Navigation Links
New study finds way to stop excessive bone growth following trauma or surgery
Date:9/23/2009

(PHILADELPHIA) A recent United States Army study found that excessive bone growth, also known as heterotopic ossificiation (HO), affects up to 70 percent of soldiers who are severely wounded during combat. A much smaller percentage of the civilian population also suffers from HO following trauma or invasive surgery. The excessive bone forms within muscles and other tissues causing severe pain, reduced mobility and even local paralysis if untreated. A new study by Thomas Jefferson University researchers found a way to prevent HO in animal models by shutting the process off in its early stages. The study, reported in September's Journal of Orthopaedic Research, is expected to lead to clinical trials and may hopefully provide a new, effective and safe treatment for HO.

"This is a major breakthrough in HO research," said Primary Investigator Maurizio Pacifici, Ph.D, director of Orthopedic Research at Jefferson Medical College of Thomas Jefferson University. "We are able to largely prevent formation and progression of HO lesions. We presented our initial results at a recent U.S. Army Extremity War Injuries Symposium in Washington D.C. and they were very well-received and have elicited great hope on the part of military physicians to finally have a way to stop HO in troops wounded in war zones."

In the ongoing study sponsored by the U.S. Army, Jefferson scientists were able to prevent HO by disrupting a series of cellular changes that are needed to produce HO. Following a trauma or invasive surgery, the condition begins when progenitor and stem cells are recruited to the injured site and give rise to cartilage tissue that then turns to bone. This multi-step process is regulated by several factors. One of these factors is a protein in the nucleus of the progenitor cells that is called the retinoid alpha receptor. This receptor must be turned off before the progenit
'/>"/>

Contact: Rick Cushman
richard.cushman@jefferson.edu
215-955-2240
Thomas Jefferson University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Childhood obesity indicates greater risk of school absenteeism, Penn study reveals
2. A study by the MUHC and McGill University opens a new door to understanding cancer
3. Study begins to reveal clues to the cause and progression of sepsis
4. Clones on task serve greater good, evolutionary study shows
5. New study warns limited carbon market puts 20 percent of tropical forest at risk
6. New study examines how rearing environment can alter navigation
7. Study links cat disease to flame retardants in furniture and to pet food
8. New continent and species discovered in Atlantic study
9. Study shows link between alcohol consumption and hiv disease progression
10. Feeling hot, hot, hot: New study suggests ways to control fever-induced seizures
11. Study finds environmental tests help predict hospital-acquired Legionnaires disease risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... have previously shown that a genetic pre-disposition to be ... new study, Frank Booth, a professor in the MU ... between the genetic pre-disposition for high levels of exercise ... , For his study, Booth selectively bred rats that ... Booth then put the rats in cages with running ...
(Date:4/15/2014)... ITHACA, N.Y. If an insect drew a line ... would be a tangled mess. But there,s method to ... of mechanical engineering and physics, who tries to find ... Photo: https://cornell.box.com/tbeetle , It turns out the ... an optimal reorientation dance as it chases its prey ...
(Date:4/15/2014)... how social behavior has developed over the course of ... have gained new insights from the study of earwigs. ... the siblings share what is available amongst themselves, especially ... of the Evolutionary Biology section of the Institute of ... team of biologists from Mainz University and the University ...
Breaking Biology News(10 mins):Genetic pre-disposition toward exercise and mental development may be linked 2Photo: Tiger beetle's chase highlights mechanical law 2Sibling cooperation in earwig families gives clues to early evolution of social behavior 2
... BATON ROUGE, LAKeeping with the global "green" trend, ... lessons to enhance students, science knowledge. Studies have ... raises not just science scoresenvironmental-based lessons can also ... Naturally, educators are interested in developing new ways ...
... Scientists studying how bacteria under stress collectively weigh and ... insights into how humans make strategic decisions that affect ... society. Their study, published this week in the ... the National Academy of Sciences , was accomplished when ...
... available in French . , Montreal, December ... mechanism that prevents cancer. In the December 11 edition of ... Universit de Montral and the Universit de Sherbrooke explain how ... of cytokines, hormones that are culprits in cancer-prone chronic inflammation ...
Cached Biology News:Students learn environmental stewardship, improve science scores 2Bacteria provide new insights into human decision making 2Bacteria provide new insights into human decision making 3Bacteria provide new insights into human decision making 4Bacteria provide new insights into human decision making 5Scientists identify natural anti-cancer defenses 2
(Date:1/15/2014)... -- TaiGen Biotechnology Company, Limited ("TaiGen") today announced ... R-Pharm, a leading Russian pharmaceutical company, to develop ... Russian Federation , ... Commonwealth Independent States (CIS). Nemonoxacin is a novel antibiotic ... caused by drug-resistant bacteria. Under the terms of ...
(Date:1/14/2014)... January 14, 2014 Carahsoft and ... for Thursday, January 23, 2014 at 2pm EST ... into Actionable Knowledge.” The topic focuses on how ... knowledge to drive mission critical decisions for government ... hour. , Synopsis: Big Data has become an ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications ... business, and media events in the United States ... its former associate Virginia Cox , JD, is returning ... Virginia Cox re-joins 3D after more ... Office of External Affairs at the U.S. Food and Drug ...
(Date:1/14/2014)... New York, NY (PRWEB) January 14, 2014 ... has initiated coverage of Alliqua, Inc. (OTCQB: ALQA). ... manufacturing, and marketing proprietary products to serve the ... http://equitiesiq.com/reports/alliqua/ , In late 2012, Alliqua was ... which launched the company’s new strategy to become ...
Breaking Biology Technology:TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 2TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 3TaiGen Biotechnology Signed Exclusive License Agreement with R-Pharm for Nemonoxacin (Taigexyn(R)) 4Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2Former FDA Associate Commissioner Returns To 3D Communications 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... , , , , for one-step RT-PCR ... 016 338 50 reactions , Cat. No. 2 016 346 250 reactions ... Description , , , The system contains a unique ... , Note: C. therm. Polymerase provided ...
... , , , Mark R. Kagan 1 , Julian Phillips 2 , , ... 1Thermo Finnigan, Piscataway, NJ; , 2Thermo Finnigan, San Jose, CA; , ... Chemical Structure Validation , The data presented here can be acquired using ... , Introduction , ...
... , , , Jack Cunniff, Philip Tiller, Michael Harvey, , ... , , , , ... Finnigan LCQ , Series of ion trap mass spectrometers. , ... For more than five thousand years tea has been used in China as an ...
Cached Biology Technology:C. therm. Polymerase One-Step RT-PCR System 2C. therm. Polymerase One-Step RT-PCR System 3Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 2Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 3Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 4Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 5Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 6Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 7Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 8Analyzing Trace-Level Impurities of a Pharmaceutical Intermediate Using , an LCQ Deca Ion Trap Mass Spectrometer and the Mass Frontier , Software Package 9Structural Determination of Flavonoids Using MSn 2Structural Determination of Flavonoids Using MSn 3Structural Determination of Flavonoids Using MSn 4
... GeneBLAzer cell-based assays utilize the ... of the negatively charged fluorescent beta-lactamase ... esters readily enter the cell, where ... converts them into their negatively charged ...
... GeneBLAzer cell-based assays utilize the membrane-permeant ... the negatively charged fluorescent beta-lactamase substrates, ... readily enter the cell, where cleavage ... them into their negatively charged forms, ...
1M stock solution (238mg/ml)...
Request Info...
Biology Products: