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New studies may explain fractures in some who take osteoporosis drugs
Date:11/14/2013

d microscopic examinations and found differences in bone remodeling dynamics that were influenced by inherited differences among the animals.

"Baboons are anatomically and physiologically very similar to humans, and these animals live a long time, so they develop many of the same age-related diseases that we do," Havill said. "This makes them a good model for age-related diseases such as osteoporosis. The results of this study suggest an explanation for why some women respond differently to the widely prescribed bisphosphonates."

"This supports the potential for a scenario in which certain individuals who are genetically predisposed to cortical microstructure that is less mechanically advantageous may experience disadvantageous responses to remodeling suppression, such as being at higher risk for atypical femoral fractures," Havill wrote in the study.


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Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

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