Navigation Links
New studies may explain fractures in some who take osteoporosis drugs
Date:11/14/2013

Research with baboons at the Texas Biomedical Research Institute may help explain why some people who take bone-strengthening drugs like bisphosphonates are at-risk for atypical fractures in the long bones in their legs.

Texas Biomed scientist Lorena M. Havill, Ph.D. and colleagues at the Southwest Research Institute and Indiana University examined femurs of deceased baboons and found differences in the microstructure of their femurs that she traced to genetic variation among the animals. The study supports the theory that genetic variations may regulate bone remodeling, a natural process during which mature bone tissue is removed from the skeleton so that new tissue can be added. These genetic differences could explain why a small percentage of older women suffer a distinct type of fracture of their femurs when they take bisphosphonates, a type of medication prescribed for millions of people with the bone-weakening disease osteoporosis.

The study, funded by the Texas Biomedical Forum, the Texas Biomed Founder's Council, the San Antonio Area Foundation, and the National Institutes of Health (NIH), is published in the November issue of the journal Calcified Tissue International.

In osteoporosis, bone remodeling happens faster than the growth of new bone tissue to replace the lost bone. Bisphosphonates suppress remodeling, allowing the accumulation of bone tissue.

Havill and others have theorized that some women are genetically predisposed to slower remodeling in the absence of osteoporosis. This genetic difference could be causing the drugs to have a greater effect on them and weaken their bones in areas not typically prone to osteoporotic fractures.

In their study, Havill and her colleagues examined femurs from 101 baboons from the pedigreed colony at Southwest National Primate Research Center. All had died for reasons unrelated to this research project. Their bones were obtained during necropsy and preserved. The researchers did microscopic examinations and found differences in bone remodeling dynamics that were influenced by inherited differences among the animals.

"Baboons are anatomically and physiologically very similar to humans, and these animals live a long time, so they develop many of the same age-related diseases that we do," Havill said. "This makes them a good model for age-related diseases such as osteoporosis. The results of this study suggest an explanation for why some women respond differently to the widely prescribed bisphosphonates."

"This supports the potential for a scenario in which certain individuals who are genetically predisposed to cortical microstructure that is less mechanically advantageous may experience disadvantageous responses to remodeling suppression, such as being at higher risk for atypical femoral fractures," Havill wrote in the study.


'/>"/>

Contact: Joseph Carey
jcarey@txbiomed.org
210-258-9437
Texas Biomedical Research Institute
Source:Eurekalert

Related biology news :

1. Immunity studies cross scientific and continental borders (video)
2. ARC Future Fellows awarded $2.2M for immune and inflammation studies
3. Generation length for mammals: An essential reference point for conservation studies
4. Population Council to present more than 40 studies at International Conference on Family Planning
5. Mouse studies reveal promising vitamin D-based treatment for MS
6. Sam Houston State studies DNA preservation in mass disasters
7. HB-EGF protects intestines from a variety of injuries, pair of studies suggests
8. Neutron studies of HIV inhibitors reveal new areas for improvement
9. Mercy Lab Offers Faster On-demand Diabetes Testing, Cellular Studies
10. Family studies suggest rare genetic mutations team up to cause schizophrenia
11. UCI researchers find sea anemone venom-derived compound effective in anti-obesity studies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/14/2016)... , March 14, 2016 NXTD ) ... mobile commerce market, announces the airing of a new series ... the week of March 21 st .  The commercials will ... its popular Squawk on the Street show. --> ... the growing mobile commerce market, announces the airing of a ...
(Date:3/10/2016)... PUNE, India , March 10, 2016 ... to a new market research report "Identity and Access ... SSO, & Audit, Compliance, and Governance), by Organization Size, ... Forecast to 2020", published by MarketsandMarkets, The market is ... to USD 12.78 Billion by 2020, at a Compound ...
(Date:3/9/2016)... , March 9, 2016  Crossmatch ® ... and enrollment solutions, today announced the addition of ... Altus multi-factor authentication platform. New contextual ... managers to step-up security where it,s needed most ... Washington, DC . --> ...
Breaking Biology News(10 mins):
(Date:4/29/2016)... 2016 According to a ... "Separation Systems for Commercial Biotechnology Market - Global ... 2015 - 2023", the separation systems for commercial ... in 2014 and is projected to expand at ... to reach US$ 19,227.8 Mn in 2023. ...
(Date:4/28/2016)... April 28, 2016 The report ... Brayton Cryocoolers), Service (Technical Support, Product Repairs & Refurbishment, ... Global Forecast to 2022", published by MarketsandMarkets, the global ... by 2022, at a CAGR of 7.29% between 2016 ... Tables and 94 Figures spread through 159 Pages and ...
(Date:4/28/2016)... ... April 28, 2016 , ... Morris ... open house for regional manufacturers at its Maple Grove, Minnesota technical center, May ... Group, Chiron and Trumpf. Almost 20 leading suppliers of tooling, accessories, software ...
(Date:4/27/2016)... April 27, 2016 NanoStruck ... (OTCPink: NSKQB) ( Frankfurt : 8NSK) ... Pressemitteilung vom 13. August 2015 die Genehmigung von ... um zusätzliche 200.000.000 Einheiten auf 400.000.000 Einheiten zu ... bringen. Davon wurden 157.900.000 Einheiten mit dem ersten ...
Breaking Biology Technology: