Navigation Links
New technique eliminates toxic drugs in islet transplant in diabetic mice
Date:11/20/2008

unrong Luo, assistant professor of medicine in nephrology at the Feinberg School, was co-principal investigator for the study.

In the study, researchers took a type of white blood cell from the islet donor's spleen, called splenocytes, and treated them with a chemical that masked the cells' identity. They then injected these chemically treated cells into diabetic mice before and after the mice underwent islet cell transplantation. As a result, the immune system of the mice didn't try to reject the cells, because it didn't perceive them as foreign and dangerous.

When the same test was done without pre-treated cells, the immune system rejected the transplanted islets within 15 days.

In an upcoming study, Miller and Luo will work with mice that have autoimmune disease that destroys their islet cells, as occurs in type 1 diabetes. Researchers will use therapies that prevent the autoimmune system's response against its own beta cells (which are part of the islets) as well as prevent the recipient's immune responses against the transplanted islet cells.

"We have ways we can do both," Miller said. "Hopefully this next study will show we can take combined therapies for underlying autoimmune disease and transplanted islets. If we do that together, we hopefully can cure an animal who became diabetic from autoimmune disease." If successful, the next step would be testing the technique on human subjects.

Miller said this technique also has applications for treating other autoimmune diseases such as multiple sclerosis.


'/>"/>

Contact: Marla Paul
Marla-Paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
7. New X-ray technique targets terrorists and tumors
8. Technique controls nanoparticle size, makes large numbers
9. New technique could dramatically lower costs of DNA sequencing
10. New techniques create butanol
11. New radar satellite technique sheds light on ocean current dynamics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... Scientists have scoured cow rumens and termite guts for ... for the production of next-generation biofuels, but some of ... human lower intestine, researchers report. , Their study ... Academy of Sciences , is the first to use ... the human gut can digest fiber, breaking it down ...
(Date:9/23/2014)... could be as good for your mental as your ... by the University of Warwick,s Medical School using data ... BMJ Open focused on mental wellbeing and ... associated with an individual,s fruit and vegetable consumption. , ... or more portions of fruit and vegetables a day, ...
(Date:9/23/2014)... organisms, including humans, have parasitic DNA fragments called "jumping ... instructions in the process. And that phenomenon can result ... the University of Rochester now report that the "jumping ... when a multi-function protein stops keeping them in check ... In a study published today in Nature Communications ...
Breaking Biology News(10 mins):Search for better biofuels microbes leads to the human gut 2Search for better biofuels microbes leads to the human gut 3Eating five a day may keep the blues away 2A multi-function protein is key to stopping genomic parasites from 'jumping' 2
... replacement surgeries can help relieve joint pain common ... the debris from prosthetic joints leads to aseptic ... a Wayne State University researcher determined that the ... disintegration. There was one caveat, however: there are ...
... female mosquito cannot tell if the male that she has ... her eggs, according to a new study from scientists at ... journal Proceedings of the National Academy of Sciences , ... of malaria by interfering with the mosquitoes, ability to reproduce. ...
... ALAMOS, New Mexico, August 8, 2011A Los Alamos National ... the first time the critical role that an elusive ... aid in treatment of peptic ulcers or acid reflux ... waste into transportation fuels. In a paper appearing ...
Cached Biology News:Wayne State researcher discovers antibiotic useful for localized treatment of bone wear 2Mosquitoes can't spot a spermless mate 2Mosquitoes can't spot a spermless mate 3Researchers use neutrons to spy on the elusive hydronium ion 2
(Date:9/23/2014)... , Sept. 23, 2014 ... of the biomaterial family and are increasingly becoming ... body fluids and tissues without having a negative ... used as tissue replacement and tissue repair materials ... materials such as ceramics, glass, glass-ceramics, and composites. ...
(Date:9/23/2014)... Kamal Rashid , PhD, director of ... Center (BETC) and research professor of biology and biotechnology ... an international two-day event focused on biomanufacturing set for ... the event will bring together leaders of companies from ... and produce human therapeutics. “The growth curve for biomanufacturing ...
(Date:9/23/2014)... 2014 This is a professional ... the Phenolic Resin industry in Global and China.The ... including definitions, applications and industry chain structure. Global ... provided with a focus on history, developments, trends ... between the international and Chinese situation is also ...
(Date:9/23/2014)... de Reuil, France (PRWEB) September 23, 2014 ... to protection of laboratory personnel since 1968 and Burdinola, ... the development of a new filtered fume hood. ... above their laboratory fume hood, Burdinola will now offer ... for filtering a wide range of chemicals, best-in-class detection ...
Breaking Biology Technology:Global Bioactive Material Market 2014-2018 2Worcester Polytechnic Institute's Biomanufacturing Expertise to be Featured in Berlin 2Worcester Polytechnic Institute's Biomanufacturing Expertise to be Featured in Berlin 3Phenolic Resin Industry (International, China) Development Policy and Plan Now Available at ReportsnReports.com 2Erlab Partners with Burdinola to Deliver an Innovative Filtered Fume Hood 2
... , RESTON, Va., July 9 Mirixa Corporation, the ... the hiring of three new members to its growing ... FASCP, Kim Swiger, RPh, and Paul Miller, MS, RPh. ... closely with Mirixa,s pharmacy partners, state and national pharmacy ...
... FRANCISCO, Calif., July 9 Poniard Pharmaceuticals, Inc. (Nasdaq: ... therapies, today announced the appointment of Gary A. Lyons, to ... number of directors on the Poniard board to ten. , ... to help guide us as we move toward our goal ...
... , SUNNYVALE, Calif., July 9 Cepheid (Nasdaq: CPHD ... second quarter ended June 30, 2009, on Thursday, July 30, 2009, ... will host a management presentation at 2 p.m. Pacific Time on ... the live webcast, please visit Cepheid,s website at www.cepheid.com/investors ...
Cached Biology Technology:Mirixa Corporation Announces Key New Hires 2Poniard Pharmaceuticals Appoints Gary A. Lyons to Board of Directors 2Poniard Pharmaceuticals Appoints Gary A. Lyons to Board of Directors 3Cepheid Schedules 2009 Second Quarter Financial Results Announcement and Webcast 2
HAMP Immunogen: HAMP (AAH20612, 25 a.a. ~ 85 a.a) full length recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
... peptide transporter 2 (APT2) ... transporter PSF2) (Peptide supply ... transporter involved in antigen ... Antigen: ...
Raised to arginine vasopressin coupled to bovine thyroglobulin with carbodiimide ....
Chicken polyclonal to HAGH ( Abpromise for all tested applications). Antigen: Synthetic peptide, corresponding to N terminal amino acids 110-260 of Human HAGH. Entrez GeneID: 3029 Swiss ...
Biology Products: