Navigation Links
New study reveals ways to better inhibit blood clots
Date:5/19/2010

Fibrin, the primary ingredient of blood clots, creates a fibrous network that stems the loss of blood at an injury site. But beyond this essential work, fibrin can also cause heart attack, stroke and tissue damage by forming clots that block blood vessels.

Fibrin forms when an enzyme removes parts of a blood protein called fibrinogen, exposing "knobs" that fit into "holes" located on both ends of fibrinogen molecules. Uncovering these knobs allows the fibrinogen molecules to attach to one another, forming a fibrin network. To inhibit unwanted fibrin formation, researchers have developed synthetic knobs to fill the holes, but the best amino acid sequence and structure for these knobs have not been well investigated.

A new study published online today in the journal Blood reveals factors that could improve the binding of synthetic fibrin knobs to holes and the structures of these knobs in solution. The study also identifies a novel synthetic knob that displays a 10-fold higher affinity for fibrinogen holes than current synthetic knobs. This research was supported by the National Institutes of Health and the Wallace H. Coulter Foundation.

"Understanding the fundamentals of this knob-hole interaction will lead to a more thorough knowledge of fibrin assembly mechanisms and allow us to establish criteria for designing superior anticoagulants with high hole affinity that can inhibit fibrin assembly," said Thomas Barker, an assistant professor in the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University.

Barker, postdoctoral fellow Sarah Stabenfeldt and School of Computational Engineering graduate student Jared Gossett investigated the interactions between holes and short synthetic peptides modeled after real fibrin knob sequences. They focused specifically on modeling the binding interaction and characterizing the structure of the peptides in solution.

Using a technique ca
'/>"/>

Contact: Abby Vogel
avogel@gatech.edu
404-385-3364
Georgia Institute of Technology Research News
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
New study reveals ways to better inhibit blood clots
(Date:10/31/2014)... the world,s largest producer of cocoa. Chocolate trees ( ... ha region of rainforest in the state of Bahia, ... the surrounding rainforest was a biodiversity hotspot, the chocolate ... seeds introduced in the mid 1700s, had very low ... Pereira, "This scenario created a very romantic, but extremely ...
(Date:10/31/2014)... the air out of a nagging mystery about the development ... as to why animal species didn,t flourish sooner, once sufficient ... the end of the Proterozoic period, about 800 million years ... when most researchers think there also was plenty of oxygen? ... after all. , In a study published Oct. 30 in ...
(Date:10/31/2014)... the war against Ebola one important hurdle has just ... at the University of North Carolina at Chapel Hill ... mice that can be infected with Ebola and display ... published in the current issue of Science , ... vaccines, which are desperately needed to curb the worldwide ...
Breaking Biology News(10 mins):Scientists seek cure for devastating witches' broom disease of the chocolate tree 2Scientists seek cure for devastating witches' broom disease of the chocolate tree 3Lack of oxygen delayed the rise of animals on Earth 2Improved mouse model will accelerate research on potential Ebola vaccines, treatments 2
... a nanomedicine milestone today as they announced the creation ... forms a partnership between university researchers and an international ... treatment created at MU. Shasun Pharmaceuticals Ltd., one ... new company in partnership with MU nanomedicine experts Kattesh ...
... international effort, on the scale of the Human Genome ... cancer cells. HGP was the international scientific research project ... Within a decade, they believe, results of the new ... customized to their own biology. The perspective appears in ...
... sharks may be too weak to capture and kill large marine ... Biomechanics by an international team of scientists. , The researchers also ... matter how widely their jaws are open, thanks to a unique ... most successful predators of all time. , The study is the ...
Cached Biology News:MU cancer scientists form new company with international pharmaceutical firm 2MU cancer scientists form new company with international pharmaceutical firm 3Teenage great white sharks are awkward biters 2
(Date:10/31/2014)... Having access to safe drinking water ... in many corners of the globe. It’s a major ... northwestern Bolivia where many have been sickened by unclean ... University’s School of Engineering has been working to improve ... “the united college for the peasants.” A branch university ...
(Date:10/31/2014)... Edwardsville, Ill. (PRWEB) October 31, 2014 ... Edwardsville’s Department of Historical Studies within the College of ... at SIUE to record the history of alcohol-based fuels ... politicians, and many others have been working to build ... an important but overlooked aspect of the state's agricultural ...
(Date:10/31/2014)... 31, 2014 Brady (NYSE:BRC), ... today announced a new video testimonial on ... the video, a research technician at the BloodCenter of ... to labeling and storing hundreds of thousands of samples, ... her research. , “At Brady, we design our label ...
(Date:10/31/2014)... -- Atlanta-based Intellimedix could make a positive contribution to ... by suggesting a new, computational approach for investigating ... Computational Systems Biology have spent years developing computer ... existing drugs through systematic repurposing, and their technology ... Ebola. Logo - http://photos.prnewswire.com/prnh/20141030/155702LOGO ...
Breaking Biology Technology:Fairfield University School of Engineering project reduces illness in rural community 2Fairfield University School of Engineering project reduces illness in rural community 3SIUE History Prof Manuel Working on Biofuels Book with NCERC 2SIUE History Prof Manuel Working on Biofuels Book with NCERC 3Brady Debuts New Lab Label Testimonial Video 2Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2
... ... of the National Institutes of Health (NIH), awarded a $2.18 million grant to Aciont Inc. ... , ... City, UT (PRWEB) December 10, 2009 -- The National Eye Institute (NEI), a division of ...
... , , ... TAI,AN, China, Dec. 10 /PRNewswire-Asia-FirstCall/ -- China Biologic,Products, Inc. (Nasdaq: ... biopharmaceutical companies in China, today announced,that the Company,s senior management team ... City at 9:30 a.m. ET on Tuesday, December 15,2009. , ...
... SEATTLE, Dec. 10 Dendreon Corporation (Nasdaq: DNDN ) ... chief operating officer, effective January 4, 2010. Mr. Bishop ... at Bayer, where he was responsible for a diverse portfolio ... served as an executive vice president of Bayer HealthCare LLC. ...
Cached Biology Technology:NEI Awards a Two-Year $2.18 Million SBIR Grant to Aciont 2NEI Awards a Two-Year $2.18 Million SBIR Grant to Aciont 3China Biologic Products to Ring NASDAQ Opening Bell 2China Biologic Products to Ring NASDAQ Opening Bell 3Dendreon Appoints Hans Bishop as Chief Operating Officer 2
... Fiberboard boxes are ideal for use in refrigerators, freezers, ... racks. Four vibrant colors allow for color coding to ... liquid nitrogen drainage or promote cool air circulation. Supplied ... holds 81 tubes. Box dimensions: 13 x ...
Sterile glass 5 mm beads that make spreading bacterial and yeast cultures easy. Can be washed, autoclaved and reused....
Similar to proteasome (prosome, macropain) 26S subunit, ATPase, 1 Antigen: Recombinant Protein...
RABBIT ANTI AMPHOTERIN...
Biology Products: