Navigation Links
New sickle cell anemia therapy advances to Phase II clinical trials
Date:6/12/2013

reatening problems."

The sickle cell trial grew out of research by Dr. Linden, who is a leading expert on adenosine receptors, which are known to act as a natural brake on inflammation. While Dr. Linden had previously explored adenosine's role in protecting tissues from damage due to low blood flow in single tissues such as in heart disease, he was struck one day with the idea that it might also protect people with sickle cell disease, who suffer tissue damage from poor blood flow to most tissues.

Dr. Linden began testing his theory in mouse models about four years ago and found that adenosine-like compounds significantly reduced the damaging effects of the disease. He was aware of an existing FDA approved adenosine-like drug, Lexiscan that had already been approved for another use. "This was good news since it meant that Lexiscan was known to be safe in humans and could probably gain rapid approval if proven effective in clinical trials as a treatment for sickle cell disease," he said.

Dr. Linden joined forces with Dr. Nathan, who participated in the development of the only existing FDA-approved drug for sickle cell treatment, hydroxyurea, and another clinical collaborator, Dr. Field, to seek NIH funding for the Lexiscan trial. They launched the trial's first phase in 2010 using patient volunteers from Brigham and Women's Hospital in Boston and Washington University in St. Louis.

In the trial, Dr. Nathan, Dr. Field and other clinicians collected blood from patients and sent it to Dr. Linden in La Jolla for analysis of white blood cell inflammation. Gene Lin, Ph.D., a scientist in Linden's lab, has been a significant contributor to the analysis effort. The same protocol will be used in the trial's second phase.

Lexiscan is approved as a pharmacologic stress agent used for myocardial perfusion imaging (MPI), a procedure that measures coronary blood flow to help in the diagnosis of heart disease. Lexiscan is u
'/>"/>

Contact: Bonnie Ward
contact@liai.org
619-303-3160
La Jolla Institute for Allergy and Immunology
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Sickle cell trait can cause sudden cardiac death in black athletes: Why is this controversial?
2. Potential gene therapy approach to sickle cell disease highlighted at ASH
3. Nature study reveals loss of essential blood cell gene leads to anemia
4. Why a hereditary anemia is caused by genetic mutation in mechanically sensitive ion channel
5. Cleveland Clinic research shows anemia drug does not improve health of anemic heart failure patients
6. Discovery may help prevent chemotherapy-induced anemia
7. Scientists identify potential drug target for treatment-resistant anemias
8. Stanford scientists develop gene therapy approach to grow blood vessels in ischemic limbs
9. Ottawa researchers to lead world-first clinical trial of stem cell therapy for septic shock
10. New insight into mechanisms behind autoimmune diseases suggests a potential therapy
11. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/29/2014)... kind of stem cell, those referred to as ,facultative, ... is apparently nothing that differentiates these cells from the ... they retain the capacity to become stem cells again. ... an organ that hosts cells that stimulate tissue growth, ... case of a transplant. Knowledge of the underlying ...
(Date:10/29/2014)... October 27, 2014 — Cambridge, MA and Hebei, China ... the complete, high quality sequencing of the Jujube genome. ... Rhamnaceae family, and the Jujube genome is particularly difficult ... other complicating factors. It is the first time that ... sequenced. This study has been recently published in ...
(Date:10/29/2014)... PA, October 29, 2014 – Ghrelin is a hormone ... food intake. Alcohol is commonly viewed as a psychoactive ... also a highly caloric food. , This knowledge, ... the hypothesis that ghrelin has the potential to stimulate ... tested this in humans and found that, as they ...
Breaking Biology News(10 mins):A mechanism that allows a differentiated cell to reactivate as a stem cell revealed 2BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2Ghrelin stimulates an appetite for drinking alcohol 2
... Then it was Jeopardy. Now computers are at ... automate the scientific process itself. An interdisciplinary team ... Research Corporation, Inc., has taken a major step toward ... raw experimental data from a biological system and derive ...
... -- An eight-year study has concluded that increasingly frequent ... have pushed some aquatic desert ecosystems into "catastrophic regime ... The findings, just published in the journal Freshwater ... aquifers for urban water use, and land management may ...
... of Naval Research scientist Dr. Roshdy George S. Barsoum ... for the development of a revolutionary coating material that ... HybridSil Fire/Blast, acts like a force field that surrounds ... ballistic- and fire-resistant. "You can take an existing ...
Cached Biology News:Robot biologist solves complex problem from scratch 2Robot biologist solves complex problem from scratch 3Severe drought, other changes can cause permanent ecosystem disruption 2Severe drought, other changes can cause permanent ecosystem disruption 3Spray-on protective coating wins 'R&D 100' Award 2
(Date:10/30/2014)... Spartan Bioscience announced today that Health Canada ... It detects CYP2C19 genetic mutations in less than 60 ... RX CYP2C19 System is the first near-patient DNA test ... Due to the system’s ease of use, Health Canada ... professionals such as doctors, nurses, pharmacists, and laboratory technicians, ...
(Date:10/30/2014)... Grace Century portfolio project, Provia Laboratories ... of the Board, to the National Stem Cell Ethics ... made by the Ministry of Health on behalf of the ... , More than a year after Bahamian Parliament passed the ... Perry Christie said the government has completed the accompanying regulations ...
(Date:10/30/2014)...  Regado Biosciences, Inc. (Nasdaq: RGDO ), ... and live audio webcast on Thursday, November 6, 2014, ... 2014 financial results. Interested participants and investors ... for domestic callers or (412) 902-4276 for international callers. ... investor relations section of the Regado website at ...
(Date:10/27/2014)... Ryan Carfley , Managing Partner at Personify ... Bryan Hamilton, the publisher of the Triangle Business Journal, and ... Research Triangle region of North Carolina. , Just a few ... include the role of social media in recruitment, recruiting ... the unique role that Millennials play in the workplace today. ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 2Grace Century’s Stem Cell Biobank Project Announces Chairman’s Appointment to National Stem Cell Ethics Committee of The Bahamas 3Regado Biosciences to Provide Third Quarter 2014 Financial Results 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 2Personify's Ryan Carfley Talks Recruiting with Triangle Business Journal, RPG Solutions 3
... FRANCISCO, Aug. 30 BioSpace, the leading ... along with BayBio unveiled this,morning the 11th ... The,campaign features both a regional promotional Hotbed ... conjunction with the economic and,workforce development initiatives ...
... ICx Technologies, a developer of,advanced technology solutions for ... detection business unit, based in Albuquerque, has been,awarded ... of Homeland Security,(DHS) to continue development of a ... granted the award to commence Phase II activities ...
... PRINCETON, N.J., Aug. 30 Medarex, Inc.,(Nasdaq: MEDX ... at the,Thomas Weisel Partners Healthcare Conference at 11:30 AM ... being held at the Four,Seasons Hotel in Boston, Massachusetts. ... for replay through the Webcast page in,the Investor Relations ...
Cached Biology Technology:BioSpace and BayBio Launch 11th Edition of Biotech Bay(TM) Hotbed Map Campaign 2ICx Awarded $1.5 M Contract by Department of Homeland Security for Development of Next Generation Bio Aerosol Systems 2Medarex to Present at Thomas Weisel Partners Healthcare Conference 2007 2
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
MAb to HLA, Class II-DR+DP Dry Ice: No Preservative: NaN3 Availability When Not in Inventory: 14-21 Business Days...
Cell Culture Flask, 25 cm, tissue-culture treated polystyrene...
... Disposable. Virgin, optically clear polystyrene with ... alphanumeric coordinates for cell counting. 100% ... is a new product number, created ... If showing no availability yet, please ...
Biology Products: