ... been awarded a grant to help Harris County residents ... or surgery. , Even with corrective lenses, many people ... there are a variety of low vision devices, such ... their vision loss. , Iyer is using the three-year, ...
Breaking Biology News(10 mins):Stanford biologist warns of early stages of Earth's 6th mass extinction event 2Stanford biologist warns of early stages of Earth's 6th mass extinction event 3UTHealth Dr. Bhavani Iyer awarded low vision grant 2
... Eight supply chain professionals were elected in June by the membership of ... existing members of SCC,s board. Newly elected board members, whose terms ... , , , , ... , Jane Barrett, Research Director, AMR ...
... , , LONDON, July 10 IBM (NYSE: ... executive agency of the UK Home Office, have signed a seven-year agreement ... upgrade to biometric passports and enhance the security of the UK border. ... (UKBA) Immigration and Asylum Fingerprint System (IAFS) which holds biometrics collected from ...
... On the heels of his discovery in Montana of ... paleontologist Anthony Martin has found evidence of more dinosaur burrows ... in Victoria, Australia. The find, to be published this month ... shared by dinosaurs of different species, in different hemispheres, and ...
Cached Biology News:UK Identity and Passport Service and IBM Sign 7-year National Biometric Identity Service (NBIS) Contract 2Down Under dinosaur burrow discovery provides climate change clues 2Down Under dinosaur burrow discovery provides climate change clues 3
(Date:7/24/2014)... have yet to materialise. Yet, scientists are making ... computers faster. One such approach relies on quantum ... applying an electric field. A new study demonstrates ... quantum dots (TQDs) with electrical impulses can help ... should TQDs be used as quantum information units, ...
(Date:7/24/2014)... -- Research and Markets has announced the ... report to their offering.  ... in vitro growth of plant or animal cells for ... production. Cell culture is a crucial step in tissue ... culture consumables are necessary for the in vitro production ...
(Date:7/24/2014)... 24, 2014 SRI International has been awarded ... Institute of Allergy and Infectious Diseases (NIAID), part of ... of potential therapies for HIV infection and AIDS. The ... and AIDS and the complications and opportunistic infections associated ... sexual transmission of HIV. According to ...
(Date:7/24/2014)... 24, 2014 2014 Deep Research ... is a professional and in-depth research report on ... Sulphate basic information, including its definition, classification, ... This research covers the international market analysis, including ... analysis covering macroeconomic environment & economic situation analysis, ...
Breaking Biology Technology:Global Cell Culture Market 2014-2018: Key Vendors are Becton, Dickinson and Co, EMD, GE Healthcare, Lonza Group, Sigma Aldrich and Thermo Fisher Scientific 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 2National Institute of Allergy and Infectious Diseases Awards SRI International Contract to Study New Therapies for HIV and AIDS 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 2Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 3Potassium Sulphate Market & SHMP Industry 2014 (Global, China) Analysis Now Available at DeepResearchReports.com 4
... TORONTO, Jan. 29 /PRNewswire-FirstCall/ - ARIUS Research Inc., ... next wave of,antibody therapeutics, today announced its financial ... year, ended November 30, 2007., "Fiscal 2007 ... by the,significant advancement we made with the pre-IND ...
... England, January 29 Circassia Ltd, a ... responses,announced today that it has successfully raised ... round funding. The investment,syndicate includes new investors ... existing investors, including Imperial Innovations and Lansdowne,Partners., ...
... nanotubes have a sound future in the electronics ... all-nanotube transistor radios to prove it., The nanotube ... the active functionality in the devices, represent important ... materials into high-speed analog electronics and other related ...
Cached Biology Technology:ARIUS announces fourth quarter and year-end fiscal 2007 financial results 2ARIUS announces fourth quarter and year-end fiscal 2007 financial results 3ARIUS announces fourth quarter and year-end fiscal 2007 financial results 4ARIUS announces fourth quarter and year-end fiscal 2007 financial results 5ARIUS announces fourth quarter and year-end fiscal 2007 financial results 6ARIUS announces fourth quarter and year-end fiscal 2007 financial results 7ARIUS announces fourth quarter and year-end fiscal 2007 financial results 8ARIUS announces fourth quarter and year-end fiscal 2007 financial results 9ARIUS announces fourth quarter and year-end fiscal 2007 financial results 10ARIUS announces fourth quarter and year-end fiscal 2007 financial results 11ARIUS announces fourth quarter and year-end fiscal 2007 financial results 12ARIUS announces fourth quarter and year-end fiscal 2007 financial results 13Circassia Raises GBP11 Million ($21.8 Million) in Oversubscribed Second Round Funding 2New kind of transistor radios shows capability of nanotube technology 2
... This product has been developed to ... peroxidase labeled proteins. Stability is increased ... to 2-8 centigrade. This product is ... no mercury or azide. This formulation ...
384 Well PCR Plate Carrier for Thermo-Sealer...
... a powerful tool for sample purification in ... DNA/RNA or protein purification as well as ... automated on the Genesis Series of instruments ... combination with the RoMa arm and Tecans ...
... Fluorescent Image Analyzer features fluorescent and radioisotope ... system. This powerful new research tool captures ... or radioisotopes at resolutions meeting the needs ... quality and flexibility make the FLA-8000 a ...
Biology Products: