Navigation Links
New scientific method unmasks chronic infections
Date:8/8/2012

Chronic infections are a large and growing problem throughout the developed world, and intensive research is being conducted in ways to combat the recalcitrant bacteria. When bacteria aggregate into so-called biofilm, they become resistant to antibiotics. Until now scientists have only been able to speculate about what happens when bacteria overpower the immune system during a chronic infection.

In close collaboration between various specialist fields, Danish scientists have now developed a method that gives a precise picture of how the immune system works. Using 5 mm silicone tubes, scientists created a model system that allows them to look closely at how the immune system and bacteria interact in isolation:

"Although we have always suspected that to cause a chronic infection, bacteria knock out the immune system's white blood cells, the new method allows us to see precisely what happens. Instead of looking down on the bacterial surface, we can examine a section to see the interaction directly and follow how the bacteria react to white blood cells and to antibiotics. That enables us to understand the basic processes behind chronic infections," explains Associate Professor Thomas Bjarnsholt, University of Copenhagen.

PhD student Maria Alhede adds: "The new method allows us to investigate which compounds the bacteria are secreting while overpowering the white blood cells. Conversely, we can also see what happens when the immune system works. The white blood cells make DNA traps that capture the bacteria, but that used to be only a guess," relates Maria Alhede, Department for International Health, Immunology and Microbiology.

Scientists follow the effect of drugs in the organism

The Core Facility for Integrated Microscopy at the Department of Biomedical Sciences has some of Europe's most sophisticated microscopes for conducting health research. By combining light microscopy and electron microscopy, scientists
'/>"/>

Contact: Associate Professor Ph.D. Thomas Bjarnsholt
tbjarnsholt@sund.ku.dk
45-20-65-98-88
University of Copenhagen
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tale of 2 scientific fields -- ecology and phylogenetics -- offers new views of Earths biodiversity
2. Inaugural cross-disciplinary Public Participation in Scientific Research conference
3. FirstMark Scientific Board of Advisors Meet to Discuss New Clinical Studies for PREvent
4. New model in scientific publishing: GigaScience combines article and data publication
5. WALTHAM® demonstrates commitment to scientific dialogue and exchange at international human animal interaction conference
6. CRN assesses current state of scientific research for nutritional supplements
7. Scientific meeting at Virginia Tech will make more than $2 million economic impact
8. NTU researchers study little mighty creature for scientific breakthrough
9. FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisory Board
10. FirstMark Welcomes Renowned Cardiologist and Researcher Dr. Prediman K. Shah to Scientific Advisor Board
11. Womens scientific achievements often overlooked and undervalued
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/24/2014)... This news release is available in German . ... that there are 300 million asthma sufferers worldwide, a ... up to 30% of the global population contending with ... inflammatory diseases can also affect other organs and parts ... occur in the intestine (in the form of inflammatory ...
(Date:7/24/2014)... news release is available in German . ... welcomed in Norway and they are a common sight on ... that electric cars topped the list of new vehicle registrations ... the situation in Germany, where electric vehicles claim only a ... on the roads in Germany, only a mere 8000 are ...
(Date:7/24/2014)... in German . ... respond to threats to health, and to provide life-long ... the mechanism underlying immunologic memory, however, has remained elusive. ... support the hypothesis that the persistence of immune memory ... potential. Until now, there was no conclusive evidence, largely ...
Breaking Biology News(10 mins):New drugs to combat asthma and the like 2New drugs to combat asthma and the like 3Nano-supercapacitors for electric cars 2Nano-supercapacitors for electric cars 3Experiments prove 'stemness' of individual immune memory cells 2Experiments prove 'stemness' of individual immune memory cells 3
... 2011 With millions of people warding off winter,s ... raising red flags about the potential health effects of ... in the American Chemical Society,s (ACS,) journal, Chemical ... inhaled into the lungs from wood smoke may have ...
... Darwin, the "tree of life" has been the preeminent metaphor ... changing of individual species. The discovery that a large ... species of fungus to another, however, significantly strengthens the argument ... more appropriate. "The fungi are telling us something important ...
... reports that family mealtimes that contain three ingredients in the ... who have chronic asthma. "Family mealtimes, when they,re done ... reduced risk of substance abuse, eating disorders, and obesity. In ... we can see minute by minute which factors deliver these ...
Cached Biology News:Discovery of jumping gene cluster tangles tree of life 2Discovery of jumping gene cluster tangles tree of life 3Recipe for family mealtimes calls for 3 ingredients in the right amounts 2
(Date:7/24/2014)... 2014 WIRB-Copernicus Group ® ("WCG")™, ... review services for clinical research, announced today that ... of Richmond, VA -based Alliance ... biosecurity consulting firm in the United ... division – WCG Biosafety™ – will be able ...
(Date:7/24/2014)... Canada (PRWEB) July 24, 2014 The ... Optimizing Dose Escalation in First in Human Studies” will ... make better go/no-go decisions. , With increasing R&D costs ... pharmaceutical companies need to maximize the knowledge collected in ... decisions and improve success in late stage development. , ...
(Date:7/24/2014)... 24, 2014  Spherix Incorporated (SPEX) -- an intellectual ... of intellectual property, today announced that the Company will ... 30, 2014 on Monday, August 18, 2014 for shareholders. ... ET on Monday, August 18, 2014 to discuss the ... company,s CEO, Anthony Hayes . Following ...
(Date:7/24/2014)... 24, 2014 As part of the ... in the MENA region during 2014 with potential global ... provider agreement with DZS to manage our clinical trials ... Global VP of R&D and President of SBI pharmaceuticals ... operational practices with a focus on utilizing eClinical software ...
Breaking Biology Technology:WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 2WIRB-Copernicus Group Announces Acquisition of Alliance Biosciences; Executives Join WCG Biosafety Division 3Best Practices for Optimizing Dose Escalation in First in Human Studies, New Webinar August 6th Hosted by Xtalks 2Spherix Schedules Shareholder Update Call 2SBI Pharmaceuticals Co. Ltd. Enters into Preferred Provider Agreement with DZS Clinical Services 2
... Inc.,(Nasdaq: ONTY ) (TSX: ONY) (the "Company") ... in a Phase 1b clinical trial of PX-12 ... proprietary small molecule,inhibitor of thioredoxin, a protein that ... survival and drug resistance of,many cancers., The ...
... and present a poster on proprietary siRNA ... targeting and ... Pharmaceuticals, Inc., a,development-stage pharmaceutical company discovering and developing novel,RNA ... Cambridge Healthcare Institute,s 9th Annual Beyond,Genome Conference on June ...
... Calif., June 10 DURECT Corporation,(Nasdaq: DRRX ... (NDA) for,Remoxy(TM) (ORADUR(TM)-based oxycodone) has been submitted to ... investigational drug, is a long,acting oral formulation of ... on DURECT,s ORADUR technology, Remoxy is designed to ...
Cached Biology Technology:Oncothyreon initiates Phase 1b trial of PX-12 in patients with advanced metastatic cancer 2Oncothyreon initiates Phase 1b trial of PX-12 in patients with advanced metastatic cancer 3Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference 2Quark Pharmaceuticals to Participate in 9th Annual Beyond Genome Conference 3New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 2New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 3New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 4New Drug Application Submitted for Remoxy(TM) (ORADUR(TM)-Based Oxycodone) 5
Human plasmacytoid dendritic cells, BDCA-4+, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Umbilical cord blood basophils, For immunohistochemistry (IHC)...
Human peripheral blood CD8+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood PBMC and T Cells...
Umbilical cord blood CD4+ T cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood MNCs and T Cells...
Biology Products: