Navigation Links
New technique could dramatically lower costs of DNA sequencing
Date:12/12/2007

CHAMPAIGN, Ill. Using computer simulations, researchers at the University of Illinois have demonstrated a strategy for sequencing DNA by driving the molecule back and forth through a nanopore capacitor in a semiconductor chip. The technique could lead to a device that would read human genomes quickly and affordably.

Being able to sequence a human genome for $1,000 or less (which is the price most insurance companies are willing to pay) could open a new era in personal medicine, making it possible to precisely diagnose the cause of many diseases and tailor drugs and treatment procedures to the genetic make-up of an individual.

Despite the tremendous interest in using nanopores for sequencing DNA, it was unclear how, exactly, nanopores could be used to read the DNA sequence, said U. of I. physics professor Aleksei Aksimentiev. We now describe one such method.

Aksimentiev and collaborators describe the method in a paper accepted for publication in the journal Nano Letters, and posted on the journals Web site.

Through molecular dynamics simulations, we demonstrate that back-and-forth motion of a DNA molecule in a nanopore capacitor 1 nanometer in diameter produces an electrostatic fingerprint that can be used to read the genetic sequence, said Aksimentiev, who also is a researcher at the Beckman Institute.

In the researchers simulations, performed at the universitys National Center for Supercomputing Applications, the nanopore capacitor consists of two conducting layers of doped silicon, separated by an insulating layer of silicon dioxide.

As DNA passes through the nanopore, the molecules electric field induces sequence-specific electrostatic potentials that can be detected at the top and bottom layers of the capacitor membrane.

A semiconductor device capable of reading the electrostatic potentials and decoding the genetic sequence is within the grasp of current technology, Aksimentiev said.

Nanometer pores in electronic membranes
'/>"/>

Contact: James E. Kloeppel
kloeppel@uiuc.edu
217-244-1073
University of Illinois at Urbana-Champaign
Source:Eurekalert

Page: 1 2

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Software Techniques Inc. Selects M2SYS Fingerprint Software to Meet Continuous Growth and Demand for Desktop Biometric Time & Attendance Solutions
7. New X-ray technique targets terrorists and tumors
8. Technique controls nanoparticle size, makes large numbers
9. Newly created cancer stem cells could aid breast cancer research
10. Obesity and lack of exercise could enhance the risk of pancreatic cancer
11. Finding that 1-in-a-billion that could lead to disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/17/2015)... and HILDEN, Germany , June 17, 2015 ... Frankfurt Prime Standard: QIA) today launched new Investigator ® ... laboratories in the United States . The ... analyze multiple key genomic markers (short tandem repeats or STRs) ... Sensor to evaluate the quality of DNA in each sample, ...
(Date:6/16/2015)... 16, 2015 Fingerprint Cards has received ... in the company,s portfolio from one of its module partners ... mainly take place during the third quarter 2015. The sensors ... . Jörgen Lantto, CEO of FPC, comments: ...   growing interest from smartphone OEMs in integrating touch fingerprint ...
(Date:6/12/2015)...  Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring, announced the United States ... analyze and identify participants of a video visitation ... This system can: , Identify that ... sign-on process is actually the person participating in ...
Breaking Biology News(10 mins):QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 2QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 3QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 4QIAGEN Launches New Genetic Fingerprinting Kits for U.S. Forensic Labs 5FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2Securus Announces Patent Issued for Authorized Presence Verification During Video Visitation 2
... Biologists from the University of Bonn have discovered that the ... near infrared range; this was thought to be unlikely until ... to hunt in shallow African rivers. The results will be ... available online now. A research team in the ...
... Kingdom, Oct. 29, 2012 /PRNewswire-iReach/ -- Materials characterization ... an exclusive distribution agreement with Affinity Biosensors LLC ... range of solutions that Malvern offers to the ... outside the USA and Canada. ...
... Cell Biology shows how a transcription factor called ... prevent neurodegeneration. The findings could pave the way for future ... diseases. In Lou Gehrig,s Disease (ALS) and other ... deteriorating first and the cells themselves perishing later. Axon degeneration ...
Cached Biology News:Infrared vision in a cichlid fish 2Exclusive agreement to distribute Affinity Biosensors' Archimedes system extends Malvern Instruments' biopharma solutions 2Exclusive agreement to distribute Affinity Biosensors' Archimedes system extends Malvern Instruments' biopharma solutions 3Exclusive agreement to distribute Affinity Biosensors' Archimedes system extends Malvern Instruments' biopharma solutions 4Stay-at-home transcription factor prevents neurodegeneration 2
(Date:7/6/2015)... leading Regulatory Service provider, today announced that it has opened a new ... . Navitas, expansion into Latin America will ... , the third largest economy in Latin America . ... ... regulatory professionals in close to or the same time zone and ...
(Date:7/5/2015)... ... July 06, 2015 , ... For many years, metal-on-quartz filters were the ... machine such as a Varian Cary 4000-7000, a Perkin Elmer 800-1100 or a Shimadzu ... even NIST used them for their SRM-2031 series going back for many years. Unfortunately, ...
(Date:7/3/2015)... 3, 2015 ... osoitteessa  http://www.openinnovationinscience.at Wienissä pidettävään ... Science" -jatkokoulutusohjelmaan 22.7.2015 asti.  ... tekemän, kansainvälisiä tutkijoita ja tiedemiehiä ... suurinta haastetta ovat kannustimien puute ...
(Date:7/3/2015)... ... 03, 2015 , ... The global failure analysis market is expected to reach ... bioscience market is expected to grow at the highest CAGR of 8.46%; its growth ... the research labs and academic institutions for root cause analysis of failure. The market ...
Breaking Biology Technology:Navitas Launches Latin American Regulatory Operations Hub in Bogota, Colombia 2Navitas Launches Latin American Regulatory Operations Hub in Bogota, Colombia 3FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 2FireflySci Simplifies the Calibration of UV Spectrophotometers with FUV Photometric Accuracy Standards 3Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 2Maailman ensimmäinen tiedemiesten koulutukseen suunniteltu avoimen innovaation ohjelma käynnistyy 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 2Failure Analysis Market to Grow at 7.52% CAGR to 2020 3Failure Analysis Market to Grow at 7.52% CAGR to 2020 4Failure Analysis Market to Grow at 7.52% CAGR to 2020 5
... 27 Article One Partners, the world,s largest patent ... million round of institutional funding with Alleghany Capital Corporation, ... and other investors. The funding will be used to further ... validation sector by enhancing existing products and services, developing new ...
... based on sniffing inhaling and exhaling through the ... wheelchairs or communicate with their loved ones. Sniffing technology ... a sort of ,third hand, to assist healthy surgeons ... engineers Dr. Anton Plotkin and Aharon Weissbrod and research ...
... July 26 Advanced Life Sciences ... biopharmaceutical company engaged in the discovery, development and commercialization ... oncology and respiratory diseases, today announced that the Company ... with The University of British Columbia (UBC) ...
Cached Biology Technology:Article One Announces Completion of Funding from Alleghany Corporation 2Article One Announces Completion of Funding from Alleghany Corporation 3New invention at the Weizmann Institute 2New invention at the Weizmann Institute 3Advanced Life Sciences Expands Antibiotic Pipeline 2Advanced Life Sciences Expands Antibiotic Pipeline 3Advanced Life Sciences Expands Antibiotic Pipeline 4
... Vaginal Keratinocyte Progenitors, Rabbit, and media. Cryo-preserved ... 10% DMSO at passage 25 (approx), supplied ... cell culture is supplied as a long-term ... additional 6 months of continuous growth from ...
... The MagneGST™ Protein Purification System ... method for the purification of glutathione-S-transferase ... particles (MagneGST™ Particles) are used to ... crude or cleared lysate using either ...
... Useful for the mechanical harvesting of cells ... ensures even contact with the growth surface ... 75cm flasks • Individually wrapped • Sterilized ... This CLS number is a new product ...
... Assay Kits are ideal for studying ... compounds using fluorescence polarization (FP) The ... glutathione transferase to the ligand binding ... and a proprietary, fluorescently-tagged progesterone ligand, ...
Biology Products: