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New study pinpoints why some microbial genes are more promiscuous than others
Date:3/16/2011

th similar degrees of connectivity, the importance of gene function disappeared. "The reason some proteins are rarely acquired is because of how connected they are, not because of their function," said co-author Uri Gophna of Tel Aviv University.

Genes whose protein products rely on many partners to do their job are less likely to work properly in a new host, Gophna said. Transferring a highly connected gene into a new host is like importing a fax machine into a remote village, he explained. "While the machine itself is potentially useful, it needs a number of additional connections to work electricity, a phone line, a supply of paper, possibly a technician. If one of these is missing the machine becomes useless and ends up as junk."

Bacteria are more likely to adopt 'loner' genes than genes that are well-connected, the authors added. "If you think of the cell like a machine, it's much more difficult to exchange the hub of a machine than some of its accessories," Pupko said.


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Contact: Robin Ann Smith
rsmith@nescent.org
919-668-4544
National Evolutionary Synthesis Center (NESCent)
Source:Eurekalert

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