Navigation Links
New technique captures chemical reactions in a single living cell at unprecedented resolution
Date:11/19/2007

Berkeley -- Bioengineers at the University of California, Berkeley, have discovered a technique that for the first time enables the detection of biomolecules' dynamic reactions in a single living cell.

By taking advantage of the signature frequency by which organic and inorganic molecules absorb light, the team of researchers, led by Luke Lee, professor of bioengineering and director of UC Berkeley's Biomolecular Nanotechnology Center, can determine in real time whether specific enzymes are activated or particular genes are expressed, all with unprecedented resolution within a single living cell.

The technique, described in the Nov. 18 issue of the journal Nature Methods, could lead to a new era in molecular imaging with implications for cell-based drug discovery and biomedical diagnostics.

The researchers point out that other techniques, such as nuclear magnetic resonance, can at best provide information about a cluster of cells. But to determine the earliest signs of disease progression or of stem cell proliferation, it's necessary to drill down deeper to the molecular dynamics within a single cell.

To study the biochemical processes of a cell, scientists currently cut through its outer membrane to separate and analyze the cellular components. That method can never provide a real-time view of how components function together because the cell is killed in the process of extracting its components.

"Until now, there has been no non-invasive method that exists that can capture the chemical fingerprints of molecules with nanoscale spatial resolution within a single living cell," said Lee, who is also the co-director of the Berkeley Sensor and Actuator Center. "There is great hope that stem cells can one day be used to treat diseases, but one of the biggest challenges in this field is understanding exactly how individual cells differentiate. What is happening inside a stem cell as it develops into a heart muscle inst
'/>"/>

Contact: Sarah Yang
scyang@berkeley.edu
510-643-7741
University of California - Berkeley  
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. New technique can be breakthrough for early cancer diagnosis
2. University of Leicester scientists discover technique to help friendly bacteria
3. New technique reveals subtle force-induced changes in biomolecules conformation
4. New magnetic separation technique might detect multiple pathogens at once
5. Amber specimen captures ancient chemical battle
6. New light trap captures larval stage of new species; DNA barcode technology used
7. Cold Spring Harbor Protocols highlights a method that captures cell growth and activity
8. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
9. American Chemical Societys Weekly PressPac -- Aug. 8, 2007
10. Thermochemical process converts poultry litter into bio-oil
11. New chemically-sensitive MRI scan may bypass some invasive diagnostic tests in next decade
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New technique captures chemical reactions in a single living cell at unprecedented resolution
(Date:8/25/2014)... Wash.Five years ago this month, one of the first ... Washington State University campus, striking some 2,000 people. A ... of data gathered at the time to gain insight ... the virus,s rapid spread across the university community., The ... cases came in to the university,s Health and Wellness ...
(Date:8/25/2014)... battery-powered DNA diagnostic device invented at New Zealand,s ... commonly used field tool for rapidly detecting suspected ... the level of infection. , The breakthrough device, ... Queenstown Molecular Biology main meeting. It takes advantage ... target DNA sequences in real-time, without the need ...
(Date:8/25/2014)... a device the size of a cell phone may ... according to a team of engineers., "For biological testing ... said Tony Jun Huang, professor of engineering science and ... of the cells, damages them in any way, the ... waves can separate cells using very small amounts of ...
Breaking Biology News(10 mins):WSU flu outbreak provides rare study material 2WSU flu outbreak provides rare study material 3Revolutionary handheld DNA diagnostic unit allows lab-quality analysis in the field 2Tilted acoustic tweezers separate cells gently 2
... for many people with depression and anxiety disorders, and ... care providers, according to researchers who analyzed the results ... shown to have tremendous benefits for mental health," says ... Program at Southern Methodist University in Dallas. "The more ...
... at Ume University and the Sahlgrenska Academy at the University ... can be found in fish that have been swimming in ... found in higher concentrations in the blood of fish than ... this hormone can lead to infertility in fish. The ...
... neurodegenerative disease spinocerebellar ataxia type 5 (SCA5) damages nerve ... report that the defective protein responsible for the disease ... inside neurons. The study appears in the April 5 ... ( www.jcb.org ). SCA5 results from a faulty ...
Cached Biology News:Mental health providers should prescribe exercise more often for depression, anxiety 2Medicine residues may threaten fish reproduction 2Defective protein is a double hit for ataxia 2
(Date:8/26/2014)... San Francisco, CA (PRWEB) August 26, 2014 ... to reach USD 8,020.1 million by 2020, according to ... demand for personalized medicine and theranostics, and the subsequent ... be key factors driving market growth over the next ... population and chronic diseases such as cancer, coupled with ...
(Date:8/26/2014)... Genedata, a leading provider of ... science research, today announced the Genedata Screener® ... in Asia, Europe, and North America during September ... leading research organizations will gather for annual User ... and upcoming challenges in all areas of screening. ...
(Date:8/26/2014)... 26, 2014   Loveland Products, a subsidiary of ... crop input products and proprietary products provider for ... has acquired a controlling interest in Agricen, a ... delivering biochemical-based products for efficient and sustainable plant ... growing plant nutrition brands, Accomplish ® LM ...
(Date:8/26/2014)... -- That,s Nice LLC, a research-focused strategic marketing agency dedicated ... a new dedicated team that will support clients with ... current and new staff in both market research and ... Guy Tiene has been hired as Director ... previously Director of Marketing for Royal DSM,s Pharmaceutical Products ...
Breaking Biology Technology:World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 2World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 3World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 4World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 5World Molecular Diagnostics Market Is Expected To Grow To $8,020.1 Million From 2014 To 2020: Grand View Research, Inc 6Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 2Thought Leaders to Explore Innovations in SPR & Combination Screening at Genedata Screener User Group Meetings 3Agrium, through Loveland Products, Acquires a Controlling Interest in Agricultural Biotechnology Company Agricen 2Agrium, through Loveland Products, Acquires a Controlling Interest in Agricultural Biotechnology Company Agricen 3Agrium, through Loveland Products, Acquires a Controlling Interest in Agricultural Biotechnology Company Agricen 4That's Nice Announces Expanded Offering For Strategic Content And Public Relations 2That's Nice Announces Expanded Offering For Strategic Content And Public Relations 3
... just the expected crowd of educators is congregating at ... Conference that runs through Friday; as the technologies ... fields involved. In addition to K-12 and higher education ... and military organizations. , ,Distance Learning 2005 is addressing ...
... The Centers for Medicare and Medicaid Services plan to officially ... Vista within the next few weeks, according to news accounts ... ,CMS officials hope that providing the new program, known as ... records by private clinicians. , ,Vista, a software program used ...
... Ann Stunden, director of the Division of Information Technology ... 2005 award for information technology leadership from the national ... for "strong and ground-breaking leadership in the information technology ... ago." , ,A co-founder and executive director of ...
Cached Biology Technology:Education conference focusing on importance of integrating technology 2Education conference focusing on importance of integrating technology 3Education conference focusing on importance of integrating technology 4
Identify and characterize Phosphoinositide (PI(4,5)P2) binding...
... Immunogen corresponds to amino acids 2-105 from ... been successfully used in Western blot, immunocytochemistry ... this antibody detects an ~ 60 kDa ... also been used in immunoprecipitation and immunocytochemical ...
Caspr2 Antigen: Fusion protein amino acids 96-1265 (extracellular domain) of human Caspr2 Accession Number: NP_054860...
... Our Accumix standard is a new tuning ... electrospray ionization mass spectrometry. Accumix is ... mass range coverage for both tuning and ... and LTQ-MS) and Fourier transform mass spectrometers. ...
Biology Products: